Q9S2L4 (PIP_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable proline iminopeptidase
Short name=PIP
EC=3.4.11.5

Alternative name(s):
Prolyl aminopeptidase
Short name=PAP

Gene names

Ordered Locus Names:	SCO1989
ORF Names:	SC7H2.03c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Specifically catalyzes the removal of N-terminal proline residues from peptides By similarity.
Catalytic activity	Release of N-terminal proline from a peptide.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase S33 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Aminopeptidase Hydrolase Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 323	323	Probable proline iminopeptidase		PRO_0000080846
Sites
	Active site	114	1	Nucleophile By similarity
	Active site	271	1	By similarity
	Active site	299	1	Proton donor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S2L4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 7BEF00133B353EEB	FASTA	323	35,040
	10 20 30 40 50 60 MSLYPEIEPY DHGMLDVGDG NHVYWETCGN PHGKPAVVLH GGPGSRASPG LRRYFDPAAY 70 80 90 100 110 120 RIVLLDQRGA GRSLPRASAP DTDMSVNTTA HLMADLERLR VHLGIERWLV WGVSWGSVLG 130 140 150 160 170 180 LRYAQTHPGV VTELVLTGVA TGSNAEVALL TRGLGNIFPE AHERFLAELP PDARDGNLPA 190 200 210 220 230 240 AYNRLLESPD PAVRERAARA WTDWETATIP APPGSVARYQ DPDFRMGFAR TVTHYWGNDH 250 260 270 280 290 300 FLGDGNDEGV VIRDAHLLKG IPGTLVQGSL DFGNLLGIVW RLHHAWPDSD LVIVDEAGHD 310 320 AGTTGDEALL AATDKYARGG TAE

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939111 Genomic DNA. Translation: CAB52045.1.
PIR	T35734.
RefSeq	NP_626250.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9S2L4.
ModBase	Search...
Protein family/group databases
MEROPS	S33.001.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1097423.
GenomeReviews	Gene locus SCO1989 in contig AL645882_GR.
KEGG	sco:SCO1989.
NMPDR	fig|100226.1.peg.1955.
PATRIC	23733612. VBIStrCoe124346_2016.
Phylogenomic databases
HOGENOM	HBG677789.
OMA	RLVTHYW.
ProtClustDB	CLSK635488.
Family and domain databases
InterPro	IPR005944. Pept_S33. IPR002410. Peptidase_S33. [Graphical view]
KO	K01259.
PANTHER	PTHR10992:SF12. PTHR10992:SF12. 1 hit.
PIRSF	PIRSF006431. Pept_S33. 1 hit.
PRINTS	PR00793. PROAMNOPTASE.
TIGRFAMs	TIGR01249. Pro_imino_pep_1. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PIP_STRCO

Accession

Primary (citable) accession number: Q9S2L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program