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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathway:iacetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciDRAD243230:GH46-78-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:DR_0073
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 702702Phosphate acetyltransferasePRO_0000405546Add
BLAST

Proteomic databases

PRIDEiQ9RY77.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi243230.DR_0073.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni375 – 702328Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
InParanoidiQ9RY77.
KOiK13788.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RY77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLFLAPTR NGVGLSSTAL GLARALERQS LKVAFLKPIA QTYEPRTDDS
60 70 80 90 100
VHFARAVAHL TTPDPIPLTR AEELLSQGGE EDLMEQVIAL AREAAGEGSD
110 120 130 140 150
VLIAEGLALN ERNVYAGTLN ARLARNLEAD TVLVSSLAGV TPAELADELE
160 170 180 190 200
IAAQGYRRSD GSGLAGFVLN FAPRELDFGS LMAELRSRSR VLASGELPLL
210 220 230 240 250
GVVSLDPALR QLRTLDVARA LDAEIINAGE AESRRVSSTV VTARSVPQMT
260 270 280 290 300
NLFTSGALIV TPADREDVIM AAALSHLSGT PLAGLMYTSG SAPEATIQQL
310 320 330 340 350
CEVALTSSLP VLRVPTNSFE TASRLVHLDF RVPHDDPRRM DRMLDYIADR
360 370 380 390 400
LDTVPLGARL RAPGVAGERR LPPSAFRYEL IQRARAANKR IVLPEGDEPR
410 420 430 440 450
TVKAAIRCTE KGIARCVLLA PPEKVRQVAQ GQGLELPEGL EIIDPETVRG
460 470 480 490 500
KYVAPMVELR KSKGLTEPQA EAQLEDSVVL GTMMLALGEV DGLVSGAVHT
510 520 530 540 550
TASTVRPALQ LIKTAPGSSL VSSVFFMLMP EQVLVYGDAA INPDPNAQEL
560 570 580 590 600
ADIAIQSADS AHAFGIPVRV AMLSYSTGES GSGEDVEKVK EATKLVRERR
610 620 630 640 650
PELLVDGPLQ YDAASVPSVG RSKAPDSPVA GRATVFIFPD LNTGNTTYKA
660 670 680 690 700
VQRSAGVVAV GPMLQGLRKP VNDLSRGALV DDIVYTIALT AIQATQSAAD

CG
Length:702
Mass (Da):74,665
Last modified:March 8, 2011 - v2
Checksum:i192F97376746F7D7
GO

Sequence cautioni

The sequence AAF09663.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09663.1. Different initiation.
PIRiG75563.
RefSeqiNP_293799.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09663; AAF09663; DR_0073.
GeneIDi1797525.
KEGGidra:DR_0073.
PATRICi21627619. VBIDeiRad64572_0236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09663.1. Different initiation.
PIRiG75563.
RefSeqiNP_293799.1. NC_001263.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_0073.

Proteomic databases

PRIDEiQ9RY77.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF09663; AAF09663; DR_0073.
GeneIDi1797525.
KEGGidra:DR_0073.
PATRICi21627619. VBIDeiRad64572_0236.

Phylogenomic databases

eggNOGiCOG0280.
HOGENOMiHOG000053797.
InParanoidiQ9RY77.
KOiK13788.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciDRAD243230:GH46-78-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiPTA_DEIRA
AccessioniPrimary (citable) accession number: Q9RY77
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 22, 2015
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.