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Protein

Phosphoribosylaminoimidazole-succinocarboxamide synthase

Gene

purC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Phosphoribosylaminoimidazole-succinocarboxamide synthase (purC)
  2. Adenylosuccinate lyase (purB)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processPurine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00131.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthaseUniRule annotation (EC:6.3.2.6UniRule annotation)
Alternative name(s):
SAICAR synthetaseUniRule annotation
Gene namesi
Name:purCUniRule annotation
Ordered Locus Names:DR_0226
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001008241 – 237Phosphoribosylaminoimidazole-succinocarboxamide synthaseAdd BLAST237

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0226.

Structurei

3D structure databases

ProteinModelPortaliQ9RXT0.
SMRiQ9RXT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SAICAR synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8V. Bacteria.
COG0152. LUCA.
HOGENOMiHOG000082629.
InParanoidiQ9RXT0.
KOiK01923.
OMAiFNAQKRG.
OrthoDBiPOG091H02H7.

Family and domain databases

CDDicd01415. SAICAR_synt_PurC. 1 hit.
HAMAPiMF_00137. SAICAR_synth. 1 hit.
InterProiView protein in InterPro
IPR028923. SAICAR_synt/ADE2_N.
IPR033934. SAICAR_synt_PurC.
IPR001636. SAICAR_synth.
IPR018236. SAICAR_synthetase_CS.
PANTHERiPTHR43599:SF3. PTHR43599:SF3. 1 hit.
PfamiView protein in Pfam
PF01259. SAICAR_synt. 1 hit.
TIGRFAMsiTIGR00081. purC. 1 hit.
PROSITEiView protein in PROSITE
PS01057. SAICAR_SYNTHETASE_1. 1 hit.
PS01058. SAICAR_SYNTHETASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RXT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRGEMKYEG KAKRVYATEN PHEYVVEYKD DATAFNAQKR GEWAGKGATN
60 70 80 90 100
NAITAHLYPQ LEAAGIPTHF LEKLSDREQR VKAVTIVPVE VIVRNVAAGS
110 120 130 140 150
FSKRLGVEEG TPLPRPVVEY CYKSDALGDP LINTDTAVAL GWASEDDLKR
160 170 180 190 200
IRELALQIRD FLVPYFEKRG VRLIDFKLEF GKLPSGEIVL ADEISPDTCR
210 220 230
FWDAETNEKM DKDRFRRDLG GEAEAYAEML KRVTREV
Length:237
Mass (Da):26,815
Last modified:July 26, 2002 - v2
Checksum:i845CAFDA700ECAB7
GO

Sequence cautioni

The sequence AAF09811 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09811.1. Different initiation.
PIRiG75545.
RefSeqiNP_293950.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09811; AAF09811; DR_0226.
GeneIDi1798462.
KEGGidra:DR_0226.
PATRICifig|243230.17.peg.389.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPUR7_DEIRA
AccessioniPrimary (citable) accession number: Q9RXT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: July 26, 2002
Last modified: July 5, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families