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Protein

NAD(P)H dehydrogenase (quinone)

Gene

DR_A0214

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

It seems to function in response to environmental stress when various electron transfer chains are affected or when the environment is highly oxidizing. It reduces quinones to the hydroquinone state to prevent interaction of the semiquinone with O2 and production of superoxide (By similarity).By similarity

Catalytic activityi

NAD(P)H + a quinone = NAD(P)+ + a hydroquinone.

Cofactori

FMN1 PublicationNote: Binds 1 FMN per monomer.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateBy similarity1
Binding sitei142FMN1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 18FMN1 Publication5
Nucleotide bindingi86 – 88FMN1 Publication3
Nucleotide bindingi121 – 127FMN1 Publication7

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Flavoprotein, FMN, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2900-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H dehydrogenase (quinone) (EC:1.6.5.2)
Alternative name(s):
Flavoprotein WrbA
NAD(P)H:quinone oxidoreductase
Short name:
NQO
Gene namesi
Ordered Locus Names:DR_A0214
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00004223212 – 200NAD(P)H dehydrogenase (quinone)Add BLAST199

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi243230.DR_A0214.

Structurei

Secondary structure

1200
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 11Combined sources6
Beta strandi14 – 16Combined sources3
Helixi17 – 31Combined sources15
Beta strandi35 – 40Combined sources6
Helixi47 – 50Combined sources4
Helixi54 – 62Combined sources9
Turni63 – 65Combined sources3
Helixi71 – 76Combined sources6
Beta strandi78 – 87Combined sources10
Helixi93 – 100Combined sources8
Helixi103 – 107Combined sources5
Turni108 – 113Combined sources6
Beta strandi115 – 124Combined sources10
Helixi131 – 141Combined sources11
Turni142 – 144Combined sources3
Helixi155 – 159Combined sources5
Beta strandi164 – 166Combined sources3
Beta strandi168 – 170Combined sources3
Helixi178 – 199Combined sources22

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YDGX-ray2.00A/B/C/D/E/F/G/H2-199[»]
1YRHX-ray3.11A/B/C/D/E/F/G/H2-199[»]
ProteinModelPortaliQ9RYU4.
SMRiQ9RYU4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RYU4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 199Flavodoxin-likeAdd BLAST193

Sequence similaritiesi

Belongs to the WrbA family.Curated
Contains 1 flavodoxin-like domain.Curated

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
InParanoidiQ9RYU4.
KOiK03809.
OMAiQAGGLWM.
OrthoDBiPOG091H03V0.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RYU4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAPVKLAIV FYSSTGTGYA MAQEAAEAGR AAGAEVRLLK VRETAPQDVI
60 70 80 90 100
DGQDAWKANI EAMKDVPEAT PADLEWAEAI VFSSPTRFGG ATSQMRAFID
110 120 130 140 150
TLGGLWSSGK LANKTFSAMT SAQNVNGGQE TTLQTLYMTA MHWGAVLTPP
160 170 180 190 200
GYTDEVIFKS GGNPYGASVT ANGQPLLEND RASIRHQVRR QVELTAKLLG
Length:200
Mass (Da):21,298
Last modified:May 1, 2000 - v1
Checksum:iFD2FEA38E9775909
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12417.1.
PIRiG75573.
RefSeqiNP_285537.1. NC_001264.1.
WP_010889473.1. NZ_CP015082.1.

Genome annotation databases

EnsemblBacteriaiAAF12417; AAF12417; DR_A0214.
GeneIDi1798184.
KEGGidra:DR_A0214.
PATRICi21633468. VBIDeiRad64572_3103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12417.1.
PIRiG75573.
RefSeqiNP_285537.1. NC_001264.1.
WP_010889473.1. NZ_CP015082.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YDGX-ray2.00A/B/C/D/E/F/G/H2-199[»]
1YRHX-ray3.11A/B/C/D/E/F/G/H2-199[»]
ProteinModelPortaliQ9RYU4.
SMRiQ9RYU4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_A0214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF12417; AAF12417; DR_A0214.
GeneIDi1798184.
KEGGidra:DR_A0214.
PATRICi21633468. VBIDeiRad64572_3103.

Phylogenomic databases

eggNOGiENOG4105CS1. Bacteria.
COG0655. LUCA.
HOGENOMiHOG000030539.
InParanoidiQ9RYU4.
KOiK03809.
OMAiQAGGLWM.
OrthoDBiPOG091H03V0.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-2900-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9RYU4.

Family and domain databases

Gene3Di3.40.50.360. 1 hit.
HAMAPiMF_01017. NQOR. 1 hit.
InterProiIPR008254. Flavodoxin/NO_synth.
IPR029039. Flavoprotein-like_dom.
IPR010089. Flavoprotein_WrbA.
IPR005025. FMN_Rdtase-like.
[Graphical view]
PfamiPF03358. FMN_red. 1 hit.
[Graphical view]
SUPFAMiSSF52218. SSF52218. 1 hit.
TIGRFAMsiTIGR01755. flav_wrbA. 1 hit.
PROSITEiPS50902. FLAVODOXIN_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNQOR_DEIRA
AccessioniPrimary (citable) accession number: Q9RYU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2013
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.