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Protein

UvrABC system protein A

Gene

DR_A0188

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei104 – 1041ADPCombined sources
Binding sitei181 – 1811ADPCombined sources
Metal bindingi231 – 2311Zinc 1Combined sources
Metal bindingi234 – 2341Zinc 1Combined sources
Metal bindingi367 – 3671Zinc 1Combined sources
Metal bindingi370 – 3701Zinc 1Combined sources
Binding sitei450 – 4501ADP; via carbonyl oxygenCombined sources
Binding sitei455 – 4551ADPCombined sources
Binding sitei591 – 5911ADPCombined sources
Metal bindingi721 – 7211Zinc 2Combined sources
Metal bindingi724 – 7241Zinc 2Combined sources
Metal bindingi744 – 7441Zinc 2Combined sources
Metal bindingi747 – 7471Zinc 2Combined sources
Binding sitei806 – 8061ADPCombined sources
Binding sitei810 – 8101ADPCombined sources

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi124 – 1318ADPCombined sources
Nucleotide bindingi613 – 6186ADPCombined sources
Nucleotide bindingi648 – 6492ADPCombined sources

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Excision nucleaseSAAS annotation

Keywords - Biological processi

DNA damage, DNA excisionSAAS annotation, DNA repair

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, DNA-bindingSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2878-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein ASAAS annotation
Gene namesi
Ordered Locus Names:DR_A0188Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmSAAS annotation

PTM / Processingi

Proteomic databases

PRIDEiQ9RYW8.

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.SAAS annotation

Protein-protein interaction databases

DIPiDIP-48318N.
STRINGi243230.DR_A0188.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VF7X-ray2.30A/B/C81-922[»]
2VF8X-ray3.00A/B81-922[»]
ProteinModelPortaliQ9RYW8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RYW8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini583 – 912330ABC transporterInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.SAAS annotation
Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C5U. Bacteria.
COG0178. LUCA.
HOGENOMiHOG000050449.
InParanoidiQ9RYW8.
KOiK03701.
OMAiVMVELLF.
OrthoDBiEOG6QK4PS.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RYW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSSSMRRC RGALSLSFWI FLVLRSVLSR PVFGAAAGPA VQSARQCSAS
60 70 80 90 100
RGTGESDPPP FQPTLRLFPP SRRRRSYCRA MTPSRPSPDF PDGGFVQVRG
110 120 130 140 150
ARQHNLKDIS VKVPRDALVV FTGVSGSGKS SLAFGTLYAE AQRRYLESVS
160 170 180 190 200
PYARRLFNQA GVPDVDAIDG LPPAVALQQA RGTPTARSSV GSVTTLSNLL
210 220 230 240 250
RMLYSRAGDY PPGQGIVYAE GFSPNTPEGA CPECHGLGRV YTVTEDSMVP
260 270 280 290 300
DPSLTIRERA VAAWPQAWGG QNQRDILVTL GIDVDVPWRE LPEETRHWIL
310 320 330 340 350
FTDEQPVVPV YPGLTPAETQ RALKKKMEPS YMGTFSSARR HVLHTFANTE
360 370 380 390 400
SASMKKRVQG YMISEECPLC HGKRLRQEAL NVTFAGLDIT ELSRLPLARV
410 420 430 440 450
SELLRPYAEE REPGHAERVK NRPEQAIALQ RMAADLVKRL DVLLHLGLGY
460 470 480 490 500
LGLDRSTPTL SPGELQRLRL ATQLYSNLFG VVYVLDEPSA GLHPADTEAL
510 520 530 540 550
LSALENLKRG GNSLFVVEHD LDVIRRADWL VDVGPEAGEK GGEILYSGPP
560 570 580 590 600
EGLKHVPESQ TGQYLFADRH TEPHTPREPA GWLELNGVTR NNLDNLDVRF
610 620 630 640 650
PLGVMTSVTG VSGSGKSTLV SQALVDALAA HFGQPVNPDP EDDEDPADHT
660 670 680 690 700
AGSARLGGDL AQITRLVRVD QKPIGRTPRS NMATYTGLFD QVRKLFAATP
710 720 730 740 750
LAKKRGYNAG RFSFNVKGGR CEHCQGEGWV MVELLFLPSV YAPCPVCHGT
760 770 780 790 800
RYNAETLEVE YRGKNIADVL ALTVDEAHDF FADESAIFRA LDTLREVGLG
810 820 830 840 850
YLRLGQPATE LSGGEAQRIK LATELQRSGR GGTVYVLDEP TTGLHPADVE
860 870 880 890 900
RLQRQLVKLV DAGNTVIAVE HKMQVVAASD WVLDIGPGAG EDGGRLVAQG
910 920
TPAEVAQAAG SVTAPYLRAA LR
Length:922
Mass (Da):100,311
Last modified:May 1, 2000 - v1
Checksum:i3A94C2458A58906E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12187.1.
PIRiD75615.
RefSeqiNP_285511.1. NC_001264.1.
WP_010889447.1. NC_001264.1.

Genome annotation databases

EnsemblBacteriaiAAF12187; AAF12187; DR_A0188.
GeneIDi1798025.
KEGGidra:DR_A0188.
PATRICi21633416. VBIDeiRad64572_3077.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12187.1.
PIRiD75615.
RefSeqiNP_285511.1. NC_001264.1.
WP_010889447.1. NC_001264.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2VF7X-ray2.30A/B/C81-922[»]
2VF8X-ray3.00A/B81-922[»]
ProteinModelPortaliQ9RYW8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-48318N.
STRINGi243230.DR_A0188.

Proteomic databases

PRIDEiQ9RYW8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF12187; AAF12187; DR_A0188.
GeneIDi1798025.
KEGGidra:DR_A0188.
PATRICi21633416. VBIDeiRad64572_3077.

Phylogenomic databases

eggNOGiENOG4105C5U. Bacteria.
COG0178. LUCA.
HOGENOMiHOG000050449.
InParanoidiQ9RYW8.
KOiK03701.
OMAiVMVELLF.
OrthoDBiEOG6QK4PS.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2878-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9RYW8.

Family and domain databases

Gene3Di3.40.50.300. 5 hits.
InterProiIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.
  2. "Structural and mutational analyses of Deinococcus radiodurans UvrA2 provide insight into DNA binding and damage recognition by UvrAs."
    Timmins J., Gordon E., Caria S., Leonard G., Acajjaoui S., Kuo M.S., Monchois V., McSweeney S.
    Structure 17:547-558(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 81-922 IN COMPLEX WITH ADP AND ZINC.

Entry informationi

Entry nameiQ9RYW8_DEIRA
AccessioniPrimary (citable) accession number: Q9RYW8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 8, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.