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Q9RXK2 (RL3_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L3
Gene names
Name:rplC
Ordered Locus Names:DR_0311
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length211 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit By similarity. HAMAP-Rule MF_01325_B

Subunit structure

Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. Also contacts proteins L13 and L17. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8

Sequence similarities

Belongs to the ribosomal protein L3P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21121150S ribosomal protein L3 HAMAP-Rule MF_01325_B
PRO_0000077097

Secondary structure

........................................... 211
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9RXK2 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 04D0EE53A6276CE4

FASTA21122,437
        10         20         30         40         50         60 
MKGILGTKIG MTQIWKNDRA IPVTVVLAGP CPIVQRKTAQ TDGYEAVQIG YAPKAERKVN 

        70         80         90        100        110        120 
KPMQGHFAKA GVAPTRILRE FRGFAPDGDS VNVDIFAEGE KIDATGTSKG KGTQGVMKRW 

       130        140        150        160        170        180 
NFAGGPASHG SKKWHRRPGS IGQRKTPGRV YKGKRMAGHM GMERVTVQNL EVVEIRAGEN 

       190        200        210 
LILVKGAIPG ANGGLVVLRS AAKASAAKGG K 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1."
White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. expand/collapse author list , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Science 286:1571-1577(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[2]"High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, PROTEIN SEQUENCE OF 1-5.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[3]"Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[4]"Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[5]"Structural basis for the antibiotic activity of ketolides and azalides."
Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[6]"Structural insight into the role of the ribosomal tunnel in cellular regulation."
Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[7]"Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[8]"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF09892.1.
PIRG75533.
RefSeqNP_294034.1. NC_001263.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKWX-ray3.10B1-211[»]
1NWXX-ray3.50B1-211[»]
1NWYX-ray3.30B1-211[»]
1PNUX-ray8.70B1-205[»]
1PNYX-ray9.50B1-205[»]
1SM1X-ray3.42B1-211[»]
1XBPX-ray3.50B1-211[»]
2OGMX-ray3.50B1-211[»]
2OGNX-ray3.56B1-211[»]
2OGOX-ray3.66B1-211[»]
2ZJPX-ray3.70B1-211[»]
2ZJQX-ray3.30B1-211[»]
2ZJRX-ray2.91B1-211[»]
3CF5X-ray3.30B1-211[»]
3DLLX-ray3.50B1-211[»]
3PIOX-ray3.25B1-211[»]
3PIPX-ray3.45B1-211[»]
4IO9X-ray3.20B1-211[»]
4IOAX-ray3.20B1-211[»]
4IOCX-ray3.60B1-211[»]
ProteinModelPortalQ9RXK2.
SMRQ9RXK2. Positions 1-205.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0311.

Proteomic databases

PRIDEQ9RXK2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF09892; AAF09892; DR_0311.
GeneID1799285.
KEGGdra:DR_0311.
PATRIC21628120. VBIDeiRad64572_0477.

Phylogenomic databases

eggNOGCOG0087.
HOGENOMHOG000100368.
KOK02906.
OMAKGMRMAG.
OrthoDBEOG6WDSMH.
ProtClustDBPRK00001.

Enzyme and pathway databases

BioCycDRAD243230:GH46-321-MONOMER.

Family and domain databases

HAMAPMF_01325_B. Ribosomal_L3_B.
InterProIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERPTHR11229. PTHR11229. 1 hit.
PfamPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMSSF50447. SSF50447. 1 hit.
TIGRFAMsTIGR03625. L3_bact. 1 hit.
PROSITEPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9RXK2.

Entry information

Entry nameRL3_DEIRA
AccessionPrimary (citable) accession number: Q9RXK2
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references