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Q9S2B5

- HGD_STRCO

UniProt

Q9S2B5 - HGD_STRCO

Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

    Catalytic activityi

    Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

    Cofactori

    Iron.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei297 – 2971Proton acceptorUniRule annotation
    Metal bindingi340 – 3401IronUniRule annotation
    Metal bindingi346 – 3461IronUniRule annotation
    Binding sitei355 – 3551homogentisateUniRule annotation
    Metal bindingi376 – 3761IronUniRule annotation
    Binding sitei376 – 3761homogentisateUniRule annotation

    GO - Molecular functioni

    1. homogentisate 1,2-dioxygenase activity Source: UniProtKB-HAMAP
    2. iron ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-phenylalanine catabolic process Source: UniProtKB-HAMAP
    2. tyrosine catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Phenylalanine catabolism, Tyrosine catabolism

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00139; UER00339.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
    Short name:
    HGDOUniRule annotation
    Alternative name(s):
    Homogentisate oxygenaseUniRule annotation
    Homogentisic acid oxidaseUniRule annotation
    HomogentisicaseUniRule annotation
    Gene namesi
    Name:hmgAUniRule annotation
    Synonyms:hgd
    Ordered Locus Names:SCO1715
    ORF Names:SCI11.04
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 441441Homogentisate 1,2-dioxygenasePRO_0000220256Add
    BLAST

    Interactioni

    Subunit structurei

    Hexamer; dimer of trimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi100226.SCO1715.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9S2B5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the homogentisate dioxygenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3508.
    HOGENOMiHOG000139824.
    KOiK00451.
    OMAiRCFYNSD.
    OrthoDBiEOG6D5FZK.
    PhylomeDBiQ9S2B5.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00334. Homogentis_dioxygen.
    InterProiIPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR11056. PTHR11056. 1 hit.
    PfamiPF04209. HgmA. 1 hit.
    [Graphical view]
    SUPFAMiSSF51182. SSF51182. 1 hit.
    TIGRFAMsiTIGR01015. hmgA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9S2B5-1 [UniParc]FASTAAdd to Basket

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    MSGDARKTAE GLAYLSGFGN EHASEAVAGA LPEGRNSPQR APLGLYAEQL    50
    SGTAFTEPRA HNRRSWLYRI RPSAAHPAFT RSGNGTIRTA PFNQAVPDPN 100
    RLRWNPLPVP GPATDFVEGL WTLGGNGDAT QRTGMAVHLY HATASMDRVF 150
    SDADGELLIV PERGGLLLRT EFGLLHAEPG HVALIPRGVR FRVQLLDEDA 200
    RGYVCENYGA PFQLPDLGPI GANGLANARD FRAPVAAYED DESTPGPVEV 250
    VNKFCGNLWT AEYDHSPLDV VAWHGNHVPY VYDLRRFNVI GSISYDHPDP 300
    SIFTVLTSPS DTPGLAGVDF VVFAPRWLVG EDTFRPPYFH RNVMSEYMGL 350
    IEGAYDAKAE GFVPGGGSLH NMMSAHGPDR ETFDRASAAE LKPQRIDDGL 400
    AFMFETRWPV TLTPQAARAE HLQPGYDDVW QGLERHFRPL H 441
    Length:441
    Mass (Da):48,418
    Last modified:May 1, 2000 - v1
    Checksum:i52161616024FFD5F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939110 Genomic DNA. Translation: CAB50930.1.
    PIRiT36737.
    RefSeqiNP_625988.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB50930; CAB50930; CAB50930.
    GeneIDi1097146.
    KEGGisco:SCO1715.
    PATRICi23733038. VBIStrCoe124346_1732.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939110 Genomic DNA. Translation: CAB50930.1 .
    PIRi T36737.
    RefSeqi NP_625988.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9S2B5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO1715.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB50930 ; CAB50930 ; CAB50930 .
    GeneIDi 1097146.
    KEGGi sco:SCO1715.
    PATRICi 23733038. VBIStrCoe124346_1732.

    Phylogenomic databases

    eggNOGi COG3508.
    HOGENOMi HOG000139824.
    KOi K00451.
    OMAi RCFYNSD.
    OrthoDBi EOG6D5FZK.
    PhylomeDBi Q9S2B5.

    Enzyme and pathway databases

    UniPathwayi UPA00139 ; UER00339 .

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00334. Homogentis_dioxygen.
    InterProi IPR005708. Homogentis_dOase.
    IPR022950. Homogentis_dOase_bac.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR11056. PTHR11056. 1 hit.
    Pfami PF04209. HgmA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51182. SSF51182. 1 hit.
    TIGRFAMsi TIGR01015. hmgA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiHGD_STRCO
    AccessioniPrimary (citable) accession number: Q9S2B5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3