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Protein

Thiazole synthase

Gene

thiG

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H2S.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-[sulfur-carrier protein ThiS] = 2-((2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene)ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O.UniRule annotation

Pathwayi: thiamine diphosphate biosynthesis

This protein is involved in the pathway thiamine diphosphate biosynthesis, which is part of Cofactor biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway thiamine diphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei98Schiff-base intermediate with DXPUniRule annotation1
Binding sitei159DXP; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processThiamine biosynthesis
LigandSchiff base

Enzyme and pathway databases

UniPathwayiUPA00060

Names & Taxonomyi

Protein namesi
Recommended name:
Thiazole synthaseUniRule annotation (EC:2.8.1.10UniRule annotation)
Gene namesi
Name:thiGUniRule annotation
Ordered Locus Names:SCO2109
ORF Names:SC6E10.03
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001628631 – 264Thiazole synthaseAdd BLAST264

Interactioni

Subunit structurei

Homotetramer. Forms heterodimers with either ThiH or ThiS.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO2109

Structurei

3D structure databases

ProteinModelPortaliQ9S2N4
SMRiQ9S2N4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni185 – 186DXP bindingUniRule annotation2
Regioni207 – 208DXP bindingUniRule annotation2

Sequence similaritiesi

Belongs to the ThiG family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CA8 Bacteria
COG2022 LUCA
HOGENOMiHOG000248049
InParanoidiQ9S2N4
KOiK03149
OMAiAQYPSPA
OrthoDBiPOG091H01K9
PhylomeDBiQ9S2N4

Family and domain databases

CDDicd04728 ThiG, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00443 ThiG, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033983 Thiazole_synthase_ThiG
IPR008867 ThiG
PANTHERiPTHR34266 PTHR34266, 1 hit
PfamiView protein in Pfam
PF05690 ThiG, 1 hit

Sequencei

Sequence statusi: Complete.

Q9S2N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADDPFVLGG TTYASRLIMG TGGAPSLDVL ERALVASGTE LTTVAMRRVN
60 70 80 90 100
ASVHGSVLSV LERLGIRVLP NTAGCFTAGE AVLTARLARE ALGTDLVKLE
110 120 130 140 150
VIADERTLLP DPVELLDAAE TLVDDGFTVL PYTNDDPVLA RKLEDAGCAA
160 170 180 190 200
IMPLGSPIGS GLGIRNPHNF QLIVEHARVP VILDAGAGTA SDVALAMELG
210 220 230 240 250
CAGVMLASAV TRAQEPVLMA AAMRAGVEAG RLARRAGRIP RRHFAEASSP
260
AEGLAVLDPE RPAF
Length:264
Mass (Da):27,392
Last modified:May 1, 2000 - v1
Checksum:iAF5D5AD9FC6BAB23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939111 Genomic DNA Translation: CAB51957.1
PIRiT35490
RefSeqiNP_626366.1, NC_003888.3
WP_003976707.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB51957; CAB51957; CAB51957
GeneIDi1097543
KEGGisco:SCO2109
PATRICifig|100226.15.peg.2143

Similar proteinsi

Entry informationi

Entry nameiTHIG_STRCO
AccessioniPrimary (citable) accession number: Q9S2N4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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