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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotationSAAS annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. o-succinylbenzoate synthase (menC), o-succinylbenzoate synthase (menC)
  5. no protein annotated in this organism
  6. no protein annotated in this organism
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei168Proton donorUniRule annotation1
Metal bindingi168Magnesium 1Combined sources1
Metal bindingi168Magnesium 2Combined sources1
Metal bindingi195MagnesiumUniRule annotation1
Metal bindingi195Magnesium 1Combined sources1
Metal bindingi220MagnesiumUniRule annotation1
Metal bindingi220Magnesium 1Combined sources1
Metal bindingi220Magnesium 2Combined sources1
Metal bindingi245MagnesiumUniRule annotation1
Active sitei269Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationCombined sourcesSAAS annotation, Metal-bindingUniRule annotationCombined sourcesSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotationSAAS annotation (EC:4.2.1.113UniRule annotationSAAS annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:DR_0044Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0044.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R0MX-ray1.30A/B/C/D1-375[»]
1XPYX-ray2.30A/B/C/D1-375[»]
1XS2X-ray2.30A/B/C/D1-375[»]
2FKPX-ray2.00A/B/C/D1-375[»]
2GGGX-ray2.40A/B/C/D1-375[»]
2GGHX-ray2.20A/B/C/D1-375[»]
2GGIX-ray2.20A/B/C/D1-375[»]
2GGJX-ray2.50A/B/C/D1-375[»]
ProteinModelPortaliQ9RYA6.
SMRiQ9RYA6.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RYA6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini149 – 241MR_MLEInterPro annotationAdd BLAST93

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RVH. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000185900.
InParanoidiQ9RYA6.
KOiK02549.
OMAiDDIVDHR.
OrthoDBiPOG091H0IGH.

Family and domain databases

CDDicd03317. NAAAR. 1 hit.
Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01933. MenC_2. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
IPR010197. OSB_synthase_MenC_2.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01928. menC_lowGC/arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RYA6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHTGRMFKI EAAEIVVARL PLKFRFETSF GVQTHKVVPL LILHGEGVQG
60 70 80 90 100
VAEGTMEARP MYREETIAGA LDLLRGTFLP AILGQTFANP EAVADALGSY
110 120 130 140 150
RGNRMARAMV EMAAWDLWAR TLGVPLGTLL GGHKEQVEVG VSLGIQAGEQ
160 170 180 190 200
ATVDLVRKHV EQGYRRIKLK IKPGWDVQPV RATREAFPDI RLTVDANSAY
210 220 230 240 250
TLADAGRLRQ LDEYDLTYIE QPLAWDDLVD HAELARRIRT PLCLDESVAS
260 270 280 290 300
AADARKALAL GAGGVINLKV ARVGGHAESR RVHDVAQSFG APVWCGGMLE
310 320 330 340 350
SGIGRAHNIH LSTLPNFRLP GDTSSASRYW ERDLIQEPLE AVDGLMPVPQ
360 370
GPGTGVTLDR EFLATVTEAQ EEHRA
Length:375
Mass (Da):40,901
Last modified:May 1, 2000 - v1
Checksum:i62F68CFA9FEF3DA4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09631.1.
PIRiD75568.
RefSeqiNP_293770.1. NC_001263.1.
WP_010886692.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09631; AAF09631; DR_0044.
GeneIDi1799680.
KEGGidra:DR_0044.
PATRICi21627561. VBIDeiRad64572_0209.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09631.1.
PIRiD75568.
RefSeqiNP_293770.1. NC_001263.1.
WP_010886692.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1R0MX-ray1.30A/B/C/D1-375[»]
1XPYX-ray2.30A/B/C/D1-375[»]
1XS2X-ray2.30A/B/C/D1-375[»]
2FKPX-ray2.00A/B/C/D1-375[»]
2GGGX-ray2.40A/B/C/D1-375[»]
2GGHX-ray2.20A/B/C/D1-375[»]
2GGIX-ray2.20A/B/C/D1-375[»]
2GGJX-ray2.50A/B/C/D1-375[»]
ProteinModelPortaliQ9RYA6.
SMRiQ9RYA6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_0044.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF09631; AAF09631; DR_0044.
GeneIDi1799680.
KEGGidra:DR_0044.
PATRICi21627561. VBIDeiRad64572_0209.

Phylogenomic databases

eggNOGiENOG4107RVH. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000185900.
InParanoidiQ9RYA6.
KOiK02549.
OMAiDDIVDHR.
OrthoDBiPOG091H0IGH.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Miscellaneous databases

EvolutionaryTraceiQ9RYA6.

Family and domain databases

CDDicd03317. NAAAR. 1 hit.
Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01933. MenC_2. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
IPR010197. OSB_synthase_MenC_2.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01928. menC_lowGC/arch. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiQ9RYA6_DEIRA
AccessioniPrimary (citable) accession number: Q9RYA6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.