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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase (ackA)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:DR_0073
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055461 – 702Phosphate acetyltransferaseAdd BLAST702

Proteomic databases

PRIDEiQ9RY77.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi243230.DR_0073.

Structurei

3D structure databases

SMRiQ9RY77.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 702Phosphate acetyltransferaseAdd BLAST328

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4108FWR. Bacteria.
COG0280. LUCA.
COG0857. LUCA.
HOGENOMiHOG000053797.
InParanoidiQ9RY77.
KOiK13788.
OrthoDBiPOG091H01MW.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
InterProiView protein in InterPro
IPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N-like.
PfamiView protein in Pfam
PF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RY77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLFLAPTR NGVGLSSTAL GLARALERQS LKVAFLKPIA QTYEPRTDDS
60 70 80 90 100
VHFARAVAHL TTPDPIPLTR AEELLSQGGE EDLMEQVIAL AREAAGEGSD
110 120 130 140 150
VLIAEGLALN ERNVYAGTLN ARLARNLEAD TVLVSSLAGV TPAELADELE
160 170 180 190 200
IAAQGYRRSD GSGLAGFVLN FAPRELDFGS LMAELRSRSR VLASGELPLL
210 220 230 240 250
GVVSLDPALR QLRTLDVARA LDAEIINAGE AESRRVSSTV VTARSVPQMT
260 270 280 290 300
NLFTSGALIV TPADREDVIM AAALSHLSGT PLAGLMYTSG SAPEATIQQL
310 320 330 340 350
CEVALTSSLP VLRVPTNSFE TASRLVHLDF RVPHDDPRRM DRMLDYIADR
360 370 380 390 400
LDTVPLGARL RAPGVAGERR LPPSAFRYEL IQRARAANKR IVLPEGDEPR
410 420 430 440 450
TVKAAIRCTE KGIARCVLLA PPEKVRQVAQ GQGLELPEGL EIIDPETVRG
460 470 480 490 500
KYVAPMVELR KSKGLTEPQA EAQLEDSVVL GTMMLALGEV DGLVSGAVHT
510 520 530 540 550
TASTVRPALQ LIKTAPGSSL VSSVFFMLMP EQVLVYGDAA INPDPNAQEL
560 570 580 590 600
ADIAIQSADS AHAFGIPVRV AMLSYSTGES GSGEDVEKVK EATKLVRERR
610 620 630 640 650
PELLVDGPLQ YDAASVPSVG RSKAPDSPVA GRATVFIFPD LNTGNTTYKA
660 670 680 690 700
VQRSAGVVAV GPMLQGLRKP VNDLSRGALV DDIVYTIALT AIQATQSAAD

CG
Length:702
Mass (Da):74,665
Last modified:March 8, 2011 - v2
Checksum:i192F97376746F7D7
GO

Sequence cautioni

The sequence AAF09663 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09663.1. Different initiation.
PIRiG75563.
RefSeqiNP_293799.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09663; AAF09663; DR_0073.
GeneIDi1797525.
KEGGidra:DR_0073.
PATRICifig|243230.17.peg.236.

Similar proteinsi

Entry informationi

Entry nameiPTA_DEIRA
AccessioniPrimary (citable) accession number: Q9RY77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: August 30, 2017
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families