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Q9RXK0 (RL23_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L23
Gene names
Name:rplW
Ordered Locus Names:DR_0313
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One of the early assembly protein By similarity it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Forms the main docking site for trigger factor binding to the ribosome (Ref.9 and Ref.10). HAMAP-Rule MF_01369

Subunit structure

Part of the 50S ribosomal subunit. Contacts protein L29 and trigger factor when it is bound to the ribosome (Ref.9 and Ref.10). Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10

Sequence similarities

Belongs to the ribosomal protein L23P family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 959450S ribosomal protein L23 HAMAP-Rule MF_01369
PRO_0000129406

Secondary structure

.................. 95
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9RXK0 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 09D8AA73699D6046

FASTA9510,522
        10         20         30         40         50         60 
MSHYDILQAP VISEKAYSAM ERGVYSFWVS PKATKTEIKD AIQQAFGVRV IGISTMNVPG 

        70         80         90 
KRKRVGRFIG QRNDRKKAIV RLAEGQSIEA LAGQA 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1."
White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. expand/collapse author list , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Science 286:1571-1577(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[2]"High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-6, X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, CONTACTS WITH 23S RRNA, CONTACTS WITH L29.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[3]"Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[4]"Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[5]"Structural basis for the antibiotic activity of ketolides and azalides."
Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[6]"Structural insight into the role of the ribosomal tunnel in cellular regulation."
Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[7]"Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[8]"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[9]"Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action."
Baram D., Pyetan E., Sittner A., Auerbach-Nevo T., Bashan A., Yonath A.
Proc. Natl. Acad. Sci. U.S.A. 102:12017-12022(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.
[10]"The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction."
Schluenzen F., Wilson D.N., Tian P., Harms J.M., McInnes S.J., Hansen H.A.S., Albrecht R., Buerger J., Wilbanks S.M., Fucini P.
Structure 13:1685-1694(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF09894.1.
PIRA75534.
RefSeqNP_294036.1. NC_001263.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GS2model-R2-94[»]
1NKWX-ray3.10R1-95[»]
1NWXX-ray3.50R2-95[»]
1NWYX-ray3.30R2-95[»]
1PNUX-ray8.70R2-94[»]
1PNYX-ray9.50R2-94[»]
1SM1X-ray3.42R1-95[»]
1VORX-ray11.50U2-94[»]
1VOUX-ray11.50U2-94[»]
1VP0X-ray11.50U2-94[»]
1XBPX-ray3.50R2-95[»]
2AARX-ray3.50R1-95[»]
2D3OX-ray3.35R1-95[»]
2ZJPX-ray3.70Q1-95[»]
2ZJQX-ray3.30Q1-95[»]
2ZJRX-ray2.91Q1-95[»]
3CF5X-ray3.30Q1-95[»]
3DLLX-ray3.50Q1-95[»]
3PIOX-ray3.25Q1-95[»]
3PIPX-ray3.45Q1-95[»]
4IO9X-ray3.20Q1-95[»]
4IOAX-ray3.20Q1-95[»]
4IOCX-ray3.60Q1-95[»]
ProteinModelPortalQ9RXK0.
SMRQ9RXK0. Positions 2-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0313.

Proteomic databases

PRIDEQ9RXK0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF09894; AAF09894; DR_0313.
GeneID1799376.
KEGGdra:DR_0313.
PATRIC21628124. VBIDeiRad64572_0479.

Phylogenomic databases

eggNOGCOG0089.
HOGENOMHOG000231366.
KOK02892.
OMAGKTKRMG.
OrthoDBEOG6HTP4P.

Enzyme and pathway databases

BioCycDRAD243230:GH46-323-MONOMER.

Family and domain databases

Gene3D3.30.70.330. 1 hit.
HAMAPMF_01369_B. Ribosomal_L23_B.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR012678. Ribosomal_L23/L15e_core_dom.
IPR001014. Ribosomal_L23/L25_CS.
IPR013025. Ribosomal_L25/23.
[Graphical view]
PfamPF00276. Ribosomal_L23. 1 hit.
[Graphical view]
SUPFAMSSF54189. SSF54189. 1 hit.
PROSITEPS00050. RIBOSOMAL_L23. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9RXK0.

Entry information

Entry nameRL23_DEIRA
AccessionPrimary (citable) accession number: Q9RXK0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references