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Q9RX61 (UPPP_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Synonyms:bacA, upk
Ordered Locus Names:DR_0454
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_0000151143

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane42 – 6221Helical; Potential
Transmembrane81 – 10121Helical; Potential
Transmembrane107 – 12721Helical; Potential
Transmembrane142 – 16221Helical; Potential
Transmembrane184 – 20421Helical; Potential
Transmembrane213 – 23321Helical; Potential
Transmembrane248 – 26821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9RX61 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 59E4B9CCD47A86FC

FASTA27429,692
        10         20         30         40         50         60 
MDWLYSLIYG IVEGITEFLP ISSTGHLILT GNLLHVPWPK EVKDTFEVVI QGGAILAVLV 

        70         80         90        100        110        120 
YYWRDFLKIR HIGHDRGQQR LWLGVVLACI PAVILGVLFG DTIKAYLFRP SVVAWALIVG 

       130        140        150        160        170        180 
GVLMWLLESR KATPDTHDIE NISAGKALAI GAAQCLALLW PGFSRSASSI LGGMLLGLDR 

       190        200        210        220        230        240 
PTATKFSFYL GVPTLGGAAL LDFIKSREIL AQIGVVNVAI GAVTSFVVAY FAIGWLLRFV 

       250        260        270 
STNNFKGFAV YRVVVGVLIL VLIARGVLQN GSLA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF10030.1.
PIRB75518.
RefSeqNP_294177.1. NC_001263.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0454.

Proteomic databases

PRIDEQ9RX61.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF10030; AAF10030; DR_0454.
GeneID1799195.
KEGGdra:DR_0454.
PATRIC21628428. VBIDeiRad64572_0630.

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218356.
KOK06153.
OMAFNDAHAK.
OrthoDBEOG6QP13M.

Enzyme and pathway databases

BioCycDRAD243230:GH46-465-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
TIGRFAMsTIGR00753. undec_PP_bacA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameUPPP_DEIRA
AccessionPrimary (citable) accession number: Q9RX61
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families