Reviewed, UniProtKB/Swiss-Prot Q9S2B5 (HGD_STRCO)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Synonyms:	hgd
Ordered Locus Names:	SCO1715
ORF Names:	SCI11.04

Organism

Streptomyces coelicolor [Complete proteome] [HAMAP]

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity. HAMAP MF_00334
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_0000220256
Sites
	Metal binding	340	1	Iron By similarity
	Metal binding	346	1	Iron By similarity
	Metal binding	376	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9S2B5-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 52161616024FFD5F	FASTA	441	48,418
	10 20 30 40 50 60 MSGDARKTAE GLAYLSGFGN EHASEAVAGA LPEGRNSPQR APLGLYAEQL SGTAFTEPRA 70 80 90 100 110 120 HNRRSWLYRI RPSAAHPAFT RSGNGTIRTA PFNQAVPDPN RLRWNPLPVP GPATDFVEGL 130 140 150 160 170 180 WTLGGNGDAT QRTGMAVHLY HATASMDRVF SDADGELLIV PERGGLLLRT EFGLLHAEPG 190 200 210 220 230 240 HVALIPRGVR FRVQLLDEDA RGYVCENYGA PFQLPDLGPI GANGLANARD FRAPVAAYED 250 260 270 280 290 300 DESTPGPVEV VNKFCGNLWT AEYDHSPLDV VAWHGNHVPY VYDLRRFNVI GSISYDHPDP 310 320 330 340 350 360 SIFTVLTSPS DTPGLAGVDF VVFAPRWLVG EDTFRPPYFH RNVMSEYMGL IEGAYDAKAE 370 380 390 400 410 420 GFVPGGGSLH NMMSAHGPDR ETFDRASAAE LKPQRIDDGL AFMFETRWPV TLTPQAARAE 430 440 HLQPGYDDVW QGLERHFRPL H

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939110 Genomic DNA. Translation: CAB50930.1.
PIR	T36737.
RefSeq	NP_625988.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1097146.
KEGG	sco:SCO1715.
NMPDR	fig|100226.1.peg.1682.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG293508.
OMA	RNCMSEF.
Enzyme and pathway databases
BioCyc	SCOE100226:SCO1715-MONOMER.
BRENDA	1.13.11.5. 1084.
Family and domain databases
HAMAP	MF_00334. Homogentis_dioxygen. [Tree]
InterPro	IPR011051. Cupin_RmlC_type. IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_STRCO

Accession

Primary (citable) accession number: Q9S2B5

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)