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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Zymomonas mobilis subsp. pomaceae (strain ATCC 29192 / JCM 10191 / NBRC 13757 / NCIMB 11200 / NRRL B-4491)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:Zymop_0633
OrganismiZymomonas mobilis subsp. pomaceae (strain ATCC 29192 / JCM 10191 / NBRC 13757 / NCIMB 11200 / NRRL B-4491)
Taxonomic identifieri579138 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaSphingomonadalesSphingomonadaceaeZymomonas
Proteomesi
  • UP000000491 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543961 – 211N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST211

Interactioni

Protein-protein interaction databases

STRINGi579138.Zymop_0633.

Structurei

3D structure databases

ProteinModelPortaliQ9S3U4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB. Bacteria.
COG0135. LUCA.
KOiK01817.
OMAiFVNASRC.
OrthoDBiPOG091H01PA.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S3U4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVRTKICGI STPETLLAAV KNGASHIGFV FFEKSPRAVQ PEMASMLINR
60 70 80 90 100
IPDHIDKIGV LVDPDDNLLE RVVHAGLTGF QLHGHETPER VAFIRRTFPK
110 120 130 140 150
VKIWKALPIT RSQDLDQTLH YRGLVDRVLY DARTDGALPG GMGKRFDWRL
160 170 180 190 200
LKDYNHPMAW ALSGGLDADN IAQAVAITGA ELVDVSSGVE TAPGIKDMDK
210
IAQFLQAVRL L
Length:211
Mass (Da):23,262
Last modified:December 14, 2011 - v2
Checksum:i385307A59D1F856E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10I → L in AAD51337 (Ref. 1) Curated1
Sequence conflicti13 – 26PETLL…NGASH → EETVETAVRYGADY in AAD51337 (Ref. 1) CuratedAdd BLAST14
Sequence conflicti38 – 45AVQPEMAS → SVTPEKAA in AAD51337 (Ref. 1) Curated8
Sequence conflicti49 – 50NR → RQ in AAD51337 (Ref. 1) Curated2
Sequence conflicti55 – 56ID → VQ in AAD51337 (Ref. 1) Curated2
Sequence conflicti61L → F in AAD51337 (Ref. 1) Curated1
Sequence conflicti66D → N in AAD51337 (Ref. 1) Curated1
Sequence conflicti72 – 75VVHA → ALAS in AAD51337 (Ref. 1) Curated4
Sequence conflicti88P → A in AAD51337 (Ref. 1) Curated1
Sequence conflicti91 – 96VAFIRR → IASIRE in AAD51337 (Ref. 1) Curated6
Sequence conflicti108 – 111PITR → SIAN in AAD51337 (Ref. 1) Curated4
Sequence conflicti116 – 119DQTL → AQAP in AAD51337 (Ref. 1) Curated4
Sequence conflicti125V → A in AAD51337 (Ref. 1) Curated1
Sequence conflicti128V → L in AAD51337 (Ref. 1) Curated1
Sequence conflicti137A → V in AAD51337 (Ref. 1) Curated1
Sequence conflicti144K → R in AAD51337 (Ref. 1) Curated1
Sequence conflicti153 – 159DYNHPMA → EYKHPLP in AAD51337 (Ref. 1) Curated7
Sequence conflicti169D → H in AAD51337 (Ref. 1) Curated1
Sequence conflicti185V → I in AAD51337 (Ref. 1) Curated1
Sequence conflicti192A → S in AAD51337 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173835 Genomic DNA. Translation: AAD51337.1.
CP002865 Genomic DNA. Translation: AEI37535.1.
RefSeqiWP_013933934.1. NC_015709.1.

Genome annotation databases

EnsemblBacteriaiAEI37535; AEI37535; Zymop_0633.
KEGGizmp:Zymop_0633.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF173835 Genomic DNA. Translation: AAD51337.1.
CP002865 Genomic DNA. Translation: AEI37535.1.
RefSeqiWP_013933934.1. NC_015709.1.

3D structure databases

ProteinModelPortaliQ9S3U4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi579138.Zymop_0633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAEI37535; AEI37535; Zymop_0633.
KEGGizmp:Zymop_0633.

Phylogenomic databases

eggNOGiENOG4108ZGB. Bacteria.
COG0135. LUCA.
KOiK01817.
OMAiFVNASRC.
OrthoDBiPOG091H01PA.

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTRPF_ZYMMT
AccessioniPrimary (citable) accession number: Q9S3U4
Secondary accession number(s): F8ERS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: December 14, 2011
Last modified: November 2, 2016
This is version 68 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.