Reviewed, UniProtKB/Swiss-Prot Q9RXR4 (SPEA_DEIRA)

Names and origin

Protein names

Recommended name:
    Biosynthetic arginine decarboxylase
      Short name=ADC
    EC=4.1.1.19

Gene names

Name:	speA
Ordered Locus Names:	DR_0243

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP MF_01417
Catalytic activity	L-arginine = agmatine + CO2. HAMAP MF_01417
Cofactor	Magnesium By similarity. HAMAP MF_01417 Pyridoxal phosphate By similarity. HAMAP MF_01417
Sequence similarities	Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Ontologies

Keywords
Biological process	Polyamine biosynthesis Spermidine biosynthesis
Ligand	Magnesium Metal-binding Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine catabolic process Inferred from electronic annotation. Source: InterPro spermidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	arginine decarboxylase activity Inferred from electronic annotation. Source: HAMAP magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 662	662	Biosynthetic arginine decarboxylase HAMAP MF_01417		PRO_0000149959
Regions
	Region	308 – 318	11	Substrate-binding Potential
Amino acid modifications
	Modified residue	126	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9RXR4-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 88DDA5636BD83E6A	FASTA	662	73,528
	10 20 30 40 50 60 MCPARLRTPR TASLPTHRRS AMTTANPLNT SFTSADAAEL YQVPNWSGGW FRVSDKGLME 70 80 90 100 110 120 ATPAPGLHAS LRAIVDEIVD RGESLPVILR FPQVLAGRVK HLNEAFQAAI NEYNYSGHYQ 130 140 150 160 170 180 GVFPIKVNQR RAVVETVAAA GYDYAHGLEA GSKAELALCL AQKMHPDALL CCNGFKDDGF 190 200 210 220 230 240 IKLALWGRTL GKNVVITIEK FTELDRILKQ AKALGVKPAV GVRFKLHARG SGQWEESGGD 250 260 270 280 290 300 QAKFGLNAYE LLRVVERLKE ENMLDSLVML HTHIGSQITD IRRVKVAVRE AAQTYAGLIA 310 320 330 340 350 360 AGADLKYLNV GGGLGVDYDG SKTTFYASMN YTVKEYAADI VYTVQEVCKA REVPEPVIVS 370 380 390 400 410 420 ESGRALTAHH AVLILPVVDV TGPTRNLEDQ ELTVPGEDSH QIVRDMYETL ENISMRNYRE 430 440 450 460 470 480 SYNDAVGDKQ TLHNLFDLGY VTLEDRARGE ALFNAILRKI AKLIQGEKYV PDELEDLQKV 490 500 510 520 530 540 LADKFICNFS LFQSLPDNWA IGALFPIVPL DRLNEQPTRQ ATLVDITCDS DGKVEKFIDL 550 560 570 580 590 600 RDVKATLPLH EPGDRPYYLG AFLMGAYQDV LGSAHNLFGK VSEAHVTVRP GGRFNIDLFV 610 620 630 640 650 660 RGQKARRMIE SMGYEEPMLR DAIEDQADAA IGRGTLTQEQ EHELLEDYGE ELLGYTYLEY ES

References

[1]

"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000513 Genomic DNA. Translation: AAF09826.1.
PIR	B75544.
RefSeq	NP_293967.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1799241.
GenomeReviews	Gene locus DR_0243 in contig AE000513_GR.
KEGG	dra:DR_0243.
NMPDR	fig|243230.1.peg.426.
TIGR	DR_0243.
Phylogenomic databases
HOGENOM	HBG321436.
OMA	LICNGYK.
Enzyme and pathway databases
BioCyc	DRAD243230:DR_0243-MONOMER.
BRENDA	4.1.1.19. 96172.
Family and domain databases
HAMAP	MF_01417. SpeA. [Tree]
InterPro	IPR002985. Arg_decrbxlase. IPR000183. De-COase2. [Graphical view]
PANTHER	PTHR11482:SF3. Arg_decrbxlase. 1 hit.
Pfam	PF02784. Orn_Arg_deC_N. 1 hit. PF00278. Orn_DAP_Arg_deC. 1 hit. [Graphical view]
PIRSF	PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTS	PR01180. ARGDCRBXLASE. PR01179. ODADCRBXLASE.
TIGRFAMs	TIGR01273. speA. 1 hit.
PROSITE	PS00878. ODR_DC_2_1. 1 hit. PS00879. ODR_DC_2_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SPEA_DEIRA

Accession

Primary (citable) accession number: Q9RXR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2004
Last sequence update:	May 1, 2000
Last modified:	February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)