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Q9RZC5 (Q9RZC5_DEIRA) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in both the arginine and lysine biosynthetic pathways By similarity. HAMAP-Rule MF_01107

Catalytic activity

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate. HAMAP-Rule MF_01107

N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP-Rule MF_01107

Cofactor

Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP-Rule MF_01107

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP-Rule MF_01107

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (Thermus route): step 4/5. HAMAP-Rule MF_01107

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01107

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01107.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. HAMAP-Rule MF_01107

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region265 – 2684Pyridoxal phosphate binding By similarity HAMAP-Rule MF_01107

Sites

Binding site1571Pyridoxal phosphate; via carbonyl oxygen By similarity HAMAP-Rule MF_01107
Binding site1601N2-acetyl-L-ornithine By similarity HAMAP-Rule MF_01107
Binding site3211N2-acetyl-L-ornithine By similarity HAMAP-Rule MF_01107
Binding site3221Pyridoxal phosphate By similarity HAMAP-Rule MF_01107

Amino acid modifications

Modified residue2941N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01107

Sequences

Sequence LengthMass (Da)Tools
Q9RZC5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 32D698851A3B1D2D

FASTA45448,951
        10         20         30         40         50         60 
MTATQAKPRQ PDLKTSLPGP KTAEIMARDQ ATLSTSYMRP YPFVPDFGKG VWLTDVDGNT 

        70         80         90        100        110        120 
MLDFFAGIAV STTGHAHPHV VQAVQRQIEK FTHVCLTDYP QEITTSLAER LVKHVERPGE 

       130        140        150        160        170        180 
KWRVFFSNSG AEAVEAAVKL ARNHTGRQHI ISTMGSFHGR TYGAITLTGS KTKYKRGFGP 

       190        200        210        220        230        240 
LLPAVSHVPY PNPFRPPLGS TPENCGQAVI DHIESLFVGI LPADEVAAII VEPMQGEGGY 

       250        260        270        280        290        300 
IVPPADFLPG LRALCDKHGI MLIFDEVQAG MGRTGKMFSF QHFDVQPDII TSAKGIASGM 

       310        320        330        340        350        360 
PLGALLAKES VMTWPVGSHG STYGGNPVAA AASHATLDLL EGQVKHEGCG DSLMDNAAQV 

       370        380        390        400        410        420 
GDFILGELKG MQDEFPFIGD VRGRGLFIGI EFVKPDGSPD GALRDQASMM MFEKGLLNLD 

       430        440        450 
CGEAVIRISP PLILTREEAA TGLDIMRGVF QELK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001825 Genomic DNA. Translation: AAF12279.1.
PIRG75595.
RefSeqNP_285353.1. NC_001264.1.

3D structure databases

ProteinModelPortalQ9RZC5.
ModBaseSearch...

Protein-protein interaction databases

STRING243230.DR_A0029.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF12279; AAF12279; DR_A0029.
GeneID1798195.
KEGGdra:DR_A0029.
PATRIC21633094. VBIDeiRad64572_2917.

Phylogenomic databases

HOGENOMHOG000020206.
KOK00823.
OMAASKSAYR.
ProtClustDBPRK05769.

Enzyme and pathway databases

BioCycDRAD243230:GH46-2720-MONOMER.
UniPathwayUPA00033; UER00038.
UPA00068; UER00109.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_01107. ArgD_aminotrans_3.
InterProIPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR004636. Trfase_AcOrn/SuccOrn_fam.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
SUPFAMSSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ9RZC5_DEIRA
AccessionPrimary (citable) accession number: Q9RZC5
Entry history
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 29, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info