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Q9S219

- NADK2_STRCO

UniProt

Q9S219 - NADK2_STRCO

Protein

NAD kinase 2

Gene

nadK2

Organism
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei77 – 771Proton acceptorUniRule annotation
    Binding sitei82 – 821NADUniRule annotation
    Binding sitei162 – 1621NADUniRule annotation
    Binding sitei181 – 1811NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi77 – 782NADUniRule annotation
    Nucleotide bindingi151 – 1522NADUniRule annotation
    Nucleotide bindingi192 – 1976NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinase 2UniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinase 2UniRule annotation
    Gene namesi
    Name:nadK2UniRule annotation
    Ordered Locus Names:SCO1781
    ORF Names:SCI51.21c
    OrganismiStreptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
    Taxonomic identifieri100226 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomycesStreptomyces albidoflavus group
    ProteomesiUP000001973: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 301301NAD kinase 2PRO_0000120669Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi100226.SCO1781.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9S219.
    SMRiQ9S219. Positions 7-297.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000227223.
    KOiK00858.
    OMAiGVLWCDG.
    OrthoDBiEOG6PZXDR.
    PhylomeDBiQ9S219.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9S219-1 [UniParc]FASTAAdd to Basket

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    MTQNRVRTVF LLAHTGRPAA IRSAELVVKG LLRAGIGVRV LEAEARDLPL    50
    PGEVELVGEA TPQCLDGCEL LIVLGGDGTL LRGAEFARAS GVPMLGVNLG 100
    RVGFLAEAER DDLDKVVDRV VNRAYEVEER MTVDVVVHRN GDIVHTDWAL 150
    NEAAVQKAGA EKLLEVVLEI DGRPVTGFGC DGIVLSTPTG STAYAFSAGG 200
    PVVWPEVEAL LMVPISAHAL FAKPLVTSPD SVLAVEVLPH VPPGVLWCDG 250
    RRTVELPPGA RVEVRRGAVP VRLARLHHAS FTDRLVAKFA LPVSGWRGAP 300
    H 301
    Length:301
    Mass (Da):32,081
    Last modified:May 1, 2000 - v1
    Checksum:iFCB6F6B01766AFBA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939110 Genomic DNA. Translation: CAB52845.1.
    PIRiT36884.
    RefSeqiNP_626052.1. NC_003888.3.
    WP_011027973.1. NC_003888.3.

    Genome annotation databases

    EnsemblBacteriaiCAB52845; CAB52845; CAB52845.
    GeneIDi1097212.
    KEGGisco:SCO1781.
    PATRICi23733174. VBIStrCoe124346_1800.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL939110 Genomic DNA. Translation: CAB52845.1 .
    PIRi T36884.
    RefSeqi NP_626052.1. NC_003888.3.
    WP_011027973.1. NC_003888.3.

    3D structure databases

    ProteinModelPortali Q9S219.
    SMRi Q9S219. Positions 7-297.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 100226.SCO1781.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB52845 ; CAB52845 ; CAB52845 .
    GeneIDi 1097212.
    KEGGi sco:SCO1781.
    PATRICi 23733174. VBIStrCoe124346_1800.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000227223.
    KOi K00858.
    OMAi GVLWCDG.
    OrthoDBi EOG6PZXDR.
    PhylomeDBi Q9S219.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-471 / A3(2) / M145.

    Entry informationi

    Entry nameiNADK2_STRCO
    AccessioniPrimary (citable) accession number: Q9S219
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 4, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3