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Protein
Submitted name:

AdpA

Gene

adpA

Organism
Streptomyces griseus
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
AdpAImported
Gene namesi
Name:adpAImported
OrganismiStreptomyces griseusImported
Taxonomic identifieri1911 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesStreptomycineaeStreptomycetaceaeStreptomyces

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W6VX-ray2.95A215-340[»]
ProteinModelPortaliQ9S166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains HTH araC/xylS-type DNA-binding domain.SAAS annotation

Phylogenomic databases

OrthoDBiEOG651SXJ.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR025628. DJ-1_InhA.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
[Graphical view]
PfamiPF13278. DUF4066. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52317. SSF52317. 1 hit.
PROSITEiPS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9S166-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQDSAAATE AARKLTGRRR REVVAVLLFS GGPIFESSIP LSVFGIDRQD
60 70 80 90 100
AGVPRYRLLV CGGEEGPLRT TGGLELTAPY GLEAISRAGT VVVPAWRSIT
110 120 130 140 150
SPPPAEALDA LRRAHEEGAR IVGLCTGAFV LAAAGLLDGR PATTHWMYAP
160 170 180 190 200
TLAKRYPSVH VDPRELFVDD GDVLTSAGTA AGIDLCLHIV RTDHGTEAAG
210 220 230 240 250
ALARRLVVPP RRSGGQERYL DRSLPEEIGS DPLAEVVAWA LEHLHEQFDV
260 270 280 290 300
ETLAARAYMS RRTFDRRFRS LTGSAPLQWL ITQRVLQAQR LLETSDYSVD
310 320 330 340 350
EVAGRCGFRS PVALRGHFRR QLGSSPAAYR AAYRARRPQG VAESAATVVE
360 370 380 390 400
TMVPSQGPPS GRRGSTLSSA AVAVAASVGS GELSLPGPDA YVPGRPALPG

QRSAP
Length:405
Mass (Da):43,167
Last modified:April 30, 2000 - v1
Checksum:i0126EDE469631A92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023785 Genomic DNA. Translation: BAA86265.1.
PIRiT44488.

Genome annotation databases

PATRICi23756192. VBIStrGri32265_4849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB023785 Genomic DNA. Translation: BAA86265.1.
PIRiT44488.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3W6VX-ray2.95A215-340[»]
ProteinModelPortaliQ9S166.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

AraC-XylSSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

PATRICi23756192. VBIStrGri32265_4849.

Phylogenomic databases

OrthoDBiEOG651SXJ.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
3.40.50.880. 1 hit.
InterProiIPR029062. Class_I_gatase-like.
IPR025628. DJ-1_InhA.
IPR009057. Homeodomain-like.
IPR018060. HTH_AraC.
[Graphical view]
PfamiPF13278. DUF4066. 1 hit.
PF12833. HTH_18. 1 hit.
[Graphical view]
SMARTiSM00342. HTH_ARAC. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
SSF52317. SSF52317. 1 hit.
PROSITEiPS01124. HTH_ARAC_FAMILY_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The A-factor regulatory cascade leading to streptomycin biosynthesis in Streptomyces griseus: identification of a target gene of the A-factor receptor."
    Ohnishi Y., Kameyama S., Onaka H., Horinouchi S.
    Mol. Microbiol. 34:102-111(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: IFO13350Imported.
  2. "Complex structure of the DNA-binding domain of AdpA, the global transcription factor in Streptomyces griseus, and a target duplex DNA reveals the structural basis of its tolerant DNA sequence specificity."
    Yao M.D., Ohtsuka J., Nagata K., Miyazono K., Zhi Y., Ohnishi Y., Tanokura M.
    J. Biol. Chem. 288:31019-31029(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF 215-340.

Entry informationi

Entry nameiQ9S166_STRGR
AccessioniPrimary (citable) accession number: Q9S166
Entry historyi
Integrated into UniProtKB/TrEMBL: April 30, 2000
Last sequence update: April 30, 2000
Last modified: January 6, 2015
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.