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Q9RYG9

- ALDH_DEIRA

UniProt

Q9RYG9 - ALDH_DEIRA

Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei272 – 2721By similarity
    Active sitei311 – 3111By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi228 – 2347NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-3039-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase (EC:1.2.1.3)
    Gene namesi
    Name:aldA
    Ordered Locus Names:DR_A0348
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome II

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Aldehyde dehydrogenasePRO_0000056447Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243230.DR_A0348.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RYG9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00128.
    OMAiRIEQNIE.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RYG9-1 [UniParc]FASTAAdd to Basket

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    MTVAEQQPQH QGYANPGTPG SVVTFKKRYD NFIGGQWVPP VKGQYFDNAS    50
    PVDGKVFTQA ARSTAEDVEL ALDAAHRAAP AWGRTSVTER SNILLKIADR 100
    MEQNLEMLAV AETWDNGKPV RETLAADLPL AIDHFRYFAG CIRAQEGGLS 150
    QIDDSTVAYH FHEPLGVVGQ IIPWNFPLLM GVWKLAPALA AGNAVVLKPA 200
    EQTPASIMVL MELIADLLPE GVVNVVNGFG LEAGKPLASS PRIAKIAFTG 250
    ETNTGRLIMG YAADNLIPVT LELGGKSPNI FFDDVMMEDD AFLDKAVEGM 300
    VMFALNQGEV CTCPSRALIQ ESIYDRFMER AVQRVEAITM GHPLDPGTMI 350
    GAQASTEQLD KILSYLDIGR AEGAEVLTGG ERGQREGLEE GFYVKPTIFK 400
    GHNKMRIFQE EIFGPVLAAA TFKDEAEALE LANDTLYGLG AGLWTRDISR 450
    AYRMGRGIQA GRVWTNCYHV YPAHAAFGGY KQSGIGRENH RMMLDHYQQT 500
    KNLLVSYSPN KMGFF 515
    Length:515
    Mass (Da):56,409
    Last modified:May 1, 2000 - v1
    Checksum:iD8BB5DDF7D2DBBC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001825 Genomic DNA. Translation: AAF12436.1.
    AB003475 Genomic DNA. Translation: BAA21372.1.
    PIRiH75589.
    RefSeqiNP_285671.1. NC_001264.1.
    WP_010889607.1. NC_001264.1.

    Genome annotation databases

    EnsemblBacteriaiAAF12436; AAF12436; DR_A0348.
    GeneIDi1798223.
    KEGGidra:DR_A0348.
    PATRICi21633742. VBIDeiRad64572_3240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE001825 Genomic DNA. Translation: AAF12436.1 .
    AB003475 Genomic DNA. Translation: BAA21372.1 .
    PIRi H75589.
    RefSeqi NP_285671.1. NC_001264.1.
    WP_010889607.1. NC_001264.1.

    3D structure databases

    ProteinModelPortali Q9RYG9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_A0348.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF12436 ; AAF12436 ; DR_A0348 .
    GeneIDi 1798223.
    KEGGi dra:DR_A0348.
    PATRICi 21633742. VBIDeiRad64572_3240.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00128.
    OMAi RIEQNIE.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-3039-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    2. "Isolation and characterization of pprA, a novel Deinococcus radiodurans gene involved in DNA repair."
      Narumi I., Du Z., Alatas Z., Kitayama S., Watanabe H.
      Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258.
      Strain: KD8301.

    Entry informationi

    Entry nameiALDH_DEIRA
    AccessioniPrimary (citable) accession number: Q9RYG9
    Secondary accession number(s): O32502
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3