Reviewed, UniProtKB/Swiss-Prot Q9S358 (TRPE_NEIMF)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	NMC1013

Organism

Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / FAM18) [Complete proteome] [HAMAP]

Taxonomic identifier

272831 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Neisseriales › Neisseriaceae › Neisseria

Protein attributes

Sequence length	491 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 491	491	Anthranilate synthase component 1		PRO_0000154105

Sequences

	Sequence		Length	Mass (Da)
	Q9S358-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: FC7053315D19EA7B	FASTA	491	54,719
	10 20 30 40 50 60 MISKQEYQAQ AAQGYNRIPL VQELLADLDT PLSLYLKLAN RPYTYLLESV VGGERFGRYS 70 80 90 100 110 120 FIGLPCSHYL KASGKHVDVY QNGEIVEQHD GNPLPFIEAF HNRFKTPEIP SLPRFTGGLV 130 140 150 160 170 180 GYFGYETIYN FEHFAHRLKN TTKADPLGTP DILLMLSQEL AVVDNLSGKI YLIVYADPSQ 190 200 210 220 230 240 PDGYERARER LEDIRTQLRQ SCAIPLSLGS KHTEAVSEFG EEPFKACVNK IKDYIFAGDC 250 260 270 280 290 300 MQVVPSQRMS MEFTDSSLAL YRALRTLNPS PYLFYYDFGD FHIVGSSPEI LVRRERDDVI 310 320 330 340 350 360 VRPIAGTRLR GKTPAEDLAN EQDLLSDAKE IAEHVMLIDL GRNDVGRISK TGEVKVTDKM 370 380 390 400 410 420 VIEKYSHVMH IVSNVEGRLK DGMTNMDILA ATFPAGTLSG APKVRAMEII EEVEPSKRGI 430 440 450 460 470 480 YGGAVGVWGF NNDMDLAIAI RTAVVKNNTL YVQSGAGVVA DSDPASEWQE TQNKARAVIH 490 AAQMVQEGLD K

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The opcA and (psi)opcB regions in Neisseria: genes, pseudogenes, deletions, insertion elements and DNA islands." Zhu P., Morelli G., Achtman M. Mol. Microbiol. 33:635-650(1999) [PubMed: 10417653] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Meningococcal genetic variation mechanisms viewed through comparative analysis of serogroup C strain FAM18." Bentley S.D., Vernikos G.S., Snyder L.A.S., Churcher C., Arrowsmith C., Chillingworth T., Cronin A., Davis P.H., Holroyd N.E., Jagels K., Maddison M., Moule S., Rabbinowitsch E., Sharp S., Unwin L., Whitehead S., Quail M.A., Achtman M. , Barrell B.G., Saunders N.J., Parkhill J. PLoS Genet. 3:230-240(2007) [PubMed: 17305430] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	AJ242842 Genomic DNA. Translation: CAB44980.1. AM421808 Genomic DNA. Translation: CAM10278.1.
RefSeq	YP_975067.1.
3D structure databases
HSSP	HSSP built from PDB template 1K0E based on UniProtKB P05041.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9S358.
Genome annotation databases
GeneID	4675564.
GenomeReviews	Gene locus NMC1013 in contig AM421808_GR.
KEGG	nmc:NMC1013.
NMPDR	fig|487.2.peg.2042.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VKVTDKM.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR005256. Anth_synthI. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
ProDom	PD000779. Anth_synth_chor. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00564. trpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_NEIMF

Accession

Primary (citable) accession number: Q9S358
Secondary accession number(s): A1KTT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)