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Protein

Homogentisate 1,2-dioxygenase

Gene

hmgA

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the catabolism of homogentisate (2,5-dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate.UniRule annotation

Catalytic activityi

Homogentisate + O2 = 4-maleylacetoacetate.UniRule annotation

Cofactori

Fe cationUniRule annotation

Pathway:iL-phenylalanine degradation

This protein is involved in step 4 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hmgA)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei297 – 2971Proton acceptorUniRule annotation
Metal bindingi340 – 3401IronUniRule annotation
Metal bindingi346 – 3461IronUniRule annotation
Binding sitei355 – 3551homogentisateUniRule annotation
Metal bindingi376 – 3761IronUniRule annotation
Binding sitei376 – 3761homogentisateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.

Names & Taxonomyi

Protein namesi
Recommended name:
Homogentisate 1,2-dioxygenaseUniRule annotation (EC:1.13.11.5UniRule annotation)
Short name:
HGDOUniRule annotation
Alternative name(s):
Homogentisate oxygenaseUniRule annotation
Homogentisic acid oxidaseUniRule annotation
HomogentisicaseUniRule annotation
Gene namesi
Name:hmgAUniRule annotation
Synonyms:hgd
Ordered Locus Names:SCO1715
ORF Names:SCI11.04
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 441441Homogentisate 1,2-dioxygenasePRO_0000220256Add
BLAST

Interactioni

Subunit structurei

Hexamer; dimer of trimers.UniRule annotation

Protein-protein interaction databases

STRINGi100226.SCO1715.

Structurei

3D structure databases

ProteinModelPortaliQ9S2B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the homogentisate dioxygenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ9S2B5.
KOiK00451.
OMAiRGYLCEN.
OrthoDBiEOG6D5FZK.
PhylomeDBiQ9S2B5.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S2B5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGDARKTAE GLAYLSGFGN EHASEAVAGA LPEGRNSPQR APLGLYAEQL
60 70 80 90 100
SGTAFTEPRA HNRRSWLYRI RPSAAHPAFT RSGNGTIRTA PFNQAVPDPN
110 120 130 140 150
RLRWNPLPVP GPATDFVEGL WTLGGNGDAT QRTGMAVHLY HATASMDRVF
160 170 180 190 200
SDADGELLIV PERGGLLLRT EFGLLHAEPG HVALIPRGVR FRVQLLDEDA
210 220 230 240 250
RGYVCENYGA PFQLPDLGPI GANGLANARD FRAPVAAYED DESTPGPVEV
260 270 280 290 300
VNKFCGNLWT AEYDHSPLDV VAWHGNHVPY VYDLRRFNVI GSISYDHPDP
310 320 330 340 350
SIFTVLTSPS DTPGLAGVDF VVFAPRWLVG EDTFRPPYFH RNVMSEYMGL
360 370 380 390 400
IEGAYDAKAE GFVPGGGSLH NMMSAHGPDR ETFDRASAAE LKPQRIDDGL
410 420 430 440
AFMFETRWPV TLTPQAARAE HLQPGYDDVW QGLERHFRPL H
Length:441
Mass (Da):48,418
Last modified:May 1, 2000 - v1
Checksum:i52161616024FFD5F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA. Translation: CAB50930.1.
PIRiT36737.
RefSeqiNP_625988.1. NC_003888.3.
WP_003977111.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB50930; CAB50930; CAB50930.
GeneIDi1097146.
KEGGisco:SCO1715.
PATRICi23733038. VBIStrCoe124346_1732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA. Translation: CAB50930.1.
PIRiT36737.
RefSeqiNP_625988.1. NC_003888.3.
WP_003977111.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9S2B5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1715.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB50930; CAB50930; CAB50930.
GeneIDi1097146.
KEGGisco:SCO1715.
PATRICi23733038. VBIStrCoe124346_1732.

Phylogenomic databases

eggNOGiCOG3508.
HOGENOMiHOG000139824.
InParanoidiQ9S2B5.
KOiK00451.
OMAiRGYLCEN.
OrthoDBiEOG6D5FZK.
PhylomeDBiQ9S2B5.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00339.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00334. Homogentis_dioxygen.
InterProiIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR11056. PTHR11056. 1 hit.
PfamiPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMiSSF51182. SSF51182. 1 hit.
TIGRFAMsiTIGR01015. hmgA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiHGD_STRCO
AccessioniPrimary (citable) accession number: Q9S2B5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.