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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathwayi: L-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei297Proton acceptorUniRule annotation1
Metal bindingi340IronUniRule annotation1
Metal bindingi346IronUniRule annotation1
Binding sitei355homogentisateUniRule annotation1
Metal bindingi376IronUniRule annotation1
Binding sitei376homogentisateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processPhenylalanine catabolism, Tyrosine catabolism
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Synonyms:hgd
Ordered Locus Names:SCO1715
ORF Names:SCI11.04
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
Proteomesi
  • UP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002202561 – 441Homogentisate 1,2-dioxygenaseAdd BLAST441

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO1715

Structurei

3D structure databases

ProteinModelPortaliQ9S2B5
SMRiQ9S2B5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F1J Bacteria
COG3508 LUCA
HOGENOMiHOG000139824
InParanoidiQ9S2B5
KOiK00451
OMAiHGNYTPY
OrthoDBiPOG091H04E0
PhylomeDBiQ9S2B5

Family and domain databases

Gene3Di2.60.120.10, 1 hit
HAMAPiMF_00334 Homogentis_dioxygen, 1 hit
InterProiView protein in InterPro
IPR005708 Homogentis_dOase
IPR022950 Homogentis_dOase_bac
IPR014710 RmlC-like_jellyroll
IPR011051 RmlC_Cupin_sf
PANTHERiPTHR11056 PTHR11056, 1 hit
PfamiView protein in Pfam
PF04209 HgmA, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit
TIGRFAMsiTIGR01015 hmgA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9S2B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDARKTAE GLAYLSGFGN EHASEAVAGA LPEGRNSPQR APLGLYAEQL
60 70 80 90 100
SGTAFTEPRA HNRRSWLYRI RPSAAHPAFT RSGNGTIRTA PFNQAVPDPN
110 120 130 140 150
RLRWNPLPVP GPATDFVEGL WTLGGNGDAT QRTGMAVHLY HATASMDRVF
160 170 180 190 200
SDADGELLIV PERGGLLLRT EFGLLHAEPG HVALIPRGVR FRVQLLDEDA
210 220 230 240 250
RGYVCENYGA PFQLPDLGPI GANGLANARD FRAPVAAYED DESTPGPVEV
260 270 280 290 300
VNKFCGNLWT AEYDHSPLDV VAWHGNHVPY VYDLRRFNVI GSISYDHPDP
310 320 330 340 350
SIFTVLTSPS DTPGLAGVDF VVFAPRWLVG EDTFRPPYFH RNVMSEYMGL
360 370 380 390 400
IEGAYDAKAE GFVPGGGSLH NMMSAHGPDR ETFDRASAAE LKPQRIDDGL
410 420 430 440
AFMFETRWPV TLTPQAARAE HLQPGYDDVW QGLERHFRPL H
Length:441
Mass (Da):48,418
Last modified:May 1, 2000 - v1
Checksum:i52161616024FFD5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA Translation: CAB50930.1
PIRiT36737
RefSeqiNP_625988.1, NC_003888.3
WP_003977111.1, NC_003888.3

Genome annotation databases

EnsemblBacteriaiCAB50930; CAB50930; CAB50930
GeneIDi1097146
KEGGisco:SCO1715
PATRICifig|100226.15.peg.1732

Similar proteinsi

Entry informationi

Entry nameiHGD_STRCO
AccessioniPrimary (citable) accession number: Q9S2B5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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