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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N5-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143S-adenosyl-L-methionineUniRule annotation1
Binding sitei184S-adenosyl-L-methionineUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Ordered Locus Names:DR_0245
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004145171 – 278Release factor glutamine methyltransferaseAdd BLAST278

Proteomic databases

PRIDEiQ9RXR2

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0245

Structurei

3D structure databases

ProteinModelPortaliQ9RXR2
SMRiQ9RXR2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 124S-adenosyl-L-methionine bindingUniRule annotation5
Regioni184 – 187Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY Bacteria
COG2890 LUCA
HOGENOMiHOG000076276
InParanoidiQ9RXR2
KOiK02493
OMAiMLVSNPP
OrthoDBiPOG091H02CJ

Family and domain databases

HAMAPiMF_02126 RF_methyltr_PrmC, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR004556 Modification_methylase_HemK
IPR019874 Release_fac_Glu-N5_MeTfrase
IPR029063 SAM-dependent_MTases
IPR007848 Small_mtfrase_dom
PfamiView protein in Pfam
PF05175 MTS, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
TIGRFAMsiTIGR00536 hemK_fam, 1 hit
TIGR03534 RF_mod_PrmC, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RXR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLRDLLTQA TARLTRAGVP SPEVDARLLL EHVLGLNRTA FLLRGGEEIG
60 70 80 90 100
PDAEARAWDS IERRAARVPL QHLTGEVEWG GVRLTSDARA LVPRPETEWL
110 120 130 140 150
LHLALEELRR VEKPRVLDVG TGTGALALGL KAAIPQAEVT ATDLSPEALS
160 170 180 190 200
LARENAALSG LDVKFVEGSL LAGLSGPFNL IVSNPPYLPT ADRATADPEV
210 220 230 240 250
RHDPDLALYA GEDGLDVARP LVAEAAAALV PGGALLLELD PRNAPTLAAE
260 270
LRTAGWQAEV RPDLTGRERF VRARRAGG
Length:278
Mass (Da):29,677
Last modified:May 1, 2000 - v1
Checksum:iF14E0E9447F68E30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF09827.1
PIRiD75544
RefSeqiNP_293969.1, NC_001263.1
WP_010886891.1, NZ_CP015081.1

Genome annotation databases

EnsemblBacteriaiAAF09827; AAF09827; DR_0245
GeneIDi1799150
KEGGidra:DR_0245
PATRICifig|243230.17.peg.409

Similar proteinsi

Entry informationi

Entry nameiPRMC_DEIRA
AccessioniPrimary (citable) accession number: Q9RXR2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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