Q9S372 (Q9S372_MYCLE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit alpha RuleBase RU000699
EC=6.2.1.5 RuleBase RU000699

Gene names

Name:	sucD EMBL CAB36666.1
Ordered Locus Names:	ML0156

Organism

Mycobacterium leprae [Complete proteome] [HAMAP] EMBL CAB36666.1

Taxonomic identifier

1769 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium

Protein attributes

Sequence length	300 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. RuleBase RU000699
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity. RuleBase RU000699
Sequence similarities	Belongs to the succinate/malate CoA ligase alpha subunit family. RuleBase RU000677

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle RuleBase RU000677
Ligand	ATP-binding RuleBase RU000699 Nucleotide-binding
Molecular function	Ligase RuleBase RU000677 EMBL CAC29664.1
PTM	Phosphoprotein RuleBase RU000677
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP citrate synthase activity Inferred from electronic annotation. Source: InterPro succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	256	1	Tele-phosphohistidine intermediate By similarity PIRSR PIRSR001553-1

Sequences

	Sequence		Length	Mass (Da)
	Q9S372 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: F2508C58A85B6E53	FASTA	300	30,954
	10 20 30 40 50 60 MAIFLTKDNT VIVQGITGSE AAVHTARMLK AGTQIVGGVN ARKAGTNVTH EDKHGRIITL 70 80 90 100 110 120 PVFGTVAEAI ENTGADVSII FVPPRFAKEA IIEAVEAEIP LLVIITEGIP VQDSVYAWAY 130 140 150 160 170 180 NLNKGTKTRI IGPNCPGIIT PGQSLVGITP ATITGAGPIG LVSKSGTLTY QMMFELSDFG 190 200 210 220 230 240 FSTAIGIGGD PVIGTTHIDA IEAFEQDPDT KIIVMIGEIG GDAEERAADY IKANVSKPVV 250 260 270 280 290 300 GYVAGFTAPE GKTMGHAGAI VSGSSGTAAV KKDALEAAGV KVGKTPSETA VLVREILCTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Use of an ordered cosmid library to deduce the genomic organization of Mycobacterium leprae." Eiglmeier K., Honore N., Woods S.A., Caudron B., Cole S.T. Mol. Microbiol. 7:197-206(1993) [PubMed: 8446027] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Massive gene decay in the leprosy bacillus." Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R., Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E., Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K., Duthoy S. , Feltwell T., Fraser A., Hamlin N., Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S., Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R., Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R., Barrell B.G. Nature 409:1007-1011(2001) [PubMed: 11234002] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: TN.
[3]	James K.D., Parkhill J., Barrell B.G., Rajandream M.A. Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	Harris D., Taylor K. Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL035500 Genomic DNA. Translation: CAB36666.1. AL583917 Genomic DNA. Translation: CAC29664.1.
PIR	T45435.
RefSeq	NP_301242.1. NC_002677.1.
3D structure databases
HSSP	HSSP built from PDB template 1JKJ based on UniProtKB P07459.
ProteinModelPortal	Q9S372.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000029260; EBMYCP00000028866; EBMYCG00000029255.
GeneID	908514.
GenomeReviews	Gene locus ML0156 in contig AL450380_GR.
KEGG	mle:ML0156.
NMPDR	fig|272631.1.peg.114.
PATRIC	18050575. VBIMycLep78757_0241.
Organism-specific databases
Leproma	ML0156.
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016700.
HOGENOM	HBG615372.
OMA	APPGRTM.
ProtClustDB	PRK05678.
Family and domain databases
InterPro	IPR017440. Cit_synth/succinyl-CoA_lig_AS. IPR003781. CoA-bd. IPR005810. CoA_lig_alpha. IPR005811. CoA_ligase. IPR016040. NAD(P)-bd_dom. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KO	K01902.
Pfam	PF02629. CoA_binding. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001553. SucCS_alpha. 1 hit.
PRINTS	PR01798. SCOASYNTHASE.
SMART	SM00881. CoA_binding. 1 hit. [Graphical view]
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01019. SucCoAalpha. 1 hit.
PROSITE	PS01216. SUCCINYL_COA_LIG_1. 1 hit. PS00399. SUCCINYL_COA_LIG_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9S372_MYCLE

Accession

Primary (citable) accession number: Q9S372

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	December 14, 2011
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)