Q9S2C0 (PKSC_STRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein kinase PksC
EC=2.7.11.1

Gene names

Name:	pksC
Ordered Locus Names:	SCO3821
ORF Names:	SCGD3.22

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]

Taxonomic identifier

100226 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces › Streptomyces coelicolor

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Contains 1 PASTA domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW penicillin binding Inferred from electronic annotation. Source: InterPro protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Serine/threonine-protein kinase PksC		PRO_0000171236
Regions
	Domain	20 – 287	268	Protein kinase
	Domain	482 – 550	69	PASTA
	Nucleotide binding	26 – 34	9	ATP By similarity
	Compositional bias	318 – 390	73	Pro-rich
Sites
	Active site	151	1	Proton acceptor By similarity
	Binding site	49	1	ATP By similarity
Experimental info
	Sequence conflict	80	1	I → M in AAC64406. Ref.1
	Sequence conflict	99	1	I → L in AAC64406. Ref.1
	Sequence conflict	110	1	G → C in AAC64406. Ref.1
	Sequence conflict	147	1	L → V in AAC64406. Ref.1
	Sequence conflict	339	1	P → L in AAC64406. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9S2C0 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D4A22A2F39F4ADC1	FASTA	556	58,262
	10 20 30 40 50 60 MSQDGGQGRY AGRALAGGRY QLRDLLGEGG MASVHLAYDS VLDRQVAIKT LHTELGREQA 70 80 90 100 110 120 FRERFRREAQ AVAKLTHTNI VSVFDTGEDD LDGMTTPYIV MEYVEGRPLG SVLDEDVRQQ 130 140 150 160 170 180 GAMPADKALK ITADVLAALE ISHEMGLVHR DIKPGNVMMT KRGVVKVMDF GIARAMQSGV 190 200 210 220 230 240 TSMTQTGMVV GTPQYLSPEQ ALGRGVDARS DLYSVGIMLF QLVTGRLPFD ADSPLAIAYA 250 260 270 280 290 300 HVQEQPVAPS AVNRALPPAV DALVARALKK NPNERFPSAE AMRDECLRVA ASFQAAPPSI 310 320 330 340 350 360 VPGAQTSSGA GVGSAVFPPV GQGTPAPTGP VQTPYQPTPS PGPNPYGTPA PAAHSPAYGY 370 380 390 400 410 420 PQQAGYQTPA PAPYAQQQAA ATPPPYNLTP SAQGSGSGSP GGKSNKPVII GSIVVAVVAV 430 440 450 460 470 480 GGLIGALLMN GGGDEDPEAG GGGSSTASVS ASPSKAAGYR GPDKEKTIEK DKCTEPQESY 490 500 510 520 530 540 NDPDKIQVPD FTFKYIGSVK ECFNAAGWQM KVVEVDENTY GEGSVRDQFP TAGTDVDPEN 550 MPEIQLKVST GNPPSE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, nucleotide sequence and expression of a serine/threonine protein kinase gene from Streptomyces coelicolor." Bakal C.J., Davies J.E. Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: A3(2) / NRRL B-16638.
[2]	"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF094711 Genomic DNA. Translation: AAC64406.1. AL939117 Genomic DNA. Translation: CAB46944.1.
PIR	T36502. T42100.
RefSeq	NP_628010.1. NC_003888.3.
3D structure databases
ProteinModelPortal	Q9S2C0.
ModBase	Search...
Protein-protein interaction databases
STRING	100226.SCO3821.
PTM databases
PhosSite	P1007956.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB46944; CAB46944; CAB46944.
GeneID	1099257.
KEGG	sco:SCO3821.
PATRIC	23737410. VBIStrCoe124346_3889.
Phylogenomic databases
eggNOG	COG0515.
HOGENOM	HOG000037185.
OMA	AIAYAHV.
ProtClustDB	CLSK224339.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR005543. PASTA. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
Pfam	PF03793. PASTA. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00740. PASTA. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS51178. PASTA. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PKSC_STRCO

Accession

Primary (citable) accession number: Q9S2C0
Secondary accession number(s): Q9ZFS8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 4, 2003
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program