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Q9RXK2

- RL3_DEIRA

UniProt

Q9RXK2 - RL3_DEIRA

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Protein
50S ribosomal protein L3
Gene
rplC, DR_0311
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-321-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L3
Gene namesi
Name:rplC
Ordered Locus Names:DR_0311
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21121150S ribosomal protein L3UniRule annotation
PRO_0000077097Add
BLAST

Proteomic databases

PRIDEiQ9RXK2.

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. Also contacts proteins L13 and L17.7 Publications

Protein-protein interaction databases

STRINGi243230.DR_0311.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi3 – 1614
Beta strandi19 – 279
Beta strandi31 – 377
Turni39 – 413
Beta strandi42 – 443
Beta strandi46 – 505
Helixi56 – 583
Helixi61 – 688
Turni69 – 713
Beta strandi78 – 814
Beta strandi87 – 904
Turni93 – 953
Beta strandi101 – 1077
Beta strandi110 – 1145
Helixi116 – 1205
Beta strandi127 – 1304
Beta strandi132 – 1354
Beta strandi144 – 1474
Beta strandi158 – 1614
Beta strandi164 – 17613
Turni177 – 1804
Beta strandi181 – 1866
Beta strandi195 – 2006

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1NKWX-ray3.10B1-211[»]
1NWXX-ray3.50B1-211[»]
1NWYX-ray3.30B1-211[»]
1PNUX-ray8.70B1-205[»]
1PNYX-ray9.50B1-205[»]
1SM1X-ray3.42B1-211[»]
1VOWX-ray11.50E1-205[»]
1VOYX-ray11.50E1-205[»]
1VP0X-ray11.50E1-205[»]
1XBPX-ray3.50B1-211[»]
2OGMX-ray3.50B1-211[»]
2OGNX-ray3.56B1-211[»]
2OGOX-ray3.66B1-211[»]
2ZJPX-ray3.70B1-211[»]
2ZJQX-ray3.30B1-211[»]
2ZJRX-ray2.91B1-211[»]
3CF5X-ray3.30B1-211[»]
3DLLX-ray3.50B1-211[»]
3PIOX-ray3.25B1-211[»]
3PIPX-ray3.45B1-211[»]
4IO9X-ray3.20B1-211[»]
4IOAX-ray3.20B1-211[»]
4IOCX-ray3.60B1-211[»]
ProteinModelPortaliQ9RXK2.
SMRiQ9RXK2. Positions 1-205.

Miscellaneous databases

EvolutionaryTraceiQ9RXK2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0087.
HOGENOMiHOG000100368.
KOiK02906.
OMAiSMQDATH.
OrthoDBiEOG6WDSMH.

Family and domain databases

HAMAPiMF_01325_B. Ribosomal_L3_B.
InterProiIPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view]
PANTHERiPTHR11229. PTHR11229. 1 hit.
PfamiPF00297. Ribosomal_L3. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
TIGRFAMsiTIGR03625. L3_bact. 1 hit.
PROSITEiPS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RXK2-1 [UniParc]FASTAAdd to Basket

« Hide

MKGILGTKIG MTQIWKNDRA IPVTVVLAGP CPIVQRKTAQ TDGYEAVQIG    50
YAPKAERKVN KPMQGHFAKA GVAPTRILRE FRGFAPDGDS VNVDIFAEGE 100
KIDATGTSKG KGTQGVMKRW NFAGGPASHG SKKWHRRPGS IGQRKTPGRV 150
YKGKRMAGHM GMERVTVQNL EVVEIRAGEN LILVKGAIPG ANGGLVVLRS 200
AAKASAAKGG K 211
Length:211
Mass (Da):22,437
Last modified:May 1, 2000 - v1
Checksum:i04D0EE53A6276CE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF09892.1.
PIRiG75533.
RefSeqiNP_294034.1. NC_001263.1.
WP_010886956.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09892; AAF09892; DR_0311.
GeneIDi1799285.
KEGGidra:DR_0311.
PATRICi21628120. VBIDeiRad64572_0477.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF09892.1 .
PIRi G75533.
RefSeqi NP_294034.1. NC_001263.1.
WP_010886956.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1NKW X-ray 3.10 B 1-211 [» ]
1NWX X-ray 3.50 B 1-211 [» ]
1NWY X-ray 3.30 B 1-211 [» ]
1PNU X-ray 8.70 B 1-205 [» ]
1PNY X-ray 9.50 B 1-205 [» ]
1SM1 X-ray 3.42 B 1-211 [» ]
1VOW X-ray 11.50 E 1-205 [» ]
1VOY X-ray 11.50 E 1-205 [» ]
1VP0 X-ray 11.50 E 1-205 [» ]
1XBP X-ray 3.50 B 1-211 [» ]
2OGM X-ray 3.50 B 1-211 [» ]
2OGN X-ray 3.56 B 1-211 [» ]
2OGO X-ray 3.66 B 1-211 [» ]
2ZJP X-ray 3.70 B 1-211 [» ]
2ZJQ X-ray 3.30 B 1-211 [» ]
2ZJR X-ray 2.91 B 1-211 [» ]
3CF5 X-ray 3.30 B 1-211 [» ]
3DLL X-ray 3.50 B 1-211 [» ]
3PIO X-ray 3.25 B 1-211 [» ]
3PIP X-ray 3.45 B 1-211 [» ]
4IO9 X-ray 3.20 B 1-211 [» ]
4IOA X-ray 3.20 B 1-211 [» ]
4IOC X-ray 3.60 B 1-211 [» ]
ProteinModelPortali Q9RXK2.
SMRi Q9RXK2. Positions 1-205.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243230.DR_0311.

Proteomic databases

PRIDEi Q9RXK2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF09892 ; AAF09892 ; DR_0311 .
GeneIDi 1799285.
KEGGi dra:DR_0311.
PATRICi 21628120. VBIDeiRad64572_0477.

Phylogenomic databases

eggNOGi COG0087.
HOGENOMi HOG000100368.
KOi K02906.
OMAi SMQDATH.
OrthoDBi EOG6WDSMH.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-321-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9RXK2.

Family and domain databases

HAMAPi MF_01325_B. Ribosomal_L3_B.
InterProi IPR000597. Ribosomal_L3.
IPR019927. Ribosomal_L3_bac/org-type.
IPR019926. Ribosomal_L3_CS.
IPR009000. Transl_B-barrel.
[Graphical view ]
PANTHERi PTHR11229. PTHR11229. 1 hit.
Pfami PF00297. Ribosomal_L3. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
TIGRFAMsi TIGR03625. L3_bact. 1 hit.
PROSITEi PS00474. RIBOSOMAL_L3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
    Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
    Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, PROTEIN SEQUENCE OF 1-5.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
    Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
    Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
    Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
    Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  5. "Structural basis for the antibiotic activity of ketolides and azalides."
    Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
    Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
    Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
    Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
    Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
    BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
    Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
    Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiRL3_DEIRA
AccessioniPrimary (citable) accession number: Q9RXK2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: May 1, 2000
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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