Q9RY72 (ARGC2_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase 2
Short name=AGPR 2
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase 2
Short name=NAGSA dehydrogenase 2

Gene names

Name:	argC2
Ordered Locus Names:	DR_0078

Organism

Deinococcus radiodurans

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_01110
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_01110
Subcellular location	Cytoplasm Probable HAMAP MF_01110.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 2 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	N-acetyl-gamma-glutamyl-phosphate reductase 2 HAMAP MF_01110		PRO_0000112507
Sites
	Active site	117	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RY72 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 43D11A780EDC9883	FASTA	306	32,656
	10 20 30 40 50 60 MNKPKIFIDG EAGTTGLQIR ERLAGRSDLE LLSIDPVRRK DSAARAELLN AADVSILCLH 70 80 90 100 110 120 DDAAREAVSL TTNPASRLLD ASTAHRIHPD WVFGFPELSA EQPEKIRQAR YVANPGCYST 130 140 150 160 170 180 GAIALLAPLT GRGLLPADFP VHIQGYSGYT GGGRALVDAH EQGSAHPSKG AFISYGLTLE 190 200 210 220 230 240 HKHLPETMVY GGLTRKPVFT PNVGGWAQGM TVTVPLHLAE LGVSAEALHA ALKEHYAGQQ 250 260 270 280 290 300 YVKVFELADN PEILDPQTLN GTNNLELFVY PAADGERALL AARLDNLGKG ASGAAVQNLE LMLGLS

References

[1]

"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000513 Genomic DNA. Translation: AAF09671.1.
PIR	D75562.
RefSeq	NP_293804.1. NC_001263.1.
3D structure databases
ProteinModelPortal	Q9RY72.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1797410.
GenomeReviews	Gene locus DR_0078 in contig AE000513_GR.
KEGG	dra:DR_0078.
NMPDR	fig|243230.1.peg.263.
PATRIC	21627629. VBIDeiRad64572_0241.
TIGR	DR_0078.
Phylogenomic databases
HOGENOM	HBG294213.
OMA	PIFVPSV.
PhylomeDB	Q9RY72.
ProtClustDB	PRK11863.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_0078-MONOMER.
Family and domain databases
HAMAP	MF_01110. ArgC_type2. [Tree]
InterPro	IPR023013. AGPR_AS. IPR010136. AGPR_type-2. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01851. ArgC_other. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC2_DEIRA

Accession

Primary (citable) accession number: Q9RY72

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	May 1, 2000
Last modified:	January 25, 2012
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program