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Protein

Aldehyde dehydrogenase

Gene

aldA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei272 – 2721By similarity
Active sitei311 – 3111By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi228 – 2347NADBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciDRAD243230:GH46-3039-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase (EC:1.2.1.3)
Gene namesi
Name:aldA
Ordered Locus Names:DR_A0348
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524 Componenti: Chromosome II

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Aldehyde dehydrogenasePRO_0000056447Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_A0348.

Structurei

3D structure databases

ProteinModelPortaliQ9RYG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9RYG9.
KOiK00138.
OMAiMIYANPG.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RYG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVAEQQPQH QGYANPGTPG SVVTFKKRYD NFIGGQWVPP VKGQYFDNAS
60 70 80 90 100
PVDGKVFTQA ARSTAEDVEL ALDAAHRAAP AWGRTSVTER SNILLKIADR
110 120 130 140 150
MEQNLEMLAV AETWDNGKPV RETLAADLPL AIDHFRYFAG CIRAQEGGLS
160 170 180 190 200
QIDDSTVAYH FHEPLGVVGQ IIPWNFPLLM GVWKLAPALA AGNAVVLKPA
210 220 230 240 250
EQTPASIMVL MELIADLLPE GVVNVVNGFG LEAGKPLASS PRIAKIAFTG
260 270 280 290 300
ETNTGRLIMG YAADNLIPVT LELGGKSPNI FFDDVMMEDD AFLDKAVEGM
310 320 330 340 350
VMFALNQGEV CTCPSRALIQ ESIYDRFMER AVQRVEAITM GHPLDPGTMI
360 370 380 390 400
GAQASTEQLD KILSYLDIGR AEGAEVLTGG ERGQREGLEE GFYVKPTIFK
410 420 430 440 450
GHNKMRIFQE EIFGPVLAAA TFKDEAEALE LANDTLYGLG AGLWTRDISR
460 470 480 490 500
AYRMGRGIQA GRVWTNCYHV YPAHAAFGGY KQSGIGRENH RMMLDHYQQT
510
KNLLVSYSPN KMGFF
Length:515
Mass (Da):56,409
Last modified:May 1, 2000 - v1
Checksum:iD8BB5DDF7D2DBBC0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12436.1.
AB003475 Genomic DNA. Translation: BAA21372.1.
PIRiH75589.
RefSeqiNP_285671.1. NC_001264.1.
WP_010889607.1. NC_001264.1.

Genome annotation databases

EnsemblBacteriaiAAF12436; AAF12436; DR_A0348.
GeneIDi1798223.
KEGGidra:DR_A0348.
PATRICi21633742. VBIDeiRad64572_3240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE001825 Genomic DNA. Translation: AAF12436.1.
AB003475 Genomic DNA. Translation: BAA21372.1.
PIRiH75589.
RefSeqiNP_285671.1. NC_001264.1.
WP_010889607.1. NC_001264.1.

3D structure databases

ProteinModelPortaliQ9RYG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_A0348.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF12436; AAF12436; DR_A0348.
GeneIDi1798223.
KEGGidra:DR_A0348.
PATRICi21633742. VBIDeiRad64572_3240.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9RYG9.
KOiK00138.
OMAiMIYANPG.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-3039-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. "Isolation and characterization of pprA, a novel Deinococcus radiodurans gene involved in DNA repair."
    Narumi I., Du Z., Alatas Z., Kitayama S., Watanabe H.
    Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258.
    Strain: KD8301.

Entry informationi

Entry nameiALDH_DEIRA
AccessioniPrimary (citable) accession number: Q9RYG9
Secondary accession number(s): O32502
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 27, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.