Q9S3M0 (CDD_BACPY) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytidine deaminase
Short name=CDA
EC=3.5.4.5

Alternative name(s):
Cytidine aminohydrolase

Gene names

Name:

cdd

Organism

Bacillus psychrophilus (Sporosarcina psychrophila)

Taxonomic identifier

1476 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Planococcaceae › Sporosarcina

Protein attributes

Sequence length	136 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity.
Catalytic activity	Cytidine + H2O = uridine + NH3.
Cofactor	Zinc By similarity.
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 136	136	Cytidine deaminase		PRO_0000171677
Regions
	Region	42 – 44	3	Substrate binding By similarity
Sites
	Active site	55	1	Proton donor By similarity
	Metal binding	53	1	Zinc; catalytic By similarity
	Metal binding	86	1	Zinc; catalytic By similarity
	Metal binding	89	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S3M0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 323DDC0450EC3E62	FASTA	136	14,600
	10 20 30 40 50 60 MDVEKLIAES KKAREQAYVP YSKFPVGAAL LAEDGTIYHG CNIENSAYSM TNCAERTAFF 70 80 90 100 110 120 KAVSDGVRSF KALAVVADTE GPVSPCGACR QVIAEFCNGS MPVYLTNLKG DIEETTVAKL 130 LPGAFSKEDL SYAAEQ

References

[1]	"Cytidine deaminase from two extremophilic bacteria: cloning, expression and comparison of their structural stability." Cambi A., Vincenzetti S., De Sanctis G., Neuhard J., Natalini P., Vita A. Protein Eng. 14:807-813(2001) [PubMed: 11739901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ237978 Genomic DNA. Translation: CAB51906.1.
3D structure databases
ProteinModelPortal	Q9S3M0.
SMR	Q9S3M0. Positions 1-130.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Enzyme and pathway databases
BRENDA	3.5.4.5. 685.
Family and domain databases
InterPro	IPR002125. CMP_dCMP_Zn-bd. IPR006262. Cyt_deam_tetra. IPR016193. Cytidine_deaminase-like. [Graphical view]
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. [Graphical view]
SUPFAM	SSF53927. Cytidine_deaminase-like. 1 hit.
TIGRFAMs	TIGR01354. Cyt_deam_tetra. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CDD_BACPY

Accession

Primary (citable) accession number: Q9S3M0

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 13, 2002
Last sequence update:	May 1, 2000
Last modified:	May 31, 2011
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program