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Q9RXJ1

- RL24_DEIRA

UniProt

Q9RXJ1 - RL24_DEIRA

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Protein

50S ribosomal protein L24

Gene
rplX, DR_0322
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit By similarity.UniRule annotation
One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (TF) when it is bound to the ribosome; this contact may expose a hydrophobic crevice in TF (1 Publication).UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-332-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L24
Gene namesi
Name:rplX
Ordered Locus Names:DR_0322
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511550S ribosomal protein L24UniRule annotationPRO_0000130653Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit. Contacts trigger factor when it is bound to the ribosome (1 Publication).8 Publications

Protein-protein interaction databases

STRINGi243230.DR_0322.

Structurei

Secondary structure

1
115
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 73
Turni8 – 114
Beta strandi20 – 234
Beta strandi26 – 294
Beta strandi33 – 408
Turni41 – 444
Beta strandi45 – 517
Beta strandi52 – 565
Beta strandi62 – 643
Beta strandi69 – 735
Beta strandi78 – 825
Beta strandi84 – 896
Beta strandi108 – 1103

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GS2model-S2-115[»]
1NKWX-ray3.10S1-115[»]
1NWXX-ray3.50S1-115[»]
1NWYX-ray3.30S1-115[»]
1PNUX-ray8.70S2-114[»]
1PNYX-ray9.50S2-114[»]
1SM1X-ray3.42S1-115[»]
1VOUX-ray11.50V2-114[»]
1VOYX-ray11.50V2-114[»]
1VP0X-ray11.50V2-114[»]
1XBPX-ray3.50S1-115[»]
2D3OX-ray3.35S1-115[»]
2ZJPX-ray3.70R1-115[»]
2ZJQX-ray3.30R1-115[»]
2ZJRX-ray2.91R1-115[»]
3CF5X-ray3.30R1-115[»]
3DLLX-ray3.50R1-115[»]
3PIOX-ray3.25R1-115[»]
3PIPX-ray3.45R1-115[»]
4IO9X-ray3.20R1-115[»]
4IOAX-ray3.20R1-115[»]
4IOCX-ray3.60R1-115[»]
ProteinModelPortaliQ9RXJ1.
SMRiQ9RXJ1. Positions 2-114.

Miscellaneous databases

EvolutionaryTraceiQ9RXJ1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0198.
HOGENOMiHOG000039891.
KOiK02895.
OMAiNVAIFNQ.
OrthoDBiEOG6FFSDM.

Family and domain databases

Gene3Di2.30.30.30. 1 hit.
HAMAPiMF_01326_B. Ribosomal_L24_B.
InterProiIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERiPTHR12903. PTHR12903. 1 hit.
PfamiPF00467. KOW. 1 hit.
[Graphical view]
SMARTiSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMiSSF50104. SSF50104. 1 hit.
TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RXJ1-1 [UniParc]FASTAAdd to Basket

« Hide

MPRPSAGSHH NDKLHFKKGD TVIVLSGKHK GQTGKVLLAL PRDQKVVVEG    50
VNVITKNVKP SMTNPQGGQE QRELALHASK VALVDPETGK ATRVRKQIVD 100
GKKVRVAVAS GKTID 115
Length:115
Mass (Da):12,358
Last modified:May 1, 2000 - v1
Checksum:iFE0A0ABC51477BE1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF09903.1.
PIRiB75535.
RefSeqiNP_294045.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF09903; AAF09903; DR_0322.
GeneIDi1798682.
KEGGidra:DR_0322.
PATRICi21628142. VBIDeiRad64572_0488.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF09903.1 .
PIRi B75535.
RefSeqi NP_294045.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1GS2 model - S 2-115 [» ]
1NKW X-ray 3.10 S 1-115 [» ]
1NWX X-ray 3.50 S 1-115 [» ]
1NWY X-ray 3.30 S 1-115 [» ]
1PNU X-ray 8.70 S 2-114 [» ]
1PNY X-ray 9.50 S 2-114 [» ]
1SM1 X-ray 3.42 S 1-115 [» ]
1VOU X-ray 11.50 V 2-114 [» ]
1VOY X-ray 11.50 V 2-114 [» ]
1VP0 X-ray 11.50 V 2-114 [» ]
1XBP X-ray 3.50 S 1-115 [» ]
2D3O X-ray 3.35 S 1-115 [» ]
2ZJP X-ray 3.70 R 1-115 [» ]
2ZJQ X-ray 3.30 R 1-115 [» ]
2ZJR X-ray 2.91 R 1-115 [» ]
3CF5 X-ray 3.30 R 1-115 [» ]
3DLL X-ray 3.50 R 1-115 [» ]
3PIO X-ray 3.25 R 1-115 [» ]
3PIP X-ray 3.45 R 1-115 [» ]
4IO9 X-ray 3.20 R 1-115 [» ]
4IOA X-ray 3.20 R 1-115 [» ]
4IOC X-ray 3.60 R 1-115 [» ]
ProteinModelPortali Q9RXJ1.
SMRi Q9RXJ1. Positions 2-114.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_0322.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF09903 ; AAF09903 ; DR_0322 .
GeneIDi 1798682.
KEGGi dra:DR_0322.
PATRICi 21628142. VBIDeiRad64572_0488.

Phylogenomic databases

eggNOGi COG0198.
HOGENOMi HOG000039891.
KOi K02895.
OMAi NVAIFNQ.
OrthoDBi EOG6FFSDM.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-332-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9RXJ1.

Family and domain databases

Gene3Di 2.30.30.30. 1 hit.
HAMAPi MF_01326_B. Ribosomal_L24_B.
InterProi IPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view ]
PANTHERi PTHR12903. PTHR12903. 1 hit.
Pfami PF00467. KOW. 1 hit.
[Graphical view ]
SMARTi SM00739. KOW. 1 hit.
[Graphical view ]
SUPFAMi SSF50104. SSF50104. 1 hit.
TIGRFAMsi TIGR01079. rplX_bact. 1 hit.
PROSITEi PS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
    Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
    Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-5, X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
    Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
    Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
    Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
    Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  5. "Structural basis for the antibiotic activity of ketolides and azalides."
    Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
    Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
    Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
    Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
    Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
    BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
    Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
    Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  9. "The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction."
    Schluenzen F., Wilson D.N., Tian P., Harms J.M., McInnes S.J., Hansen H.A.S., Albrecht R., Buerger J., Wilbanks S.M., Fucini P.
    Structure 13:1685-1694(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.

Entry informationi

Entry nameiRL24_DEIRA
AccessioniPrimary (citable) accession number: Q9RXJ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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