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Protein

UvrABC system protein A

Gene

DR_A0188

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei104ADPCombined sources1
Binding sitei181ADPCombined sources1
Metal bindingi231Zinc 1Combined sources1
Metal bindingi234Zinc 1Combined sources1
Metal bindingi367Zinc 1Combined sources1
Metal bindingi370Zinc 1Combined sources1
Binding sitei450ADP; via carbonyl oxygenCombined sources1
Binding sitei455ADPCombined sources1
Binding sitei591ADPCombined sources1
Metal bindingi721Zinc 2Combined sources1
Metal bindingi724Zinc 2Combined sources1
Metal bindingi744Zinc 2Combined sources1
Metal bindingi747Zinc 2Combined sources1
Binding sitei806ADPCombined sources1
Binding sitei810ADPCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi124 – 131ADPCombined sources8
Nucleotide bindingi610 – 617ATPPROSITE-ProRule annotation8
Nucleotide bindingi611 – 618ADPCombined sources8
Nucleotide bindingi648 – 649ADPCombined sources2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, Excision nucleaseSAAS annotation
Biological processDNA damage, DNA excisionSAAS annotation, DNA repair
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2874-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein ASAAS annotation
Gene namesi
Ordered Locus Names:DR_A0188Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome II

Subcellular locationi

Q9RYW8:
  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrB during the search for lesions.SAAS annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
itself4EBI-15769194,EBI-15769194

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

DIPiDIP-48318N.
IntActiQ9RYW8. 1 interactor.
STRINGi243230.DR_A0188.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2VF7X-ray2.30A/B/C81-922[»]
2VF8X-ray3.00A/B81-922[»]
ProteinModelPortaliQ9RYW8.
SMRiQ9RYW8.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RYW8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini583 – 912ABC transporterInterPro annotationAdd BLAST330

Sequence similaritiesi

Belongs to the ABC transporter superfamily. UvrA family.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG4105C5U. Bacteria.
COG0178. LUCA.
HOGENOMiHOG000050449.
InParanoidiQ9RYW8.
KOiK03701.
OMAiGAWQGKN.
OrthoDBiPOG091H00GY.

Family and domain databases

InterProiView protein in InterPro
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
IPR004602. UvrA.
PfamiView protein in Pfam
PF00005. ABC_tran. 1 hit.
SUPFAMiSSF52540. SSF52540. 4 hits.
TIGRFAMsiTIGR00630. uvra. 1 hit.
PROSITEiView protein in PROSITE
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RYW8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVTSSSMRRC RGALSLSFWI FLVLRSVLSR PVFGAAAGPA VQSARQCSAS
60 70 80 90 100
RGTGESDPPP FQPTLRLFPP SRRRRSYCRA MTPSRPSPDF PDGGFVQVRG
110 120 130 140 150
ARQHNLKDIS VKVPRDALVV FTGVSGSGKS SLAFGTLYAE AQRRYLESVS
160 170 180 190 200
PYARRLFNQA GVPDVDAIDG LPPAVALQQA RGTPTARSSV GSVTTLSNLL
210 220 230 240 250
RMLYSRAGDY PPGQGIVYAE GFSPNTPEGA CPECHGLGRV YTVTEDSMVP
260 270 280 290 300
DPSLTIRERA VAAWPQAWGG QNQRDILVTL GIDVDVPWRE LPEETRHWIL
310 320 330 340 350
FTDEQPVVPV YPGLTPAETQ RALKKKMEPS YMGTFSSARR HVLHTFANTE
360 370 380 390 400
SASMKKRVQG YMISEECPLC HGKRLRQEAL NVTFAGLDIT ELSRLPLARV
410 420 430 440 450
SELLRPYAEE REPGHAERVK NRPEQAIALQ RMAADLVKRL DVLLHLGLGY
460 470 480 490 500
LGLDRSTPTL SPGELQRLRL ATQLYSNLFG VVYVLDEPSA GLHPADTEAL
510 520 530 540 550
LSALENLKRG GNSLFVVEHD LDVIRRADWL VDVGPEAGEK GGEILYSGPP
560 570 580 590 600
EGLKHVPESQ TGQYLFADRH TEPHTPREPA GWLELNGVTR NNLDNLDVRF
610 620 630 640 650
PLGVMTSVTG VSGSGKSTLV SQALVDALAA HFGQPVNPDP EDDEDPADHT
660 670 680 690 700
AGSARLGGDL AQITRLVRVD QKPIGRTPRS NMATYTGLFD QVRKLFAATP
710 720 730 740 750
LAKKRGYNAG RFSFNVKGGR CEHCQGEGWV MVELLFLPSV YAPCPVCHGT
760 770 780 790 800
RYNAETLEVE YRGKNIADVL ALTVDEAHDF FADESAIFRA LDTLREVGLG
810 820 830 840 850
YLRLGQPATE LSGGEAQRIK LATELQRSGR GGTVYVLDEP TTGLHPADVE
860 870 880 890 900
RLQRQLVKLV DAGNTVIAVE HKMQVVAASD WVLDIGPGAG EDGGRLVAQG
910 920
TPAEVAQAAG SVTAPYLRAA LR
Length:922
Mass (Da):100,311
Last modified:May 1, 2000 - v1
Checksum:i3A94C2458A58906E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12187.1.
PIRiD75615.
RefSeqiNP_285511.1. NC_001264.1.
WP_010889447.1. NZ_CP015082.1.

Genome annotation databases

EnsemblBacteriaiAAF12187; AAF12187; DR_A0188.
GeneIDi1798025.
KEGGidra:DR_A0188.
PATRICifig|243230.17.peg.3077.

Similar proteinsi

Entry informationi

Entry nameiQ9RYW8_DEIRA
AccessioniPrimary (citable) accession number: Q9RYW8
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: October 25, 2017
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported