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Q9RX75 (RUVC_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Crossover junction endodeoxyribonuclease RuvC

EC=3.1.22.4
Alternative name(s):
Holliday junction nuclease RuvC
Holliday junction resolvase RuvC
Gene names
Name:ruvC
Ordered Locus Names:DR_0440
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length179 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group By similarity. HAMAP-Rule MF_00034

Catalytic activity

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). HAMAP-Rule MF_00034

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00034

Sequence similarities

Belongs to the RuvC family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 179179Crossover junction endodeoxyribonuclease RuvC HAMAP-Rule MF_00034
PRO_0000183095

Sites

Metal binding71Magnesium By similarity
Metal binding671Magnesium By similarity
Metal binding1391Magnesium By similarity
Metal binding1421Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RX75 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 3D0C4FFE232B9970

FASTA17919,652
        10         20         30         40         50         60 
MRVLGIDPGL ANLGLGLVEG DVRRAKHLYH VCLTTESAWL MPRRLQYLHE ELTRLLTEYR 

        70         80         90        100        110        120 
PDAVAIEDQI LRRQADVAFK VGQAFGVVQL ACAQAGVPIH AYGPMQVKKS LVGTGRADKE 

       130        140        150        160        170 
QVIYMVKASL GIRELFNNHA ADALALALTH LAHAPMQERS ERLAAAGRAA RTGDAPLRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF10018.1.
PIRF75519.
RefSeqNP_294163.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RX75.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0440.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF10018; AAF10018; DR_0440.
GeneID1799332.
KEGGdra:DR_0440.
PATRIC21628398. VBIDeiRad64572_0615.

Phylogenomic databases

eggNOGCOG0817.
HOGENOMHOG000012182.
KOK01159.
OMARTINDVF.
OrthoDBEOG6RG044.

Enzyme and pathway databases

BioCycDRAD243230:GH46-451-MONOMER.

Family and domain databases

Gene3D3.30.420.10. 1 hit.
HAMAPMF_00034. RuvC.
InterProIPR012337. RNaseH-like_dom.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSPR00696. RSOLVASERUVC.
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00228. ruvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRUVC_DEIRA
AccessionPrimary (citable) accession number: Q9RX75
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families