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Q9RZC5

- Q9RZC5_DEIRA

UniProt

Q9RZC5 - Q9RZC5_DEIRA

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Protein
Acetylornithine/acetyl-lysine aminotransferase
Gene
argD, lysJ, DR_A0029
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in both the arginine and lysine biosynthetic pathways By similarity.UniRule annotation

Catalytic activityi

N(2)-acetyl-L-lysine + 2-oxoglutarate = N-acetyl-L-aminoadipate semialdehyde + L-glutamate.UniRule annotation
N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.UniRule annotation

Cofactori

Binds 1 pyridoxal phosphate per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei157 – 1571Pyridoxal phosphate; via carbonyl oxygen By similarityUniRule annotation
Binding sitei160 – 1601N2-acetyl-L-ornithine By similarityUniRule annotation
Binding sitei321 – 3211N2-acetyl-L-ornithine By similarityUniRule annotation
Binding sitei322 – 3221Pyridoxal phosphate By similarityUniRule annotation

GO - Molecular functioni

  1. N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via aminoadipic acid Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesisUniRule annotation, Lysine biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2720-MONOMER.
UniPathwayiUPA00033; UER00038.
UPA00068; UER00109.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine/acetyl-lysine aminotransferaseUniRule annotation (EC:2.6.1.-UniRule annotation, EC:2.6.1.11UniRule annotation)
Short name:
ACOATUniRule annotation
Gene namesi
Name:argDUniRule annotation
Synonyms:lysJUniRule annotation
Ordered Locus Names:DR_A0029Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome II

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei294 – 2941N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_A0029.

Structurei

3D structure databases

ProteinModelPortaliQ9RZC5.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni265 – 2684Pyridoxal phosphate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000020206.
KOiK00823.
OMAiMCGFYAE.
OrthoDBiEOG6QVRHN.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPiMF_01107. ArgD_aminotrans_3.
InterProiIPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERiPTHR11986. PTHR11986. 1 hit.
PfamiPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFiPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RZC5-1 [UniParc]FASTAAdd to Basket

« Hide

MTATQAKPRQ PDLKTSLPGP KTAEIMARDQ ATLSTSYMRP YPFVPDFGKG    50
VWLTDVDGNT MLDFFAGIAV STTGHAHPHV VQAVQRQIEK FTHVCLTDYP 100
QEITTSLAER LVKHVERPGE KWRVFFSNSG AEAVEAAVKL ARNHTGRQHI 150
ISTMGSFHGR TYGAITLTGS KTKYKRGFGP LLPAVSHVPY PNPFRPPLGS 200
TPENCGQAVI DHIESLFVGI LPADEVAAII VEPMQGEGGY IVPPADFLPG 250
LRALCDKHGI MLIFDEVQAG MGRTGKMFSF QHFDVQPDII TSAKGIASGM 300
PLGALLAKES VMTWPVGSHG STYGGNPVAA AASHATLDLL EGQVKHEGCG 350
DSLMDNAAQV GDFILGELKG MQDEFPFIGD VRGRGLFIGI EFVKPDGSPD 400
GALRDQASMM MFEKGLLNLD CGEAVIRISP PLILTREEAA TGLDIMRGVF 450
QELK 454
Length:454
Mass (Da):48,951
Last modified:May 1, 2000 - v1
Checksum:i32D698851A3B1D2D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001825 Genomic DNA. Translation: AAF12279.1.
PIRiG75595.
RefSeqiNP_285353.1. NC_001264.1.
WP_010889289.1. NC_001264.1.

Genome annotation databases

EnsemblBacteriaiAAF12279; AAF12279; DR_A0029.
GeneIDi1798195.
KEGGidra:DR_A0029.
PATRICi21633094. VBIDeiRad64572_2917.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE001825 Genomic DNA. Translation: AAF12279.1 .
PIRi G75595.
RefSeqi NP_285353.1. NC_001264.1.
WP_010889289.1. NC_001264.1.

3D structure databases

ProteinModelPortali Q9RZC5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243230.DR_A0029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF12279 ; AAF12279 ; DR_A0029 .
GeneIDi 1798195.
KEGGi dra:DR_A0029.
PATRICi 21633094. VBIDeiRad64572_2917.

Phylogenomic databases

HOGENOMi HOG000020206.
KOi K00823.
OMAi MCGFYAE.
OrthoDBi EOG6QVRHN.

Enzyme and pathway databases

UniPathwayi UPA00033 ; UER00038 .
UPA00068 ; UER00109 .
BioCyci DRAD243230:GH46-2720-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPi MF_01107. ArgD_aminotrans_3.
InterProi IPR004636. AcOrn/SuccOrn_fam.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
PANTHERi PTHR11986. PTHR11986. 1 hit.
Pfami PF00202. Aminotran_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
PROSITEi PS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiQ9RZC5_DEIRA
AccessioniPrimary (citable) accession number: Q9RZC5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

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