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Protein

Non-canonical purine NTP pyrophosphatase

Gene

SCO2902

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi72 – 721Magnesium or manganeseUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation
Binding sitei178 – 1781SubstrateUniRule annotation
Binding sitei184 – 1841SubstrateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
Alternative name(s):
Non-standard purine NTP pyrophosphataseUniRule annotation
Nucleoside-triphosphate diphosphataseUniRule annotation
Nucleoside-triphosphate pyrophosphataseUniRule annotation
Short name:
NTPaseUniRule annotation
Gene namesi
Ordered Locus Names:SCO2902
ORF Names:SCE19A.02c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Non-canonical purine NTP pyrophosphatasePRO_0000178238Add
BLAST

Proteomic databases

PRIDEiQ9S2H9.

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO2902.

Structurei

3D structure databases

ProteinModelPortaliQ9S2H9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni8 – 136Substrate bindingUniRule annotation
Regioni72 – 732Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the HAM1 NTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108V82. Bacteria.
COG0127. LUCA.
HOGENOMiHOG000293319.
InParanoidiQ9S2H9.
KOiK02428.
OMAiTHNPGKV.
OrthoDBiEOG6CZQQP.
PhylomeDBiQ9S2H9.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S2H9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRLILATRN AGKITELRAI LADAGLPHDL VGADAYPHIP DVKETGVTFA
60 70 80 90 100
ENALLKAHAL AEATGLPAVA DDSGLCVDVL NGAPGIFSAR WAGRHGDDQA
110 120 130 140 150
NLDLLLAQIA DIADEHRGAH FACAAALALP DGTERVVEGQ LKGTLRHAPA
160 170 180 190 200
GTGGFGYDPI LQPEGETRTC AELTAEEKNA ISHRGKAFRA LVPVVRELLG
Length:200
Mass (Da):20,890
Last modified:May 1, 2000 - v1
Checksum:iAB1F41B4C448620C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939114 Genomic DNA. Translation: CAB50983.1.
PIRiT36125.
RefSeqiNP_627128.1. NC_003888.3.
WP_011028655.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB50983; CAB50983; CAB50983.
GeneIDi1098335.
KEGGisco:SCO2902.
PATRICi23735532. VBIStrCoe124346_2961.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939114 Genomic DNA. Translation: CAB50983.1.
PIRiT36125.
RefSeqiNP_627128.1. NC_003888.3.
WP_011028655.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9S2H9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO2902.

Proteomic databases

PRIDEiQ9S2H9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50983; CAB50983; CAB50983.
GeneIDi1098335.
KEGGisco:SCO2902.
PATRICi23735532. VBIStrCoe124346_2961.

Phylogenomic databases

eggNOGiENOG4108V82. Bacteria.
COG0127. LUCA.
HOGENOMiHOG000293319.
InParanoidiQ9S2H9.
KOiK02428.
OMAiTHNPGKV.
OrthoDBiEOG6CZQQP.
PhylomeDBiQ9S2H9.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00042. TIGR00042. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiNTPA_STRCO
AccessioniPrimary (citable) accession number: Q9S2H9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.