Reviewed, UniProtKB/Swiss-Prot Q9RYG9 (ALDH_DEIRA)

Names and origin

Protein names

Recommended name:
    Aldehyde dehydrogenase
    EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	DR_A0348

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = an acid + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Aldehyde dehydrogenase		PRO_0000056447
Regions
	Nucleotide binding	228 – 234	7	NAD By similarity
Sites
	Active site	272	1	By similarity
	Active site	311	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RYG9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D8BB5DDF7D2DBBC0	FASTA	515	56,409
	10 20 30 40 50 60 MTVAEQQPQH QGYANPGTPG SVVTFKKRYD NFIGGQWVPP VKGQYFDNAS PVDGKVFTQA 70 80 90 100 110 120 ARSTAEDVEL ALDAAHRAAP AWGRTSVTER SNILLKIADR MEQNLEMLAV AETWDNGKPV 130 140 150 160 170 180 RETLAADLPL AIDHFRYFAG CIRAQEGGLS QIDDSTVAYH FHEPLGVVGQ IIPWNFPLLM 190 200 210 220 230 240 GVWKLAPALA AGNAVVLKPA EQTPASIMVL MELIADLLPE GVVNVVNGFG LEAGKPLASS 250 260 270 280 290 300 PRIAKIAFTG ETNTGRLIMG YAADNLIPVT LELGGKSPNI FFDDVMMEDD AFLDKAVEGM 310 320 330 340 350 360 VMFALNQGEV CTCPSRALIQ ESIYDRFMER AVQRVEAITM GHPLDPGTMI GAQASTEQLD 370 380 390 400 410 420 KILSYLDIGR AEGAEVLTGG ERGQREGLEE GFYVKPTIFK GHNKMRIFQE EIFGPVLAAA 430 440 450 460 470 480 TFKDEAEALE LANDTLYGLG AGLWTRDISR AYRMGRGIQA GRVWTNCYHV YPAHAAFGGY 490 500 510 KQSGIGRENH RMMLDHYQQT KNLLVSYSPN KMGFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[2]	"Isolation and characterization of pprA, a novel Deinococcus radiodurans gene involved in DNA repair." Narumi I., Du Z., Alatas Z., Kitayama S., Watanabe H. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258. Strain: KD8301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001825 Genomic DNA. Translation: AAF12436.1. AB003475 Genomic DNA. Translation: BAA21372.1.
PIR	H75589.
RefSeq	NP_285671.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1798223.
GenomeReviews	Gene locus DR_A0348 in contig AE001825_GR.
KEGG	dra:DR_A0348.
NMPDR	fig|243230.1.peg.3161.
TIGR	DR_A0348.
Phylogenomic databases
HOGENOM	HBG752218.
OMA	KSPNVYF.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_A0348-MONOMER.
BRENDA	1.2.1.3. 96172.
Family and domain databases
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHER	PTHR11699. Aldehyde_dehyd. 1 hit.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_DEIRA

Accession

Primary (citable) accession number: Q9RYG9
Secondary accession number(s): O32502

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	January 19, 2010
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)