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Q9S219 (NADK2_STRCO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase 2

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase 2
Gene names
Name:nadK2
Ordered Locus Names:SCO1781
ORF Names:SCI51.21c
OrganismStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) [Reference proteome] [HAMAP]
Taxonomic identifier100226 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group

Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 301301NAD kinase 2 HAMAP-Rule MF_00361
PRO_0000120669

Regions

Nucleotide binding77 – 782NAD By similarity
Nucleotide binding151 – 1522NAD By similarity
Nucleotide binding192 – 1976NAD By similarity

Sites

Active site771Proton acceptor By similarity
Binding site821NAD By similarity
Binding site1621NAD By similarity
Binding site1811NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9S219 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: FCB6F6B01766AFBA

FASTA30132,081
        10         20         30         40         50         60 
MTQNRVRTVF LLAHTGRPAA IRSAELVVKG LLRAGIGVRV LEAEARDLPL PGEVELVGEA 

        70         80         90        100        110        120 
TPQCLDGCEL LIVLGGDGTL LRGAEFARAS GVPMLGVNLG RVGFLAEAER DDLDKVVDRV 

       130        140        150        160        170        180 
VNRAYEVEER MTVDVVVHRN GDIVHTDWAL NEAAVQKAGA EKLLEVVLEI DGRPVTGFGC 

       190        200        210        220        230        240 
DGIVLSTPTG STAYAFSAGG PVVWPEVEAL LMVPISAHAL FAKPLVTSPD SVLAVEVLPH 

       250        260        270        280        290        300 
VPPGVLWCDG RRTVELPPGA RVEVRRGAVP VRLARLHHAS FTDRLVAKFA LPVSGWRGAP 


H 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL939110 Genomic DNA. Translation: CAB52845.1.
PIRT36884.
RefSeqNP_626052.1. NC_003888.3.

3D structure databases

ProteinModelPortalQ9S219.
SMRQ9S219. Positions 7-297.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING100226.SCO1781.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAB52845; CAB52845; CAB52845.
GeneID1097212.
KEGGsco:SCO1781.
PATRIC23733174. VBIStrCoe124346_1800.

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227223.
KOK00858.
OMAGVLWCDG.
OrthoDBEOG6PZXDR.
PhylomeDBQ9S219.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK2_STRCO
AccessionPrimary (citable) accession number: Q9S219
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families