Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9S2C0 (PKSC_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase PksC

EC=2.7.11.1
Gene names
Name:pksC
Ordered Locus Names:SCO3821
ORF Names:SCGD3.22
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Protein attributes

Sequence length556 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 PASTA domain.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 556556Serine/threonine-protein kinase PksC
PRO_0000171236

Regions

Domain20 – 287268Protein kinase
Domain482 – 55069PASTA
Nucleotide binding26 – 349ATP By similarity
Compositional bias318 – 39073Pro-rich

Sites

Active site1511Proton acceptor By similarity
Binding site491ATP By similarity

Experimental info

Sequence conflict801I → M in AAC64406. Ref.1
Sequence conflict991I → L in AAC64406. Ref.1
Sequence conflict1101G → C in AAC64406. Ref.1
Sequence conflict1471L → V in AAC64406. Ref.1
Sequence conflict3391P → L in AAC64406. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9S2C0 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D4A22A2F39F4ADC1

FASTA55658,262
        10         20         30         40         50         60 
MSQDGGQGRY AGRALAGGRY QLRDLLGEGG MASVHLAYDS VLDRQVAIKT LHTELGREQA 

        70         80         90        100        110        120 
FRERFRREAQ AVAKLTHTNI VSVFDTGEDD LDGMTTPYIV MEYVEGRPLG SVLDEDVRQQ 

       130        140        150        160        170        180 
GAMPADKALK ITADVLAALE ISHEMGLVHR DIKPGNVMMT KRGVVKVMDF GIARAMQSGV 

       190        200        210        220        230        240 
TSMTQTGMVV GTPQYLSPEQ ALGRGVDARS DLYSVGIMLF QLVTGRLPFD ADSPLAIAYA 

       250        260        270        280        290        300 
HVQEQPVAPS AVNRALPPAV DALVARALKK NPNERFPSAE AMRDECLRVA ASFQAAPPSI 

       310        320        330        340        350        360 
VPGAQTSSGA GVGSAVFPPV GQGTPAPTGP VQTPYQPTPS PGPNPYGTPA PAAHSPAYGY 

       370        380        390        400        410        420 
PQQAGYQTPA PAPYAQQQAA ATPPPYNLTP SAQGSGSGSP GGKSNKPVII GSIVVAVVAV 

       430        440        450        460        470        480 
GGLIGALLMN GGGDEDPEAG GGGSSTASVS ASPSKAAGYR GPDKEKTIEK DKCTEPQESY 

       490        500        510        520        530        540 
NDPDKIQVPD FTFKYIGSVK ECFNAAGWQM KVVEVDENTY GEGSVRDQFP TAGTDVDPEN 

       550 
MPEIQLKVST GNPPSE 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, nucleotide sequence and expression of a serine/threonine protein kinase gene from Streptomyces coelicolor."
Bakal C.J., Davies J.E.
Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: A3(2) / NRRL B-16638.
[2]"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)."
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. expand/collapse author list , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.
Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF094711 Genomic DNA. Translation: AAC64406.1.
AL939117 Genomic DNA. Translation: CAB46944.1.
PIRT36502.
T42100.
RefSeqNP_628010.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9S2C0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO3821.

PTM databases

PhosSiteP1007956.

Proteomic databases

PRIDEQ9S2C0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB46944; CAB46944; CAB46944.
GeneID1099257.
KEGGsco:SCO3821.
PATRIC23737410. VBIStrCoe124346_3889.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000037185.
OMAAIAYAHV.
OrthoDBEOG6B35XT.
PhylomeDBQ9S2C0.
ProtClustDBCLSK224339.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR005543. PASTA.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF03793. PASTA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTSM00740. PASTA. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS51178. PASTA. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePKSC_STRCO
AccessionPrimary (citable) accession number: Q9S2C0
Secondary accession number(s): Q9ZFS8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families