Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9S2C0

- PKSC_STRCO

UniProt

Q9S2C0 - PKSC_STRCO

Protein

Serine/threonine-protein kinase PksC

Gene

pksC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei49 – 491ATPPROSITE-ProRule annotation
    Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. penicillin binding Source: InterPro
    3. protein serine/threonine kinase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase PksC (EC:2.7.11.1)
    Gene namesi
    Name:pksC
    Ordered Locus Names:SCO3821
    ORF Names:SCGD3.22
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 556556Serine/threonine-protein kinase PksCPRO_0000171236Add
    BLAST

    Proteomic databases

    PRIDEiQ9S2C0.

    PTM databases

    PhosSiteiP1007956.

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO3821.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9S2C0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 287268Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini482 – 55069PASTAPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi318 – 39073Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
    Contains 1 PASTA domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000037185.
    OMAiGVTSMTQ.
    OrthoDBiEOG6B35XT.
    PhylomeDBiQ9S2C0.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF03793. PASTA. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00740. PASTA. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS51178. PASTA. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9S2C0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQDGGQGRY AGRALAGGRY QLRDLLGEGG MASVHLAYDS VLDRQVAIKT    50
    LHTELGREQA FRERFRREAQ AVAKLTHTNI VSVFDTGEDD LDGMTTPYIV 100
    MEYVEGRPLG SVLDEDVRQQ GAMPADKALK ITADVLAALE ISHEMGLVHR 150
    DIKPGNVMMT KRGVVKVMDF GIARAMQSGV TSMTQTGMVV GTPQYLSPEQ 200
    ALGRGVDARS DLYSVGIMLF QLVTGRLPFD ADSPLAIAYA HVQEQPVAPS 250
    AVNRALPPAV DALVARALKK NPNERFPSAE AMRDECLRVA ASFQAAPPSI 300
    VPGAQTSSGA GVGSAVFPPV GQGTPAPTGP VQTPYQPTPS PGPNPYGTPA 350
    PAAHSPAYGY PQQAGYQTPA PAPYAQQQAA ATPPPYNLTP SAQGSGSGSP 400
    GGKSNKPVII GSIVVAVVAV GGLIGALLMN GGGDEDPEAG GGGSSTASVS 450
    ASPSKAAGYR GPDKEKTIEK DKCTEPQESY NDPDKIQVPD FTFKYIGSVK 500
    ECFNAAGWQM KVVEVDENTY GEGSVRDQFP TAGTDVDPEN MPEIQLKVST 550
    GNPPSE 556
    Length:556
    Mass (Da):58,262
    Last modified:May 1, 2000 - v1
    Checksum:iD4A22A2F39F4ADC1
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti80 – 801I → M in AAC64406. 1 PublicationCurated
    Sequence conflicti99 – 991I → L in AAC64406. 1 PublicationCurated
    Sequence conflicti110 – 1101G → C in AAC64406. 1 PublicationCurated
    Sequence conflicti147 – 1471L → V in AAC64406. 1 PublicationCurated
    Sequence conflicti339 – 3391P → L in AAC64406. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF094711 Genomic DNA. Translation: AAC64406.1.
    AL939117 Genomic DNA. Translation: CAB46944.1.
    PIRiT36502.
    T42100.
    RefSeqiNP_628010.1. NC_003888.3.
    WP_011029251.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB46944; CAB46944; CAB46944.
    GeneIDi1099257.
    KEGGisco:SCO3821.
    PATRICi23737410. VBIStrCoe124346_3889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF094711 Genomic DNA. Translation: AAC64406.1 .
    AL939117 Genomic DNA. Translation: CAB46944.1 .
    PIRi T36502.
    T42100.
    RefSeqi NP_628010.1. NC_003888.3.
    WP_011029251.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9S2C0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO3821.

    PTM databases

    PhosSitei P1007956.

    Proteomic databases

    PRIDEi Q9S2C0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB46944 ; CAB46944 ; CAB46944 .
    GeneIDi 1099257.
    KEGGi sco:SCO3821.
    PATRICi 23737410. VBIStrCoe124346_3889.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000037185.
    OMAi GVTSMTQ.
    OrthoDBi EOG6B35XT.
    PhylomeDBi Q9S2C0.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR005543. PASTA_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF03793. PASTA. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00740. PASTA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS51178. PASTA. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, nucleotide sequence and expression of a serine/threonine protein kinase gene from Streptomyces coelicolor."
      Bakal C.J., Davies J.E.
      Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: A3(2) / NRRL B-16638.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiPKSC_STRCO
    AccessioniPrimary (citable) accession number: Q9S2C0
    Secondary accession number(s): Q9ZFS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 4, 2003
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3