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Q9RXJ1

- RL24_DEIRA

UniProt

Q9RXJ1 - RL24_DEIRA

Protein

50S ribosomal protein L24

Gene

rplX

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.By similarity
    One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (TF) when it is bound to the ribosome; this contact may expose a hydrophobic crevice in TF (PubMed:16271892).1 Publication

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-KW
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-332-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L24
    Gene namesi
    Name:rplX
    Ordered Locus Names:DR_0322
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11511550S ribosomal protein L24PRO_0000130653Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit. Contacts trigger factor when it is bound to the ribosome (PubMed:16271892).7 Publications

    Protein-protein interaction databases

    STRINGi243230.DR_0322.

    Structurei

    Secondary structure

    1
    115
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 73
    Turni8 – 114
    Beta strandi20 – 234
    Beta strandi26 – 294
    Beta strandi33 – 408
    Turni41 – 444
    Beta strandi45 – 517
    Beta strandi52 – 565
    Beta strandi62 – 643
    Beta strandi69 – 735
    Beta strandi78 – 825
    Beta strandi84 – 896
    Beta strandi108 – 1103

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1GS2model-S2-115[»]
    1NKWX-ray3.10S1-115[»]
    1NWXX-ray3.50S1-115[»]
    1NWYX-ray3.30S1-115[»]
    1PNUX-ray8.70S2-114[»]
    1PNYX-ray9.50S2-114[»]
    1SM1X-ray3.42S1-115[»]
    1VOUX-ray11.50V2-114[»]
    1VOYX-ray11.50V2-114[»]
    1VP0X-ray11.50V2-114[»]
    1XBPX-ray3.50S1-115[»]
    2D3OX-ray3.35S1-115[»]
    2ZJPX-ray3.70R1-115[»]
    2ZJQX-ray3.30R1-115[»]
    2ZJRX-ray2.91R1-115[»]
    3CF5X-ray3.30R1-115[»]
    3DLLX-ray3.50R1-115[»]
    3PIOX-ray3.25R1-115[»]
    3PIPX-ray3.45R1-115[»]
    4IO9X-ray3.20R1-115[»]
    4IOAX-ray3.20R1-115[»]
    4IOCX-ray3.60R1-115[»]
    ProteinModelPortaliQ9RXJ1.
    SMRiQ9RXJ1. Positions 2-114.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9RXJ1.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L24P family.Curated

    Phylogenomic databases

    eggNOGiCOG0198.
    HOGENOMiHOG000039891.
    KOiK02895.
    OMAiNVAIFNQ.
    OrthoDBiEOG6FFSDM.

    Family and domain databases

    Gene3Di2.30.30.30. 1 hit.
    HAMAPiMF_01326_B. Ribosomal_L24_B.
    InterProiIPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR003256. Ribosomal_L24.
    IPR005825. Ribosomal_L24/26_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view]
    PANTHERiPTHR12903. PTHR12903. 1 hit.
    PfamiPF00467. KOW. 1 hit.
    [Graphical view]
    SMARTiSM00739. KOW. 1 hit.
    [Graphical view]
    SUPFAMiSSF50104. SSF50104. 1 hit.
    TIGRFAMsiTIGR01079. rplX_bact. 1 hit.
    PROSITEiPS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RXJ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPRPSAGSHH NDKLHFKKGD TVIVLSGKHK GQTGKVLLAL PRDQKVVVEG    50
    VNVITKNVKP SMTNPQGGQE QRELALHASK VALVDPETGK ATRVRKQIVD 100
    GKKVRVAVAS GKTID 115
    Length:115
    Mass (Da):12,358
    Last modified:May 1, 2000 - v1
    Checksum:iFE0A0ABC51477BE1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF09903.1.
    PIRiB75535.
    RefSeqiNP_294045.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF09903; AAF09903; DR_0322.
    GeneIDi1798682.
    KEGGidra:DR_0322.
    PATRICi21628142. VBIDeiRad64572_0488.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF09903.1 .
    PIRi B75535.
    RefSeqi NP_294045.1. NC_001263.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1GS2 model - S 2-115 [» ]
    1NKW X-ray 3.10 S 1-115 [» ]
    1NWX X-ray 3.50 S 1-115 [» ]
    1NWY X-ray 3.30 S 1-115 [» ]
    1PNU X-ray 8.70 S 2-114 [» ]
    1PNY X-ray 9.50 S 2-114 [» ]
    1SM1 X-ray 3.42 S 1-115 [» ]
    1VOU X-ray 11.50 V 2-114 [» ]
    1VOY X-ray 11.50 V 2-114 [» ]
    1VP0 X-ray 11.50 V 2-114 [» ]
    1XBP X-ray 3.50 S 1-115 [» ]
    2D3O X-ray 3.35 S 1-115 [» ]
    2ZJP X-ray 3.70 R 1-115 [» ]
    2ZJQ X-ray 3.30 R 1-115 [» ]
    2ZJR X-ray 2.91 R 1-115 [» ]
    3CF5 X-ray 3.30 R 1-115 [» ]
    3DLL X-ray 3.50 R 1-115 [» ]
    3PIO X-ray 3.25 R 1-115 [» ]
    3PIP X-ray 3.45 R 1-115 [» ]
    4IO9 X-ray 3.20 R 1-115 [» ]
    4IOA X-ray 3.20 R 1-115 [» ]
    4IOC X-ray 3.60 R 1-115 [» ]
    ProteinModelPortali Q9RXJ1.
    SMRi Q9RXJ1. Positions 2-114.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_0322.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF09903 ; AAF09903 ; DR_0322 .
    GeneIDi 1798682.
    KEGGi dra:DR_0322.
    PATRICi 21628142. VBIDeiRad64572_0488.

    Phylogenomic databases

    eggNOGi COG0198.
    HOGENOMi HOG000039891.
    KOi K02895.
    OMAi NVAIFNQ.
    OrthoDBi EOG6FFSDM.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-332-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9RXJ1.

    Family and domain databases

    Gene3Di 2.30.30.30. 1 hit.
    HAMAPi MF_01326_B. Ribosomal_L24_B.
    InterProi IPR005824. KOW.
    IPR014722. Rib_L2_dom2.
    IPR003256. Ribosomal_L24.
    IPR005825. Ribosomal_L24/26_CS.
    IPR008991. Translation_prot_SH3-like.
    [Graphical view ]
    PANTHERi PTHR12903. PTHR12903. 1 hit.
    Pfami PF00467. KOW. 1 hit.
    [Graphical view ]
    SMARTi SM00739. KOW. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50104. SSF50104. 1 hit.
    TIGRFAMsi TIGR01079. rplX_bact. 1 hit.
    PROSITEi PS01108. RIBOSOMAL_L24. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    2. "High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
      Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
      Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-5, X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    3. "Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
      Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
      Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    4. "Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
      Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
      Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    5. "Structural basis for the antibiotic activity of ketolides and azalides."
      Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
      Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    6. "Structural insight into the role of the ribosomal tunnel in cellular regulation."
      Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
      Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    7. "Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
      Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
      BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    8. "Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
      Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
      Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
    9. "The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction."
      Schluenzen F., Wilson D.N., Tian P., Harms J.M., McInnes S.J., Hansen H.A.S., Albrecht R., Buerger J., Wilbanks S.M., Fucini P.
      Structure 13:1685-1694(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.

    Entry informationi

    Entry nameiRL24_DEIRA
    AccessioniPrimary (citable) accession number: Q9RXJ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 15, 2004
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3