Q9S227 (Q9S227_STRCO) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183

Gene names

Ordered Locus Names:

SCO1773

Organism

Streptomyces coelicolor

Taxonomic identifier

1902 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Streptomycineae › Streptomycetaceae › Streptomyces

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183
Pathway	Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183
Sequence similarities	Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
Ligand	NAD PIRNR PIRNR000183
Molecular function	Oxidoreductase PIRNR PIRNR000183
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	alanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9S227 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D8533893A0CFE8FD	FASTA	371	39,571
	10 20 30 40 50 60 MKVGIPREVK NNEFRVAITP AGVHELVRHG HQVVVERNAG VGSSIPDEEY VTAGARILDT 70 80 90 100 110 120 ADEVWATADL LLKVKEPIAE EYHRLRKDQT LFTYLHLAAS KECTDALIES RTTAIAYETV 130 140 150 160 170 180 ELPSRALPLL APMSEVAGRL APQVGAYHLM AANGGRGVLP GGVPGVLAGR AVVIGGGVSG 190 200 210 220 230 240 WNAAQIAIGL GFHVTLLDKD ITKLREADKI FGTKIQTVVS NAFELEKACL EADLVIGAVL 250 260 270 280 290 300 IPGAKAPKLV TNELVSRMKP GSVLVDIAID QGGCFEDSHP TTHAEPTFPV HNSVFYCVAN 310 320 330 340 350 360 MPGAVPNTST YALTNATLPY IVELADRGWA EALRRDPALA KGLNTHDGKV VYREVAEAHG 370 LEHVELASLL A

References

[1]

"Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)." Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A., Fraser A., Goble A. , Hidalgo J., Hornsby T., Howarth S., Huang C.-H., Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E., Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D., Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A., Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A. Nature 417:141-147(2002) [PubMed: 12000953] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-471 / A3(2) / M145.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL939110 Genomic DNA. Translation: CAB52837.1.
PIR	T36876.
RefSeq	NP_626044.1. NC_003888.3.
3D structure databases
HSSP	HSSP built from PDB template 1SAY based on UniProtKB O52942.
ProteinModelPortal	Q9S227.
SMR	Q9S227. Positions 1-371.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1097204.
GenomeReviews	Gene locus SCO1773 in contig AL645882_GR.
KEGG	sco:SCO1773.
NMPDR	fig|100226.1.peg.1740.
PATRIC	23733154. VBIStrCoe124346_1790.
Phylogenomic databases
HOGENOM	HBG289735.
OMA	VAHGHEV.
PhylomeDB	Q9S227.
ProtClustDB	CLSK2303389.
Family and domain databases
InterPro	IPR008142. Ala_DH/PNT_CS1. IPR008141. Ala_DH/Pyr_transHydgase. IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. [Graphical view]
KO	K00259.
PANTHER	PTHR10160:SF3. PTHR10160:SF3. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PIRSF	PIRSF000183. Alanine_dh. 1 hit.
SMART	SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00518. AlaDH. 1 hit.
PROSITE	PS00836. ALADH_PNT_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9S227_STRCO

Accession

Primary (citable) accession number: Q9S227

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)