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Q9RZ05 (HUTI_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Imidazolonepropionase
EC=3.5.2.7
Alternative name(s):
Imidazolone-5-propionate hydrolase
Gene names
Name:hutI
Ordered Locus Names:DR_A0148
OrganismDeinococcus radiodurans
Taxonomic identifier1299 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length399 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate + H2O = N-formimidoyl-L-glutamate + H+. HAMAP MF_00372

Cofactor

Binds 1 zinc or iron ion per subunit By similarity. HAMAP MF_00372

Pathway

Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. HAMAP MF_00372

Subcellular location

Cytoplasm Potential HAMAP MF_00372.

Sequence similarities

Belongs to the HutI family.

Ontologies

Keywords
   Biological processHistidine metabolism
   Cellular componentCytoplasm
   LigandIron
Metal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhistidine catabolic process to glutamate and formamide

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionimidazolonepropionase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 399399Imidazolonepropionase HAMAP MF_00372
PRO_0000160947

Sites

Metal binding741Zinc or iron By similarity
Metal binding761Zinc or iron By similarity
Metal binding2381Zinc or iron By similarity
Metal binding3121Zinc or iron By similarity
Binding site831Substrate By similarity
Binding site961Substrate By similarity
Binding site1461Substrate By similarity
Binding site1761Substrate By similarity
Binding site2411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RZ05 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 0D8A66747AB79D11

FASTA39941,572
        10         20         30         40         50         60 
MSETLYTGIS QLATPRPGPQ RGAAMGDLHI IEDAALLVRG GVIQWVGPRA AAPTATHVHD 

        70         80         90        100        110        120 
LGGRAVVPGL VDPHTHAVWA GDRLSDWEAK LQGATYEEIL ARGGGIRSTM RATAAADVAE 

       130        140        150        160        170        180 
LVALARPRLA SLRASGATTT EVKSGYGLDF DAELRMLRAV RELQAEFELR PTLLIHVPPQ 

       190        200        210        220        230        240 
EGRAEYVVGV CAELIPQVAR EGLAEALDVF CEKEAFSVEE TRTMFAAAQA HGLRVKLHAD 

       250        260        270        280        290        300 
QFHAIGGTEL ACEVGALSVD HLEASGAAQI AALAASETVA TILPGVTLHL GLPAAPGRQL 

       310        320        330        340        350        360 
IDSGAIVAIG TDLNPGSSPL FSTQLALALA VRLCLLTPAE ALSACTVNAA YALGLSDRGS 

       370        380        390 
LSAGQRADFL VLNGQDWREV AYTLGGNAVA EVYLAGAQL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE001825 Genomic DNA. Translation: AAF12215.1.
PIRG75610.
RefSeqNP_285472.1. NC_001264.1.

3D structure databases

ProteinModelPortalQ9RZ05.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1797984.
GenomeReviewsGene locus DR_A0148 in contig AE001825_GR.
KEGGdra:DR_A0148.
NMPDRfig|243230.1.peg.2962.
PATRIC21633332. VBIDeiRad64572_3035.
TIGRDR_A0148.

Phylogenomic databases

HOGENOMHBG686142.
OMAMNMACTL.
PhylomeDBQ9RZ05.
ProtClustDBPRK09356.

Enzyme and pathway databases

BioCycDRAD243230:DR_A0148-MONOMER.

Family and domain databases

HAMAPMF_00372. HutI.
[Tree]
InterProIPR013108. Amidohydro_3.
IPR005920. HutI.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01468.
PANTHERPTHR22642. PTHR22642. 1 hit.
PfamPF07969. Amidohydro_3. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR01224. HutI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHUTI_DEIRA
AccessionPrimary (citable) accession number: Q9RZ05
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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