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Q9S0X0

- Q9S0X0_CLOHI

UniProt

Q9S0X0 - Q9S0X0_CLOHI

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Protein
Submitted name: Class1 collagenase
Gene
N/A
Organism
Clostridium histolyticum
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi1009 – 10091Calcium 1Imported
Metal bindingi1011 – 10111Calcium 1Imported
Metal bindingi1011 – 10111Calcium 2Imported
Metal bindingi1013 – 10131Calcium 2Imported
Metal bindingi1014 – 10141Calcium 2Imported
Metal bindingi1032 – 10321Calcium 1; via carbonyl oxygenImported
Metal bindingi1037 – 10371Calcium 1Imported
Metal bindingi1037 – 10371Calcium 2Imported
Metal bindingi1039 – 10391Calcium 2; via carbonyl oxygenImported
Metal bindingi1040 – 10401Calcium 1Imported
Metal bindingi1040 – 10401Calcium 2Imported

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

CalciumImported, Metal-bindingImported

Protein family/group databases

MEROPSiM09.002.

Names & Taxonomyi

Protein namesi
Submitted name:
Class1 collagenaseImported
OrganismiClostridium histolyticumImported
Taxonomic identifieri1498 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium

Subcellular locationi

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei5989. Clo hi Collagenase.

Interactioni

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NQDX-ray1.65A/B1003-1118[»]
1NQJX-ray1.00A/B1003-1118[»]
2O8OX-ray1.35A/B1003-1118[»]
ProteinModelPortaliQ9S0X0.
SMRiQ9S0X0. Positions 1005-1118.

Miscellaneous databases

EvolutionaryTraceiQ9S0X0.

Family & Domainsi

Keywords - Domaini

CollagenImported

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR007280. Peptidase_C_arc/bac.
IPR013661. Peptidase_M9_N_dom.
IPR002169. Peptidase_M9A/M9B.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF01752. Peptidase_M9. 1 hit.
PF08453. Peptidase_M9_N. 1 hit.
PF00801. PKD. 1 hit.
PF04151. PPC. 1 hit.
[Graphical view]
PRINTSiPR00931. MICOLLPTASE.
SMARTiSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9S0X0-1 [UniParc]FASTAAdd to Basket

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MKKNILKILM DSYSKESKIQ TVRRVTSVSL LAVYLTMNTS SLVLAKPIEN     50
TNDTSIKNVE KLRNAPNEEN SKKVEDSKND KVEHVKNIEE AKVEQVAPEV 100
KSKSTLRSAS IANTNSEKYD FEYLNGLSYT ELTNLIKNIK WNQINGLFNY 150
STGSQKFFGD KNRVQAIINA LQESGRTYTA NDMKGIETFT EVLRAGFYLG 200
YYNDGLSYLN DRNFQDKCIP AMIAIQKNPN FKLGTAVQDE VITSLGKLIG 250
NASANAEVVN NCVPVLKQFR ENLNQYAPDY VKGTAVNELI KGIEFDFSGA 300
AYEKDVKTMP WYGKIDPFIN ELKALGLYGN ITSATEWASD VGIYYLSKFG 350
LYSTNRNDIV QSLEKAVDMY KYGKIAFVAM ERITWDYDGI GSNGKKVDHD 400
KFLDDAEKHY LPKTYTFDNG TFIIRAGDKV SEEKIKRLYW ASREVKSQFH 450
RVVGNDKALE VGNADDVLTM KIFNSPEEYK FNTNINGVST DNGGLYIEPR 500
GTFYTYERTP QQSIFSLEEL FRHEYTHYLQ ARYLVDGLWG QGPFYEKNRL 550
TWFDEGTAEF FAGSTRTSGV LPRKSILGYL AKDKVDHRYS LKKTLNSGYD 600
DSDWMVYNYG FAVAHYLYEK DMPTFIKMNK AILNTDVKSY DEIIKKLSDD 650
ANKNTDYQTH IQELADKYQG AGIPLVSDDY LKDHGYKKAS EVYSEISKAA 700
SLTNTSVTAE KSQYFNTFTL RGTYTGETSK GEFKDWDEMS KKLDGTLESL 750
AKNSWSGYKT LTAYFTNYRV TSDNKVQYDV VFHGVLTDNA DISNNKAPIA 800
KVTGPSTGAV GRNIEFSGKD SKDEDGKIVS YDWDFVYGAT SRGKNSVHAY 850
KKAGTYNVTL KVTDDKGATA TESFTIEIKN EDTTTPITKE MEPNDDIKEA 900
NGPIVEGVTV KGDLNGSDDA DTFYFDVKED GDVTIELPYS GSSNFTWLVY 950
KEGDDQNHIA SGIDKNNSKV GTFKSTKGRH YVFIYKHDSA SNISYSLNIK 1000
GLGNEKLKEK ENNDSSDKAT VIPNFNTTMQ GSLLGDDSRD YYSFEVKEEG 1050
EVNIELDKKD EFGVTWTLHP ESNINDRITY GQVDGNKVSN KVKLRPGKYY 1100
LLVYKYSGSG NYELRVNK 1118
Length:1,118
Mass (Da):126,257
Last modified:May 1, 2000 - v1
Checksum:i869F9E4B8DFB3313
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026889 Genomic DNA. Translation: BAA86030.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB026889 Genomic DNA. Translation: BAA86030.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NQD X-ray 1.65 A/B 1003-1118 [» ]
1NQJ X-ray 1.00 A/B 1003-1118 [» ]
2O8O X-ray 1.35 A/B 1003-1118 [» ]
ProteinModelPortali Q9S0X0.
SMRi Q9S0X0. Positions 1005-1118.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9S0X0.

Protein family/group databases

Allergomei 5989. Clo hi Collagenase.
MEROPSi M09.002.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei Q9S0X0.

Family and domain databases

Gene3Di 2.60.40.670. 1 hit.
InterProi IPR007280. Peptidase_C_arc/bac.
IPR013661. Peptidase_M9_N_dom.
IPR002169. Peptidase_M9A/M9B.
IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view ]
Pfami PF01752. Peptidase_M9. 1 hit.
PF08453. Peptidase_M9_N. 1 hit.
PF00801. PKD. 1 hit.
PF04151. PPC. 1 hit.
[Graphical view ]
PRINTSi PR00931. MICOLLPTASE.
SMARTi SM00089. PKD. 1 hit.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 1 hit.
PROSITEi PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Class2 collagenase."
    Hosaka T., Yamato I.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: JCM1403Imported.
  2. "A bacterial collagen-binding domain with novel calcium-binding motif controls domain orientation."
    Wilson J.J., Matsushita O., Okabe A., Sakon J.
    EMBO J. 22:1743-1752(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.00 ANGSTROMS) OF 1003-1118 IN COMPLEX WITH CALCIUM.
  3. "Induction of stable beta-sheet by Ca2+ in Clostridial collagen binding domain."
    Philominathan S.T.L., Wilson J.J., Matsushita O., Sakon J.
    Submitted (DEC-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 1003-1118 IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ9S0X0_CLOHI
AccessioniPrimary (citable) accession number: Q9S0X0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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