Q9S2F4 (HPPD_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
4-hydroxyphenylpyruvate dioxygenase
Short name=4HPPD
Short name=HPD
Short name=HPPDase
EC=1.13.11.27

Gene names

Name:	hpd
Ordered Locus Names:	SCO2927
ORF Names:	SCE19A.27c

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	381 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-hydroxyphenylpyruvate + O2 = homogentisate + CO2.
Cofactor	Binds 1 iron ion per subunit By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the 4HPPD family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	4-hydroxyphenylpyruvate dioxygenase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 381	381	4-hydroxyphenylpyruvate dioxygenase		PRO_0000088410
Sites
	Metal binding	187	1	Iron By similarity
	Metal binding	270	1	Iron By similarity
	Metal binding	349	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S2F4 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 326B241FF9BAC49E	FASTA	381	41,876
	10 20 30 40 50 60 MTQTTHHTPD TARQADPFPV KGMDAVVFAV GNAKQAAHYY STAFGMKLVA YSGPENGSRE 70 80 90 100 110 120 TASYVLESGS ARFVFTSVIK PSTDWGTFLA QHVAEHGDGV VDLAIEVPDA RAAHAYAVEH 130 140 150 160 170 180 GARSLAEPHE VKDEHGTVVL AAIATYGETR HTLVERTGYD GPYLPGYVAA KPMVAPPAQR 190 200 210 220 230 240 VFQAVDHCVG NVELGRMNEW VGFYNKVMGF TNMKEFVGDD IATEYSALMS KVVADGTLKV 250 260 270 280 290 300 KFPINEPAIA KKKSQIDEYL EFYGGAGVQH IALNTNDIVA TVRAMRAAGV EFLDTPDSYY 310 320 330 340 350 360 DTLGEWAGET RVPVDVLREL KILVDRDEDG YLLQIFTKPV QDRPTVFFEM IERHGSMGFG 370 380 KGNFKALFEA IEREQEKRGN L

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939114 Genomic DNA. Translation: CAB51008.1.
PIR	T36150.
RefSeq	NP_627153.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9S2F4.
SMR	Q9S2F4. Positions 16-377.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1098360.
GenomeReviews	Gene locus SCO2927 in contig AL645882_GR.
KEGG	sco:SCO2927.
NMPDR	fig|100226.1.peg.2889.
PATRIC	23735580. VBIStrCoe124346_2985.
Phylogenomic databases
HOGENOM	HBG680392.
OMA	HCVGNVE.
PhylomeDB	Q9S2F4.
ProtClustDB	CLSK902447.
Family and domain databases
InterPro	IPR005956. 4OHPhenylPyrv_dOase. IPR004360. Glyas_Fos-R_dOase. [Graphical view]
KO	K00457.
PANTHER	PTHR11959. HPP_dOase. 1 hit.
Pfam	PF00903. Glyoxalase. 1 hit. [Graphical view]
PIRSF	PIRSF009283. HPP_dOase. 1 hit.
TIGRFAMs	TIGR01263. 4HPPD. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HPPD_STRCO

Accession

Primary (citable) accession number: Q9S2F4

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 68 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program