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Q9S3M0

- CDD_SPOPS

UniProt

Q9S3M0 - CDD_SPOPS

Protein

Cytidine deaminase

Gene

cdd

Organism
Sporosarcina psychrophila (Bacillus psychrophilus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.By similarity

    Catalytic activityi

    Cytidine + H2O = uridine + NH3.
    2'deoxycytidine + H2O = 2'-deoxyuridine + NH3.

    Cofactori

    Zinc.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Zinc; catalyticBy similarity
    Active sitei55 – 551Proton donorBy similarity
    Metal bindingi86 – 861Zinc; catalyticBy similarity
    Metal bindingi89 – 891Zinc; catalyticBy similarity

    GO - Molecular functioni

    1. cytidine deaminase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BRENDAi3.5.4.5. 685.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytidine deaminase (EC:3.5.4.5)
    Short name:
    CDA
    Alternative name(s):
    Cytidine aminohydrolase
    Gene namesi
    Name:cdd
    OrganismiSporosarcina psychrophila (Bacillus psychrophilus)
    Taxonomic identifieri1476 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPlanococcaceaeSporosarcina

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 136136Cytidine deaminasePRO_0000171677Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ9S3M0.
    SMRiQ9S3M0. Positions 1-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 9795CMP/dCMP deaminase zinc-bindingAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni42 – 443Substrate bindingBy similarity

    Sequence similaritiesi

    Family and domain databases

    InterProiIPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view]
    PfamiPF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR01354. cyt_deam_tetra. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9S3M0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVEKLIAES KKAREQAYVP YSKFPVGAAL LAEDGTIYHG CNIENSAYSM    50
    TNCAERTAFF KAVSDGVRSF KALAVVADTE GPVSPCGACR QVIAEFCNGS 100
    MPVYLTNLKG DIEETTVAKL LPGAFSKEDL SYAAEQ 136
    Length:136
    Mass (Da):14,600
    Last modified:May 1, 2000 - v1
    Checksum:i323DDC0450EC3E62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ237978 Genomic DNA. Translation: CAB51906.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ237978 Genomic DNA. Translation: CAB51906.1 .

    3D structure databases

    ProteinModelPortali Q9S3M0.
    SMRi Q9S3M0. Positions 1-130.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    BRENDAi 3.5.4.5. 685.

    Family and domain databases

    InterProi IPR002125. CMP_dCMP_Zn-bd.
    IPR006262. Cyt_deam_tetra.
    IPR016193. Cytidine_deaminase-like.
    [Graphical view ]
    Pfami PF00383. dCMP_cyt_deam_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR01354. cyt_deam_tetra. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cytidine deaminase from two extremophilic bacteria: cloning, expression and comparison of their structural stability."
      Cambi A., Vincenzetti S., De Sanctis G., Neuhard J., Natalini P., Vita A.
      Protein Eng. 14:807-813(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiCDD_SPOPS
    AccessioniPrimary (citable) accession number: Q9S3M0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 13, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3