NH(3)-dependent NAD(+) synthetase - Deinococcus radiodurans

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Reviewed, UniProtKB/Swiss-Prot Q9RYV5 (NADE_DEIRA)

Last modified November 3, 2009. Version 52. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
NH(3)-dependent NAD(+) synthetase
EC=6.3.1.5

Gene names

Name:	nadE
Ordered Locus Names:	DR_A0201

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + deamido-NAD⁺ + NH₃ = AMP + diphosphate + NAD⁺. HAMAP MF_00193
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193
Sequence similarities	Belongs to the NAD synthetase family.

Ontologies

Keywords
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP NAD+ synthase (glutamine-hydrolyzing) activity Inferred from electronic annotation. Source: InterPro NAD+ synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

287

NH(3)-dependent NAD(+) synthetase HAMAP MF_00193

PRO_0000152166

Regions

Nucleotide binding

8

ATP By similarity

Sites

Active site

1

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9RYV5-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 3258CD1549967F69
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287

31,077

        10         20         30         40         50         60 
MTPSPLPLSP LRSHIIRELH VQPDIDPGAE VERRVAFLCD YLQSTPTKGF VLGISGGQDS 

        70         80         90        100        110        120 
TLAGRLCQLA VERRRSQGHG ATFLAVRLPY GVQADEADAQ QALDFIQADR EVTVNIKEAA 

       130        140        150        160        170        180 
DASVAAAQAA LGSEVRDFVR GNVKARERMV AQYALAGQEN LLVVGTDHAA EALTGFYTKY 

       190        200        210        220        230        240 
GDGGVDLTPL SGLTKRQGAQ LLAHLGAPEG TWRKVPTADL EDDRPGLPDE VALGVTYAQI 

       250        260        270        280 
DAYLEGREVS DEAAARLERL FLNSRHKRAL PVTPFDGWWQ PGEQKQS

Cross-references

Sequence databases
	AE001825 Genomic DNA. Translation: AAF12179.1.
PIR	A75617.
RefSeq	NP_285524.1.
3D structure databases
HSSP	HSSP built from PDB template 1IH8 based on UniProtKB P08164.
ModBase	Search...
Genome annotation databases
GeneID	1797961.
GenomeReviews	Gene locus DR_A0201 in contig AE001825_GR.
KEGG	dra:DR_A0201.
NMPDR	fig\|243230.1.peg.3014.
TIGR	DR_A0201.
Phylogenomic databases
HOGENOM	Q9RYV5.
OMA	CELVHRR.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_A0201-MON.
BRENDA	6.3.1.5. 96172.
Family and domain databases
HAMAP	MF_00193. [Tree]
InterPro	IPR003694. NAD_synthase. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF02540. NAD_synthase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00552. nadE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADE_DEIRA

Accession

Primary (citable) accession number: Q9RYV5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents