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Q9S2B5 (HGD_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

Short name=HGDO
EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Synonyms:hgd
Ordered Locus Names:SCO1715
ORF Names:SCI11.04
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length441 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate By similarity. HAMAP-Rule MF_00334

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Subunit structure

Hexamer; dimer of trimers By similarity. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 441441Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000220256

Sites

Active site2971Proton acceptor By similarity
Metal binding3401Iron By similarity
Metal binding3461Iron By similarity
Metal binding3761Iron By similarity
Binding site3551homogentisate By similarity
Binding site3761homogentisate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9S2B5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 52161616024FFD5F

FASTA44148,418
        10         20         30         40         50         60 
MSGDARKTAE GLAYLSGFGN EHASEAVAGA LPEGRNSPQR APLGLYAEQL SGTAFTEPRA 

        70         80         90        100        110        120 
HNRRSWLYRI RPSAAHPAFT RSGNGTIRTA PFNQAVPDPN RLRWNPLPVP GPATDFVEGL 

       130        140        150        160        170        180 
WTLGGNGDAT QRTGMAVHLY HATASMDRVF SDADGELLIV PERGGLLLRT EFGLLHAEPG 

       190        200        210        220        230        240 
HVALIPRGVR FRVQLLDEDA RGYVCENYGA PFQLPDLGPI GANGLANARD FRAPVAAYED 

       250        260        270        280        290        300 
DESTPGPVEV VNKFCGNLWT AEYDHSPLDV VAWHGNHVPY VYDLRRFNVI GSISYDHPDP 

       310        320        330        340        350        360 
SIFTVLTSPS DTPGLAGVDF VVFAPRWLVG EDTFRPPYFH RNVMSEYMGL IEGAYDAKAE 

       370        380        390        400        410        420 
GFVPGGGSLH NMMSAHGPDR ETFDRASAAE LKPQRIDDGL AFMFETRWPV TLTPQAARAE 

       430        440 
HLQPGYDDVW QGLERHFRPL H 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939110 Genomic DNA. Translation: CAB50930.1.
PIRT36737.
RefSeqNP_625988.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9S2B5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO1715.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB50930; CAB50930; CAB50930.
GeneID1097146.
KEGGsco:SCO1715.
PATRIC23733038. VBIStrCoe124346_1732.

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMARCFYNSD.
OrthoDBEOG6D5FZK.
PhylomeDBQ9S2B5.

Enzyme and pathway databases

UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_STRCO
AccessionPrimary (citable) accession number: Q9S2B5
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways