Reviewed, UniProtKB/Swiss-Prot Q9RXJ4 (RL29_DEIRA)

Names and origin

Protein names

Recommended name:
    50S ribosomal protein L29

Gene names

Name:	rpmC
Ordered Locus Names:	DR_0319

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	67 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds the 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. HAMAP MF_00374
Subunit structure	Part of the 50S ribosomal subunit. Contacts protein L23 and trigger factor when it is complexed with the ribosome (Ref.9 and Ref.10). Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10
Sequence similarities	Belongs to the ribosomal protein L29P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 67

67

50S ribosomal protein L29 HAMAP MF_00374

PRO_0000130383

Secondary structure

1

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67

Helix Strand Turn

Details...

Turn

4 – 8

5

Beta strand

11 – 13

3

Helix

15 – 17

3

Helix

18 – 29

12

Turn

30 – 35

6

Helix

41 – 54

14

Helix

56 – 59

4

Turn

60 – 65

6

Sequences

	Sequence		Length	Mass (Da)
	Q9RXJ4-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E4A9DB4CCE58932F	FASTA	67	7,760
	10 20 30 40 50 60 MKPSEMRNLQ ATDFAKEIDA RKKELMELRF QAAAGQLAQP HRVRQLRREV AQLNTVKAEL ARKGEQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[2]	"High resolution structure of the large ribosomal subunit from a mesophilic eubacterium." Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A. Cell 107:679-688(2001) [PubMed: 11733066] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-5, X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[3]	"Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria." Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F. Nature 413:814-821(2001) [PubMed: 11677599] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[4]	"Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression." Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A. Mol. Cell 11:91-102(2003) [PubMed: 12535524] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[5]	"Structural basis for the antibiotic activity of ketolides and azalides." Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A. Structure 11:329-338(2003) [PubMed: 12623020] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[6]	"Structural insight into the role of the ribosomal tunnel in cellular regulation." Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A. Nat. Struct. Biol. 10:366-370(2003) [PubMed: 12665853] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[7]	"Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin." Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A. BMC Biol. 2:4-4(2004) [PubMed: 15059283] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[8]	"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin." Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M. Mol. Microbiol. 54:1287-1294(2004) [PubMed: 15554968] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[9]	"Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action." Baram D., Pyetan E., Sittner A., Auerbach-Nevo T., Bashan A., Yonath A. Proc. Natl. Acad. Sci. U.S.A. 102:12017-12022(2005) [PubMed: 16091460] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.
[10]	"The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction." Schluenzen F., Wilson D.N., Tian P., Harms J.M., McInnes S.J., Hansen H.A.S., Albrecht R., Buerger J., Wilbanks S.M., Fucini P. Structure 13:1685-1694(2005) [PubMed: 16271892] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000513 Genomic DNA. Translation: AAF09900.1.

PIR

G75534.

RefSeq

NP_294042.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NKW	X-ray	3.10	W	1-67	[»]
1NWX	X-ray	3.50	W	1-67	[»]
1NWY	X-ray	3.30	W	1-67	[»]
1PNU	X-ray	8.70	W	2-66	[»]
1PNY	X-ray	9.50	W	2-66	[»]
1SM1	X-ray	3.42	W	1-67	[»]
1XBP	X-ray	3.50	W	1-67	[»]
2AAR	X-ray	3.50	W	1-67	[»]
2D3O	X-ray	3.35	W	1-67	[»]
2ZJP	X-ray	3.70	V	1-67	[»]
2ZJQ	X-ray	3.30	V	1-67	[»]
2ZJR	X-ray	2.91	V	1-67	[»]
3CF5	X-ray	3.30	V	1-67	[»]
3DLL	X-ray	3.50	V	1-67	[»]

ModBase

Search...

Genome annotation databases

GeneID

1800092.

GenomeReviews

Gene locus DR_0319 in contig AE000513_GR.

KEGG

dra:DR_0319.

NMPDR

fig|243230.1.peg.501.

TIGR

DR_0319.

Phylogenomic databases

HOGENOM

Q9RXJ4.

OMA

ARKKELM.

Enzyme and pathway databases

BioCyc

DRAD243230:DR_0319-MON.

Family and domain databases

HAMAP

MF_00374.
[Tree]

InterPro

IPR001854. Ribosomal_L29.
IPR018254. Ribosomal_L29_CS.
[Graphical view]

Gene3D

G3DSA:1.10.287.310. Ribosomal_L29. 1 hit.

Pfam

PF00831. Ribosomal_L29. 1 hit.
[Graphical view]

TIGRFAMs

TIGR00012. L29. 1 hit.

PROSITE

PS00579. RIBOSOMAL_L29. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RL29_DEIRA

Accession

Primary (citable) accession number: Q9RXJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)