Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase PksC

Gene

pksC

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei49 – 491ATPPROSITE-ProRule annotation
Active sitei151 – 1511Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi26 – 349ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. penicillin binding Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase PksC (EC:2.7.11.1)
Gene namesi
Name:pksC
Ordered Locus Names:SCO3821
ORF Names:SCGD3.22
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 556556Serine/threonine-protein kinase PksCPRO_0000171236Add
BLAST

Proteomic databases

PRIDEiQ9S2C0.

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO3821.

Structurei

3D structure databases

ProteinModelPortaliQ9S2C0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 287268Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini482 – 55069PASTAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi318 – 39073Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation
Contains 1 PASTA domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037185.
InParanoidiQ9S2C0.
OMAiGVTSMTQ.
OrthoDBiEOG6B35XT.
PhylomeDBiQ9S2C0.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51178. PASTA. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9S2C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDGGQGRY AGRALAGGRY QLRDLLGEGG MASVHLAYDS VLDRQVAIKT
60 70 80 90 100
LHTELGREQA FRERFRREAQ AVAKLTHTNI VSVFDTGEDD LDGMTTPYIV
110 120 130 140 150
MEYVEGRPLG SVLDEDVRQQ GAMPADKALK ITADVLAALE ISHEMGLVHR
160 170 180 190 200
DIKPGNVMMT KRGVVKVMDF GIARAMQSGV TSMTQTGMVV GTPQYLSPEQ
210 220 230 240 250
ALGRGVDARS DLYSVGIMLF QLVTGRLPFD ADSPLAIAYA HVQEQPVAPS
260 270 280 290 300
AVNRALPPAV DALVARALKK NPNERFPSAE AMRDECLRVA ASFQAAPPSI
310 320 330 340 350
VPGAQTSSGA GVGSAVFPPV GQGTPAPTGP VQTPYQPTPS PGPNPYGTPA
360 370 380 390 400
PAAHSPAYGY PQQAGYQTPA PAPYAQQQAA ATPPPYNLTP SAQGSGSGSP
410 420 430 440 450
GGKSNKPVII GSIVVAVVAV GGLIGALLMN GGGDEDPEAG GGGSSTASVS
460 470 480 490 500
ASPSKAAGYR GPDKEKTIEK DKCTEPQESY NDPDKIQVPD FTFKYIGSVK
510 520 530 540 550
ECFNAAGWQM KVVEVDENTY GEGSVRDQFP TAGTDVDPEN MPEIQLKVST

GNPPSE
Length:556
Mass (Da):58,262
Last modified:May 1, 2000 - v1
Checksum:iD4A22A2F39F4ADC1
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti80 – 801I → M in AAC64406 (Ref. 1) Curated
Sequence conflicti99 – 991I → L in AAC64406 (Ref. 1) Curated
Sequence conflicti110 – 1101G → C in AAC64406 (Ref. 1) Curated
Sequence conflicti147 – 1471L → V in AAC64406 (Ref. 1) Curated
Sequence conflicti339 – 3391P → L in AAC64406 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094711 Genomic DNA. Translation: AAC64406.1.
AL939117 Genomic DNA. Translation: CAB46944.1.
PIRiT36502.
T42100.
RefSeqiNP_628010.1. NC_003888.3.
WP_011029251.1. NC_003888.3.

Genome annotation databases

GeneIDi1099257.
KEGGisco:SCO3821.
PATRICi23737410. VBIStrCoe124346_3889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF094711 Genomic DNA. Translation: AAC64406.1.
AL939117 Genomic DNA. Translation: CAB46944.1.
PIRiT36502.
T42100.
RefSeqiNP_628010.1. NC_003888.3.
WP_011029251.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9S2C0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO3821.

Proteomic databases

PRIDEiQ9S2C0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1099257.
KEGGisco:SCO3821.
PATRICi23737410. VBIStrCoe124346_3889.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000037185.
InParanoidiQ9S2C0.
OMAiGVTSMTQ.
OrthoDBiEOG6B35XT.
PhylomeDBiQ9S2C0.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR005543. PASTA_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF03793. PASTA. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00740. PASTA. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS51178. PASTA. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, nucleotide sequence and expression of a serine/threonine protein kinase gene from Streptomyces coelicolor."
    Bakal C.J., Davies J.E.
    Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: A3(2) / NRRL B-16638.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiPKSC_STRCO
AccessioniPrimary (citable) accession number: Q9S2C0
Secondary accession number(s): Q9ZFS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 4, 2003
Last sequence update: May 1, 2000
Last modified: April 29, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.