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Q9RYG9 (ALDH_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase

EC=1.2.1.3
Gene names
Name:aldA
Ordered Locus Names:DR_A0348
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functionaldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Aldehyde dehydrogenase
PRO_0000056447

Regions

Nucleotide binding228 – 2347NAD By similarity

Sites

Active site2721 By similarity
Active site3111 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RYG9 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: D8BB5DDF7D2DBBC0

FASTA51556,409
        10         20         30         40         50         60 
MTVAEQQPQH QGYANPGTPG SVVTFKKRYD NFIGGQWVPP VKGQYFDNAS PVDGKVFTQA 

        70         80         90        100        110        120 
ARSTAEDVEL ALDAAHRAAP AWGRTSVTER SNILLKIADR MEQNLEMLAV AETWDNGKPV 

       130        140        150        160        170        180 
RETLAADLPL AIDHFRYFAG CIRAQEGGLS QIDDSTVAYH FHEPLGVVGQ IIPWNFPLLM 

       190        200        210        220        230        240 
GVWKLAPALA AGNAVVLKPA EQTPASIMVL MELIADLLPE GVVNVVNGFG LEAGKPLASS 

       250        260        270        280        290        300 
PRIAKIAFTG ETNTGRLIMG YAADNLIPVT LELGGKSPNI FFDDVMMEDD AFLDKAVEGM 

       310        320        330        340        350        360 
VMFALNQGEV CTCPSRALIQ ESIYDRFMER AVQRVEAITM GHPLDPGTMI GAQASTEQLD 

       370        380        390        400        410        420 
KILSYLDIGR AEGAEVLTGG ERGQREGLEE GFYVKPTIFK GHNKMRIFQE EIFGPVLAAA 

       430        440        450        460        470        480 
TFKDEAEALE LANDTLYGLG AGLWTRDISR AYRMGRGIQA GRVWTNCYHV YPAHAAFGGY 

       490        500        510 
KQSGIGRENH RMMLDHYQQT KNLLVSYSPN KMGFF 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1."
White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. expand/collapse author list , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Science 286:1571-1577(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[2]"Isolation and characterization of pprA, a novel Deinococcus radiodurans gene involved in DNA repair."
Narumi I., Du Z., Alatas Z., Kitayama S., Watanabe H.
Submitted (APR-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-258.
Strain: KD8301.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE001825 Genomic DNA. Translation: AAF12436.1.
AB003475 Genomic DNA. Translation: BAA21372.1.
PIRH75589.
RefSeqNP_285671.1. NC_001264.1.

3D structure databases

ProteinModelPortalQ9RYG9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_A0348.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF12436; AAF12436; DR_A0348.
GeneID1798223.
KEGGdra:DR_A0348.
PATRIC21633742. VBIDeiRad64572_3240.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
KOK00128.
OMAYAGCIRA.
OrthoDBEOG6BS8QW.

Enzyme and pathway databases

BioCycDRAD243230:GH46-3039-MONOMER.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALDH_DEIRA
AccessionPrimary (citable) accession number: Q9RYG9
Secondary accession number(s): O32502
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 13, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families