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Q9RXJ4

- RL29_DEIRA

UniProt

Q9RXJ4 - RL29_DEIRA

Protein

50S ribosomal protein L29

Gene

rpmC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Binds the 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-329-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L29
    Gene namesi
    Name:rpmC
    Ordered Locus Names:DR_0319
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 676750S ribosomal protein L29PRO_0000130383Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Contacts protein L23 and trigger factor when it is complexed with the ribosome (PubMed:16091460 and PubMed:16271892).8 Publications

    Protein-protein interaction databases

    STRINGi243230.DR_0319.

    Structurei

    Secondary structure

    1
    67
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni4 – 85
    Helixi11 – 199
    Helixi21 – 3414
    Helixi40 – 6021
    Turni61 – 655

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1NKWX-ray3.10W1-67[»]
    1NWXX-ray3.50W1-67[»]
    1NWYX-ray3.30W1-67[»]
    1PNUX-ray8.70W2-66[»]
    1PNYX-ray9.50W2-66[»]
    1SM1X-ray3.42W1-67[»]
    1VORX-ray11.50Y2-66[»]
    1VOYX-ray11.50Y2-66[»]
    1VP0X-ray11.50Y2-66[»]
    1XBPX-ray3.50W1-67[»]
    2AARX-ray3.50W1-67[»]
    2D3OX-ray3.35W1-67[»]
    2ZJPX-ray3.70V1-67[»]
    2ZJQX-ray3.30V1-67[»]
    2ZJRX-ray2.91V1-67[»]
    3CF5X-ray3.30V1-67[»]
    3DLLX-ray3.50V1-67[»]
    3PIOX-ray3.25V1-67[»]
    3PIPX-ray3.45V1-67[»]
    4IO9X-ray3.20V1-67[»]
    4IOAX-ray3.20V1-67[»]
    4IOCX-ray3.60V1-67[»]
    ProteinModelPortaliQ9RXJ4.
    SMRiQ9RXJ4. Positions 1-66.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9RXJ4.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L29P family.Curated

    Phylogenomic databases

    eggNOGiCOG0255.
    HOGENOMiHOG000248755.
    KOiK02904.
    OMAiMKPSDMR.
    OrthoDBiEOG6VTK8Z.

    Family and domain databases

    Gene3Di1.10.287.310. 1 hit.
    HAMAPiMF_00374. Ribosomal_L29.
    InterProiIPR001854. Ribosomal_L29.
    IPR018254. Ribosomal_L29_CS.
    [Graphical view]
    PfamiPF00831. Ribosomal_L29. 1 hit.
    [Graphical view]
    SUPFAMiSSF46561. SSF46561. 1 hit.
    TIGRFAMsiTIGR00012. L29. 1 hit.
    PROSITEiPS00579. RIBOSOMAL_L29. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RXJ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKPSEMRNLQ ATDFAKEIDA RKKELMELRF QAAAGQLAQP HRVRQLRREV   50
    AQLNTVKAEL ARKGEQQ 67
    Length:67
    Mass (Da):7,760
    Last modified:May 1, 2000 - v1
    Checksum:iE4A9DB4CCE58932F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF09900.1.
    PIRiG75534.
    RefSeqiNP_294042.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF09900; AAF09900; DR_0319.
    GeneIDi1800092.
    KEGGidra:DR_0319.
    PATRICi21628136. VBIDeiRad64572_0485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF09900.1 .
    PIRi G75534.
    RefSeqi NP_294042.1. NC_001263.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1NKW X-ray 3.10 W 1-67 [» ]
    1NWX X-ray 3.50 W 1-67 [» ]
    1NWY X-ray 3.30 W 1-67 [» ]
    1PNU X-ray 8.70 W 2-66 [» ]
    1PNY X-ray 9.50 W 2-66 [» ]
    1SM1 X-ray 3.42 W 1-67 [» ]
    1VOR X-ray 11.50 Y 2-66 [» ]
    1VOY X-ray 11.50 Y 2-66 [» ]
    1VP0 X-ray 11.50 Y 2-66 [» ]
    1XBP X-ray 3.50 W 1-67 [» ]
    2AAR X-ray 3.50 W 1-67 [» ]
    2D3O X-ray 3.35 W 1-67 [» ]
    2ZJP X-ray 3.70 V 1-67 [» ]
    2ZJQ X-ray 3.30 V 1-67 [» ]
    2ZJR X-ray 2.91 V 1-67 [» ]
    3CF5 X-ray 3.30 V 1-67 [» ]
    3DLL X-ray 3.50 V 1-67 [» ]
    3PIO X-ray 3.25 V 1-67 [» ]
    3PIP X-ray 3.45 V 1-67 [» ]
    4IO9 X-ray 3.20 V 1-67 [» ]
    4IOA X-ray 3.20 V 1-67 [» ]
    4IOC X-ray 3.60 V 1-67 [» ]
    ProteinModelPortali Q9RXJ4.
    SMRi Q9RXJ4. Positions 1-66.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_0319.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF09900 ; AAF09900 ; DR_0319 .
    GeneIDi 1800092.
    KEGGi dra:DR_0319.
    PATRICi 21628136. VBIDeiRad64572_0485.

    Phylogenomic databases

    eggNOGi COG0255.
    HOGENOMi HOG000248755.
    KOi K02904.
    OMAi MKPSDMR.
    OrthoDBi EOG6VTK8Z.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-329-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9RXJ4.

    Family and domain databases

    Gene3Di 1.10.287.310. 1 hit.
    HAMAPi MF_00374. Ribosomal_L29.
    InterProi IPR001854. Ribosomal_L29.
    IPR018254. Ribosomal_L29_CS.
    [Graphical view ]
    Pfami PF00831. Ribosomal_L29. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46561. SSF46561. 1 hit.
    TIGRFAMsi TIGR00012. L29. 1 hit.
    PROSITEi PS00579. RIBOSOMAL_L29. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
      Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
      Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-5, X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
      Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
      Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
      Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
      Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    5. "Structural basis for the antibiotic activity of ketolides and azalides."
      Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
      Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
      Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
      Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
      Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
      BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
      Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
      Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    9. "Structure of trigger factor binding domain in biologically homologous complex with eubacterial ribosome reveals its chaperone action."
      Baram D., Pyetan E., Sittner A., Auerbach-Nevo T., Bashan A., Yonath A.
      Proc. Natl. Acad. Sci. U.S.A. 102:12017-12022(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.
    10. "The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction."
      Schluenzen F., Wilson D.N., Tian P., Harms J.M., McInnes S.J., Hansen H.A.S., Albrecht R., Buerger J., Wilbanks S.M., Fucini P.
      Structure 13:1685-1694(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.

    Entry informationi

    Entry nameiRL29_DEIRA
    AccessioniPrimary (citable) accession number: Q9RXJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3