Q9RYG9 (ALDH_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aldehyde dehydrogenase
EC=1.2.1.3

Gene names

Name:	aldA
Ordered Locus Names:	DR_A0348

Organism

Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]

Taxonomic identifier

243230 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › Deinococcus radiodurans

Protein attributes

Sequence length	515 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	An aldehyde + NAD+ + H2O = a carboxylate + NADH.
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	aldehyde dehydrogenase (NAD) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 515	515	Aldehyde dehydrogenase		PRO_0000056447
Regions
	Nucleotide binding	228 – 234	7	NAD By similarity
Sites
	Active site	272	1	By similarity
	Active site	311	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RYG9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D8BB5DDF7D2DBBC0	FASTA	515	56,409
	10 20 30 40 50 60 MTVAEQQPQH QGYANPGTPG SVVTFKKRYD NFIGGQWVPP VKGQYFDNAS PVDGKVFTQA 70 80 90 100 110 120 ARSTAEDVEL ALDAAHRAAP AWGRTSVTER SNILLKIADR MEQNLEMLAV AETWDNGKPV 130 140 150 160 170 180 RETLAADLPL AIDHFRYFAG CIRAQEGGLS QIDDSTVAYH FHEPLGVVGQ IIPWNFPLLM 190 200 210 220 230 240 GVWKLAPALA AGNAVVLKPA EQTPASIMVL MELIADLLPE GVVNVVNGFG LEAGKPLASS 250 260 270 280 290 300 PRIAKIAFTG ETNTGRLIMG YAADNLIPVT LELGGKSPNI FFDDVMMEDD AFLDKAVEGM 310 320 330 340 350 360 VMFALNQGEV CTCPSRALIQ ESIYDRFMER AVQRVEAITM GHPLDPGTMI GAQASTEQLD 370 380 390 400 410 420 KILSYLDIGR AEGAEVLTGG ERGQREGLEE GFYVKPTIFK GHNKMRIFQE EIFGPVLAAA 430 440 450 460 470 480 TFKDEAEALE LANDTLYGLG AGLWTRDISR AYRMGRGIQA GRVWTNCYHV YPAHAAFGGY 490 500 510 KQSGIGRENH RMMLDHYQQT KNLLVSYSPN KMGFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[2]	"Isolation and characterization of pprA, a novel Deinococcus radiodurans gene involved in DNA repair." Narumi I., Du Z., Alatas Z., Kitayama S., Watanabe H. Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258. Strain: KD8301.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE001825 Genomic DNA. Translation: AAF12436.1. AB003475 Genomic DNA. Translation: BAA21372.1.
PIR	H75589.
RefSeq	NP_285671.1. NC_001264.1.
3D structure databases
ProteinModelPortal	Q9RYG9.
ModBase	Search...
Protein-protein interaction databases
STRING	243230.DR_A0348.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF12436; AAF12436; DR_A0348.
GeneID	1798223.
KEGG	dra:DR_A0348.
PATRIC	21633742. VBIDeiRad64572_3240.
Phylogenomic databases
eggNOG	COG1012.
HOGENOM	HOG000271505.
KO	K00128.
OMA	DKCLEGF.
Enzyme and pathway databases
BioCyc	DRAD243230:GH46-347-MONOMER.
Family and domain databases
Gene3D	3.40.309.10. 1 hit. 3.40.605.10. 1 hit.
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. [Graphical view]
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ALDH_DEIRA

Accession

Primary (citable) accession number: Q9RYG9
Secondary accession number(s): O32502

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program