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Protein

NAD kinase 2

Gene

nadK2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771Proton acceptorUniRule annotation
Binding sitei82 – 821NADUniRule annotation
Binding sitei162 – 1621NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 782NADUniRule annotation
Nucleotide bindingi151 – 1522NADUniRule annotation
Nucleotide bindingi192 – 1976NADUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:SCO1781
ORF Names:SCI51.21c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301NAD kinase 2PRO_0000120669Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1781.

Structurei

3D structure databases

ProteinModelPortaliQ9S219.
SMRiQ9S219. Positions 7-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
InParanoidiQ9S219.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ9S219.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S219-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQNRVRTVF LLAHTGRPAA IRSAELVVKG LLRAGIGVRV LEAEARDLPL
60 70 80 90 100
PGEVELVGEA TPQCLDGCEL LIVLGGDGTL LRGAEFARAS GVPMLGVNLG
110 120 130 140 150
RVGFLAEAER DDLDKVVDRV VNRAYEVEER MTVDVVVHRN GDIVHTDWAL
160 170 180 190 200
NEAAVQKAGA EKLLEVVLEI DGRPVTGFGC DGIVLSTPTG STAYAFSAGG
210 220 230 240 250
PVVWPEVEAL LMVPISAHAL FAKPLVTSPD SVLAVEVLPH VPPGVLWCDG
260 270 280 290 300
RRTVELPPGA RVEVRRGAVP VRLARLHHAS FTDRLVAKFA LPVSGWRGAP

H
Length:301
Mass (Da):32,081
Last modified:May 1, 2000 - v1
Checksum:iFCB6F6B01766AFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA. Translation: CAB52845.1.
PIRiT36884.
RefSeqiNP_626052.1. NC_003888.3.
WP_011027973.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB52845; CAB52845; CAB52845.
GeneIDi1097212.
KEGGisco:SCO1781.
PATRICi23733174. VBIStrCoe124346_1800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL939110 Genomic DNA. Translation: CAB52845.1.
PIRiT36884.
RefSeqiNP_626052.1. NC_003888.3.
WP_011027973.1. NC_003888.3.

3D structure databases

ProteinModelPortaliQ9S219.
SMRiQ9S219. Positions 7-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi100226.SCO1781.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB52845; CAB52845; CAB52845.
GeneIDi1097212.
KEGGisco:SCO1781.
PATRICi23733174. VBIStrCoe124346_1800.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
InParanoidiQ9S219.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ9S219.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR016064. NAD/diacylglycerol_kinase.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiNADK2_STRCO
AccessioniPrimary (citable) accession number: Q9S219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.