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Q9RXJ1 (RL24_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L24
Gene names
Name:rplX
Ordered Locus Names:DR_0322
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length115 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit By similarity. HAMAP-Rule MF_01326_B

One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. Contacts trigger factor (TF) when it is bound to the ribosome; this contact may expose a hydrophobic crevice in TF (Ref.9). HAMAP-Rule MF_01326_B

Subunit structure

Part of the 50S ribosomal subunit. Contacts trigger factor when it is bound to the ribosome (Ref.9). Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8 Ref.9

Sequence similarities

Belongs to the ribosomal protein L24P family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11511550S ribosomal protein L24 HAMAP-Rule MF_01326_B
PRO_0000130653

Secondary structure

....................... 115
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9RXJ1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: FE0A0ABC51477BE1

FASTA11512,358
        10         20         30         40         50         60 
MPRPSAGSHH NDKLHFKKGD TVIVLSGKHK GQTGKVLLAL PRDQKVVVEG VNVITKNVKP 

        70         80         90        100        110 
SMTNPQGGQE QRELALHASK VALVDPETGK ATRVRKQIVD GKKVRVAVAS GKTID 

« Hide

References

« Hide 'large scale' references
[1]"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1."
White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. expand/collapse author list , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M.
Science 286:1571-1577(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[2]"High resolution structure of the large ribosomal subunit from a mesophilic eubacterium."
Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A.
Cell 107:679-688(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-5, X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[3]"Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria."
Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F.
Nature 413:814-821(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[4]"Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression."
Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A.
Mol. Cell 11:91-102(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[5]"Structural basis for the antibiotic activity of ketolides and azalides."
Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A.
Structure 11:329-338(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[6]"Structural insight into the role of the ribosomal tunnel in cellular regulation."
Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A.
Nat. Struct. Biol. 10:366-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[7]"Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin."
Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A.
BMC Biol. 2:4-4(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[8]"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin."
Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M.
Mol. Microbiol. 54:1287-1294(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN.
Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
[9]"The binding mode of the trigger factor on the ribosome: implications for protein folding and SRP interaction."
Schluenzen F., Wilson D.N., Tian P., Harms J.M., McInnes S.J., Hansen H.A.S., Albrecht R., Buerger J., Wilbanks S.M., Fucini P.
Structure 13:1685-1694(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRIGGER FACTOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF09903.1.
PIRB75535.
RefSeqNP_294045.1. NC_001263.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1GS2model-S2-115[»]
1NKWX-ray3.10S1-115[»]
1NWXX-ray3.50S1-115[»]
1NWYX-ray3.30S1-115[»]
1PNUX-ray8.70S2-114[»]
1PNYX-ray9.50S2-114[»]
1SM1X-ray3.42S1-115[»]
1VOUX-ray11.50V2-114[»]
1VOYX-ray11.50V2-114[»]
1VP0X-ray11.50V2-114[»]
1XBPX-ray3.50S1-115[»]
2D3OX-ray3.35S1-115[»]
2ZJPX-ray3.70R1-115[»]
2ZJQX-ray3.30R1-115[»]
2ZJRX-ray2.91R1-115[»]
3CF5X-ray3.30R1-115[»]
3DLLX-ray3.50R1-115[»]
3PIOX-ray3.25R1-115[»]
3PIPX-ray3.45R1-115[»]
4IO9X-ray3.20R1-115[»]
4IOAX-ray3.20R1-115[»]
4IOCX-ray3.60R1-115[»]
ProteinModelPortalQ9RXJ1.
SMRQ9RXJ1. Positions 2-114.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0322.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF09903; AAF09903; DR_0322.
GeneID1798682.
KEGGdra:DR_0322.
PATRIC21628142. VBIDeiRad64572_0488.

Phylogenomic databases

eggNOGCOG0198.
HOGENOMHOG000039891.
KOK02895.
OMANVAIFNQ.
OrthoDBEOG6FFSDM.

Enzyme and pathway databases

BioCycDRAD243230:GH46-332-MONOMER.

Family and domain databases

Gene3D2.30.30.30. 1 hit.
HAMAPMF_01326_B. Ribosomal_L24_B.
InterProIPR005824. KOW.
IPR014722. Rib_L2_dom2.
IPR003256. Ribosomal_L24.
IPR005825. Ribosomal_L24/26_CS.
IPR008991. Translation_prot_SH3-like.
[Graphical view]
PANTHERPTHR12903. PTHR12903. 1 hit.
PfamPF00467. KOW. 1 hit.
[Graphical view]
SMARTSM00739. KOW. 1 hit.
[Graphical view]
SUPFAMSSF50104. SSF50104. 1 hit.
TIGRFAMsTIGR01079. rplX_bact. 1 hit.
PROSITEPS01108. RIBOSOMAL_L24. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ9RXJ1.

Entry information

Entry nameRL24_DEIRA
AccessionPrimary (citable) accession number: Q9RXJ1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: May 1, 2000
Last modified: July 9, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references