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Protein

Release factor glutamine methyltransferase

Gene

prmC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + [peptide chain release factor 1 or 2]-L-glutamine = S-adenosyl-L-homocysteine + [peptide chain release factor 1 or 2]-N(5)-methyl-L-glutamine.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431S-adenosyl-L-methionineUniRule annotation
Binding sitei184 – 1841S-adenosyl-L-methionineUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciDRAD243230:GH46-251-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Release factor glutamine methyltransferaseUniRule annotation (EC:2.1.1.297UniRule annotation)
Short name:
RF MTaseUniRule annotation
Alternative name(s):
N5-glutamine methyltransferase PrmCUniRule annotation
Protein-(glutamine-N5) MTase PrmCUniRule annotation
Protein-glutamine N-methyltransferase PrmCUniRule annotation
Gene namesi
Name:prmCUniRule annotation
Ordered Locus Names:DR_0245
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Release factor glutamine methyltransferasePRO_0000414517Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0245.

Structurei

3D structure databases

ProteinModelPortaliQ9RXR2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni120 – 1245S-adenosyl-L-methionine bindingUniRule annotation
Regioni184 – 1874Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076276.
InParanoidiQ9RXR2.
KOiK02493.
OMAiILGAWEF.
OrthoDBiEOG68Q0SZ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RXR2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLRDLLTQA TARLTRAGVP SPEVDARLLL EHVLGLNRTA FLLRGGEEIG
60 70 80 90 100
PDAEARAWDS IERRAARVPL QHLTGEVEWG GVRLTSDARA LVPRPETEWL
110 120 130 140 150
LHLALEELRR VEKPRVLDVG TGTGALALGL KAAIPQAEVT ATDLSPEALS
160 170 180 190 200
LARENAALSG LDVKFVEGSL LAGLSGPFNL IVSNPPYLPT ADRATADPEV
210 220 230 240 250
RHDPDLALYA GEDGLDVARP LVAEAAAALV PGGALLLELD PRNAPTLAAE
260 270
LRTAGWQAEV RPDLTGRERF VRARRAGG
Length:278
Mass (Da):29,677
Last modified:May 1, 2000 - v1
Checksum:iF14E0E9447F68E30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09827.1.
PIRiD75544.
RefSeqiNP_293969.1. NC_001263.1.
WP_010886891.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09827; AAF09827; DR_0245.
GeneIDi1799150.
KEGGidra:DR_0245.
PATRICi21627973. VBIDeiRad64572_0409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF09827.1.
PIRiD75544.
RefSeqiNP_293969.1. NC_001263.1.
WP_010886891.1. NC_001263.1.

3D structure databases

ProteinModelPortaliQ9RXR2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_0245.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF09827; AAF09827; DR_0245.
GeneIDi1799150.
KEGGidra:DR_0245.
PATRICi21627973. VBIDeiRad64572_0409.

Phylogenomic databases

eggNOGiENOG4105EQY. Bacteria.
COG2890. LUCA.
HOGENOMiHOG000076276.
InParanoidiQ9RXR2.
KOiK02493.
OMAiILGAWEF.
OrthoDBiEOG68Q0SZ.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-251-MONOMER.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_02126. RF_methyltr_PrmC.
InterProiIPR002052. DNA_methylase_N6_adenine_CS.
IPR004556. Modification_methylase_HemK.
IPR019874. Release_fac_Glu-N5_MeTfrase.
IPR029063. SAM-dependent_MTases.
IPR007848. Small_mtfrase_dom.
[Graphical view]
PfamiPF05175. MTS. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00536. hemK_fam. 1 hit.
TIGR03534. RF_mod_PrmC. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiPRMC_DEIRA
AccessioniPrimary (citable) accession number: Q9RXR2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: May 1, 2000
Last modified: November 11, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.