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Q9S219

- NADK2_STRCO

UniProt

Q9S219 - NADK2_STRCO

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Protein

NAD kinase 2

Gene

nadK2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei77 – 771Proton acceptorUniRule annotation
Binding sitei82 – 821NADUniRule annotation
Binding sitei162 – 1621NADUniRule annotation
Binding sitei181 – 1811NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi77 – 782NADUniRule annotation
Nucleotide bindingi151 – 1522NADUniRule annotation
Nucleotide bindingi192 – 1976NADUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-HAMAP
  3. NAD+ kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinase 2UniRule annotation
Gene namesi
Name:nadK2UniRule annotation
Ordered Locus Names:SCO1781
ORF Names:SCI51.21c
OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Taxonomic identifieri100226 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
ProteomesiUP000001973: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301NAD kinase 2PRO_0000120669Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi100226.SCO1781.

Structurei

3D structure databases

ProteinModelPortaliQ9S219.
SMRiQ9S219. Positions 7-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000227223.
InParanoidiQ9S219.
KOiK00858.
OMAiGVLWCDG.
OrthoDBiEOG6PZXDR.
PhylomeDBiQ9S219.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9S219-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTQNRVRTVF LLAHTGRPAA IRSAELVVKG LLRAGIGVRV LEAEARDLPL
60 70 80 90 100
PGEVELVGEA TPQCLDGCEL LIVLGGDGTL LRGAEFARAS GVPMLGVNLG
110 120 130 140 150
RVGFLAEAER DDLDKVVDRV VNRAYEVEER MTVDVVVHRN GDIVHTDWAL
160 170 180 190 200
NEAAVQKAGA EKLLEVVLEI DGRPVTGFGC DGIVLSTPTG STAYAFSAGG
210 220 230 240 250
PVVWPEVEAL LMVPISAHAL FAKPLVTSPD SVLAVEVLPH VPPGVLWCDG
260 270 280 290 300
RRTVELPPGA RVEVRRGAVP VRLARLHHAS FTDRLVAKFA LPVSGWRGAP

H
Length:301
Mass (Da):32,081
Last modified:May 1, 2000 - v1
Checksum:iFCB6F6B01766AFBA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939110 Genomic DNA. Translation: CAB52845.1.
PIRiT36884.
RefSeqiNP_626052.1. NC_003888.3.

Genome annotation databases

EnsemblBacteriaiCAB52845; CAB52845; CAB52845.
GeneIDi1097212.
KEGGisco:SCO1781.
PATRICi23733174. VBIStrCoe124346_1800.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL939110 Genomic DNA. Translation: CAB52845.1 .
PIRi T36884.
RefSeqi NP_626052.1. NC_003888.3.

3D structure databases

ProteinModelPortali Q9S219.
SMRi Q9S219. Positions 7-297.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 100226.SCO1781.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB52845 ; CAB52845 ; CAB52845 .
GeneIDi 1097212.
KEGGi sco:SCO1781.
PATRICi 23733174. VBIStrCoe124346_1800.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000227223.
InParanoidi Q9S219.
KOi K00858.
OMAi GVLWCDG.
OrthoDBi EOG6PZXDR.
PhylomeDBi Q9S219.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-471 / A3(2) / M145.

Entry informationi

Entry nameiNADK2_STRCO
AccessioniPrimary (citable) accession number: Q9S219
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3