SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9S375

- PSA_MYCLE

UniProt

Q9S375 - PSA_MYCLE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Proteasome subunit alpha
Gene
prcA, ML1323, B2126_C3_260
Organism
Mycobacterium leprae (strain TN)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation By similarity.UniRule annotation

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.UniRule annotation

Enzyme regulationi

The formation of the proteasomal ATPase ARC-20S proteasome complex, likely via the docking of the C-termini of ARC into the intersubunit pockets in the alpha-rings, may trigger opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity By similarity.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. threonine-type endopeptidase activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. proteolysis involved in cellular protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Threonine protease

Enzyme and pathway databases

UniPathwayiUPA00997.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome subunit alpha (EC:3.4.25.1)
Alternative name(s):
20S proteasome alpha subunit
Proteasome core protein PrcA
Gene namesi
Name:prcA
Ordered Locus Names:ML1323
ORF Names:B2126_C3_260
OrganismiMycobacterium leprae (strain TN)
Taxonomic identifieri272631 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacterium
ProteomesiUP000000806: Chromosome

Organism-specific databases

LepromaiML1323.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. proteasome core complex, alpha-subunit complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 265265Proteasome subunit alphaUniRule annotation
PRO_0000397151Add
BLAST

Interactioni

Subunit structurei

The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped by the proteasome-associated ATPase, ARC By similarity.

Protein-protein interaction databases

STRINGi272631.ML1323.

Structurei

3D structure databases

ProteinModelPortaliQ9S375.
SMRiQ9S375. Positions 8-237.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.

Phylogenomic databases

eggNOGiCOG0638.
HOGENOMiHOG000245319.
KOiK03432.
OMAiGRYNEFE.
OrthoDBiEOG6NKQZG.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00289_B. Proteasome_A_B.
InterProiIPR029055. Ntn_hydrolases_N.
IPR022296. Proteasome_asu_bac.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
PfamiPF00227. Proteasome. 1 hit.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR03691. 20S_bact_alpha. 1 hit.
PROSITEiPS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9S375-1 [UniParc]FASTAAdd to Basket

« Hide

MSFPYFISPE QAMRERSELA RKGIARGRSV VALAYAGGVL FVAENPSRSL    50
QKISELYDRV GFAAAGKFNE FDNLRRGGIQ FADTRGYAYD RRDVTGRQLA 100
NVYAQTLGTI FTEQAKPYEV ELCVAEVAHY GETKPPELYR ITYDGSINDE 150
PHFMVMGGTT ESIANALKES YAENASLTDA LGIAVAALRA GSADAAGSDQ 200
PTLGVASLEV AVLDANRPRR AFRRIIGSGL EALLREKDSK GSKGAQNPKG 250
ARDSKNSKSY GESTD 265
Length:265
Mass (Da):28,677
Last modified:May 1, 2000 - v1
Checksum:iC53A39054284FF9E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 172RS → QR in AAA17205. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00017 Genomic DNA. Translation: AAA17205.1.
AL035310 Genomic DNA. Translation: CAA22934.1.
AL583921 Genomic DNA. Translation: CAC31704.1.
PIRiE87074.
S72865.
RefSeqiNP_301951.1. NC_002677.1.
WP_010908272.1. NC_002677.1.

Genome annotation databases

EnsemblBacteriaiCAC31704; CAC31704; CAC31704.
GeneIDi910449.
KEGGimle:ML1323.
PATRICi18055004. VBIMycLep78757_2440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U00017 Genomic DNA. Translation: AAA17205.1 .
AL035310 Genomic DNA. Translation: CAA22934.1 .
AL583921 Genomic DNA. Translation: CAC31704.1 .
PIRi E87074.
S72865.
RefSeqi NP_301951.1. NC_002677.1.
WP_010908272.1. NC_002677.1.

3D structure databases

ProteinModelPortali Q9S375.
SMRi Q9S375. Positions 8-237.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272631.ML1323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC31704 ; CAC31704 ; CAC31704 .
GeneIDi 910449.
KEGGi mle:ML1323.
PATRICi 18055004. VBIMycLep78757_2440.

Organism-specific databases

Lepromai ML1323.

Phylogenomic databases

eggNOGi COG0638.
HOGENOMi HOG000245319.
KOi K03432.
OMAi GRYNEFE.
OrthoDBi EOG6NKQZG.

Enzyme and pathway databases

UniPathwayi UPA00997 .

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
HAMAPi MF_00289_B. Proteasome_A_B.
InterProi IPR029055. Ntn_hydrolases_N.
IPR022296. Proteasome_asu_bac.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view ]
Pfami PF00227. Proteasome. 1 hit.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR03691. 20S_bact_alpha. 1 hit.
PROSITEi PS51475. PROTEASOME_ALPHA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Smith D.R., Robison K.
    Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TN.

Entry informationi

Entry nameiPSA_MYCLE
AccessioniPrimary (citable) accession number: Q9S375
Secondary accession number(s): Q49792
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 10, 2010
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi