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Q9S0X0

- Q9S0X0_CLOHI

UniProt

Q9S0X0 - Q9S0X0_CLOHI

Protein
Submitted name:

Class1 collagenase

Gene
N/A
Organism
Clostridium histolyticum
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1009 – 10091Calcium 1Imported
    Metal bindingi1011 – 10111Calcium 1Imported
    Metal bindingi1011 – 10111Calcium 2Imported
    Metal bindingi1013 – 10131Calcium 2Imported
    Metal bindingi1014 – 10141Calcium 2Imported
    Metal bindingi1032 – 10321Calcium 1; via carbonyl oxygenImported
    Metal bindingi1037 – 10371Calcium 1Imported
    Metal bindingi1037 – 10371Calcium 2Imported
    Metal bindingi1039 – 10391Calcium 2; via carbonyl oxygenImported
    Metal bindingi1040 – 10401Calcium 1Imported
    Metal bindingi1040 – 10401Calcium 2Imported

    GO - Molecular functioni

    1. serine-type endopeptidase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Ligandi

    CalciumImported, Metal-bindingImported

    Protein family/group databases

    MEROPSiM09.002.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Class1 collagenaseImported
    OrganismiClostridium histolyticumImported
    Taxonomic identifieri1498 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

    Subcellular locationi

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: InterPro

    Pathology & Biotechi

    Protein family/group databases

    Allergomei5989. Clo hi Collagenase.

    Interactioni

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NQDX-ray1.65A/B1003-1118[»]
    1NQJX-ray1.00A/B1003-1118[»]
    2O8OX-ray1.35A/B1003-1118[»]
    ProteinModelPortaliQ9S0X0.
    SMRiQ9S0X0. Positions 1005-1118.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9S0X0.

    Family & Domainsi

    Keywords - Domaini

    CollagenImported

    Family and domain databases

    Gene3Di2.60.40.670. 1 hit.
    InterProiIPR007280. Peptidase_C_arc/bac.
    IPR013661. Peptidase_M9_N_dom.
    IPR002169. Peptidase_M9A/M9B.
    IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    [Graphical view]
    PfamiPF01752. Peptidase_M9. 1 hit.
    PF08453. Peptidase_M9_N. 1 hit.
    PF00801. PKD. 1 hit.
    PF04151. PPC. 1 hit.
    [Graphical view]
    PRINTSiPR00931. MICOLLPTASE.
    SMARTiSM00089. PKD. 1 hit.
    [Graphical view]
    SUPFAMiSSF49299. SSF49299. 1 hit.
    PROSITEiPS50093. PKD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9S0X0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKNILKILM DSYSKESKIQ TVRRVTSVSL LAVYLTMNTS SLVLAKPIEN     50
    TNDTSIKNVE KLRNAPNEEN SKKVEDSKND KVEHVKNIEE AKVEQVAPEV 100
    KSKSTLRSAS IANTNSEKYD FEYLNGLSYT ELTNLIKNIK WNQINGLFNY 150
    STGSQKFFGD KNRVQAIINA LQESGRTYTA NDMKGIETFT EVLRAGFYLG 200
    YYNDGLSYLN DRNFQDKCIP AMIAIQKNPN FKLGTAVQDE VITSLGKLIG 250
    NASANAEVVN NCVPVLKQFR ENLNQYAPDY VKGTAVNELI KGIEFDFSGA 300
    AYEKDVKTMP WYGKIDPFIN ELKALGLYGN ITSATEWASD VGIYYLSKFG 350
    LYSTNRNDIV QSLEKAVDMY KYGKIAFVAM ERITWDYDGI GSNGKKVDHD 400
    KFLDDAEKHY LPKTYTFDNG TFIIRAGDKV SEEKIKRLYW ASREVKSQFH 450
    RVVGNDKALE VGNADDVLTM KIFNSPEEYK FNTNINGVST DNGGLYIEPR 500
    GTFYTYERTP QQSIFSLEEL FRHEYTHYLQ ARYLVDGLWG QGPFYEKNRL 550
    TWFDEGTAEF FAGSTRTSGV LPRKSILGYL AKDKVDHRYS LKKTLNSGYD 600
    DSDWMVYNYG FAVAHYLYEK DMPTFIKMNK AILNTDVKSY DEIIKKLSDD 650
    ANKNTDYQTH IQELADKYQG AGIPLVSDDY LKDHGYKKAS EVYSEISKAA 700
    SLTNTSVTAE KSQYFNTFTL RGTYTGETSK GEFKDWDEMS KKLDGTLESL 750
    AKNSWSGYKT LTAYFTNYRV TSDNKVQYDV VFHGVLTDNA DISNNKAPIA 800
    KVTGPSTGAV GRNIEFSGKD SKDEDGKIVS YDWDFVYGAT SRGKNSVHAY 850
    KKAGTYNVTL KVTDDKGATA TESFTIEIKN EDTTTPITKE MEPNDDIKEA 900
    NGPIVEGVTV KGDLNGSDDA DTFYFDVKED GDVTIELPYS GSSNFTWLVY 950
    KEGDDQNHIA SGIDKNNSKV GTFKSTKGRH YVFIYKHDSA SNISYSLNIK 1000
    GLGNEKLKEK ENNDSSDKAT VIPNFNTTMQ GSLLGDDSRD YYSFEVKEEG 1050
    EVNIELDKKD EFGVTWTLHP ESNINDRITY GQVDGNKVSN KVKLRPGKYY 1100
    LLVYKYSGSG NYELRVNK 1118
    Length:1,118
    Mass (Da):126,257
    Last modified:May 1, 2000 - v1
    Checksum:i869F9E4B8DFB3313
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026889 Genomic DNA. Translation: BAA86030.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB026889 Genomic DNA. Translation: BAA86030.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NQD X-ray 1.65 A/B 1003-1118 [» ]
    1NQJ X-ray 1.00 A/B 1003-1118 [» ]
    2O8O X-ray 1.35 A/B 1003-1118 [» ]
    ProteinModelPortali Q9S0X0.
    SMRi Q9S0X0. Positions 1005-1118.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9S0X0.

    Protein family/group databases

    Allergomei 5989. Clo hi Collagenase.
    MEROPSi M09.002.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q9S0X0.

    Family and domain databases

    Gene3Di 2.60.40.670. 1 hit.
    InterProi IPR007280. Peptidase_C_arc/bac.
    IPR013661. Peptidase_M9_N_dom.
    IPR002169. Peptidase_M9A/M9B.
    IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    [Graphical view ]
    Pfami PF01752. Peptidase_M9. 1 hit.
    PF08453. Peptidase_M9_N. 1 hit.
    PF00801. PKD. 1 hit.
    PF04151. PPC. 1 hit.
    [Graphical view ]
    PRINTSi PR00931. MICOLLPTASE.
    SMARTi SM00089. PKD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49299. SSF49299. 1 hit.
    PROSITEi PS50093. PKD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Class2 collagenase."
      Hosaka T., Yamato I.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: JCM1403Imported.
    2. "A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation."
      Wilson J.J., Matsushita O., Okabe A., Sakon J.
      EMBO J. 22:1743-1752(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) OF 1003-1118 IN COMPLEX WITH CALCIUM.
    3. "Induction of stable beta-sheet by Ca2+ in Clostridial collagen binding domain."
      Philominathan S.T.L., Wilson J.J., Matsushita O., Sakon J.
      Submitted (DEC-2006) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 1003-1118 IN COMPLEX WITH CALCIUM.

    Entry informationi

    Entry nameiQ9S0X0_CLOHI
    AccessioniPrimary (citable) accession number: Q9S0X0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3