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Q9RX51 (TREZ_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Malto-oligosyltrehalose trehalohydrolase
Short name=MTHase
EC=3.2.1.141
Alternative name(s):
4-alpha-D-((1->4)-alpha-D-glucano)trehalose trehalohydrolase
Maltooligosyl trehalose trehalohydrolase
Gene names
Name:treZ
Ordered Locus Names:DR_0464
OrganismDeinococcus radiodurans
Taxonomic identifier1299 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Hydrolysis of (1->4)-alpha-D-glucosidic linkage in 4-alpha-D-((1->4)-alpha-D-glucanosyl)(n) trehalose to yield trehalose and (1->4)-alpha-D-glucan.

Pathway

Glycan biosynthesis; trehalose biosynthesis.

Subunit structure

Monomer. Ref.2

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the glycosyl hydrolase 13 family.

Ontologies

Keywords
   Biological processCarbohydrate metabolism
   Cellular componentCytoplasm
   Molecular functionGlycosidase
Hydrolase
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological processtrehalose biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function4-alpha-D-{(1->4)-alpha-D-glucano}trehalose trehalohydrolase activity

Inferred from electronic annotation. Source: EC

cation binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 600600Malto-oligosyltrehalose trehalohydrolase
PRO_0000393750

Regions

Region328 – 3325Substrate binding

Sites

Active site2751Nucleophile Probable
Active site3081Proton donor Probable
Binding site3761Substrate
Site4001Transition state stabilizer Probable

Secondary structure

1 ........................................................................................ 600
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9RX51 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 594091EC093F8A44

FASTA60066,910
        10         20         30         40         50         60 
MTQTQPVTPT PPASFQTQHD PRTRLGATPL PGGAGTRFRL WTSTARTVAV RVNGTEHVMT 

        70         80         90        100        110        120 
SLGGGIYELE LPVGPGARYL FVLDGVPTPD PYARFLPDGV HGEAEVVDFG TFDWTDADWH 

       130        140        150        160        170        180 
GIKLADCVFY EVHVGTFTPE GTYRAAAEKL PYLKELGVTA IQVMPLAAFD GQRGWGYDGA 

       190        200        210        220        230        240 
AFYAPYAPYG RPEDLMALVD AAHRLGLGVF LDVVYNHFGP SGNYLSSYAP SYFTDRFSSA 

       250        260        270        280        290        300 
WGMGLDYAEP HMRRYVTGNA RMWLRDYHFD GLRLDATPYM TDDSETHILT ELAQEIHELG 

       310        320        330        340        350        360 
GTHLLLAEDH RNLPDLVTVN HLDGIWTDDF HHETRVTLTG EQEGYYAGYR GGAEALAYTI 

       370        380        390        400        410        420 
RRGWRYEGQF WAVKGEEHER GHPSDALEAP NFVYCIQNHD QIGNRPLGER LHQSDGVTLH 

       430        440        450        460        470        480 
EYRGAAALLL PMTPLLFQGQ EWAASTPFQF FSDHAGELGQ AVSEGRKKEF GGFSGFSGED 

       490        500        510        520        530        540 
VPDPQAEQTF LNSKLNWAER EGGEHARTLR LYRDLLRLRR EDPVLHNRQR ENLTTGHDGD 

       550        560        570        580        590        600 
VLWVRTVTGA GERVLLWNLG QDTRAVAEVK LPFTVPRRLL LHTEGREDLT LGAGEAVLVG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000513 Genomic DNA. Translation: AAF10042.1.
PIRH75516.
RefSeqNP_294187.1. NC_001263.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2BHUX-ray1.10A1-600[»]
2BHYX-ray1.50A1-600[»]
2BHZX-ray1.20A1-600[»]
2BXYX-ray1.75A1-600[»]
2BXZX-ray1.75A1-600[»]
2BY0X-ray1.55A1-600[»]
2BY1X-ray1.55A1-600[»]
2BY2X-ray1.50A1-600[»]
2BY3X-ray1.50A1-600[»]
ProteinModelPortalQ9RX51.
SMRQ9RX51. Positions 14-600.
ModBaseSearch...

Protein family/group databases

CAZyCBM48. Carbohydrate-Binding Module Family 48.
GH13. Glycoside Hydrolase Family 13.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1798275.
GenomeReviewsGene locus DR_0464 in contig AE000513_GR.
KEGGdra:DR_0464.
NMPDRfig|243230.1.peg.646.
PATRIC21628450. VBIDeiRad64572_0641.
TIGRDR_0464.

Phylogenomic databases

HOGENOMHBG367595.
OMAEGFVYQG.
PhylomeDBQ9RX51.
ProtClustDBCLSK444555.

Enzyme and pathway databases

BioCycDRAD243230:DR_0464-MONOMER.

Family and domain databases

InterProIPR015902. Alpha_amylase.
IPR006047. Glyco_hydro_13_cat_dom.
IPR004193. Glyco_hydro_13_N.
IPR013781. Glyco_hydro_subgr_catalytic.
IPR017853. Glycoside_hydrolase_SF.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR022567. Maltooligo_trehalose_bac_C.
IPR012768. Trehalose_TreZ.
[Graphical view]
Gene3DG3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits.
G3DSA:2.60.40.10. Ig-like_fold. 1 hit.
PANTHERPTHR10357. Alpha_amylase. 1 hit.
PTHR10357:SF21. PTHR10357:SF21. 1 hit.
PfamPF00128. Alpha-amylase. 1 hit.
PF02922. CBM_48. 1 hit.
PF11941. DUF3459. 1 hit.
[Graphical view]
PIRSFPIRSF006337. Trehalose_TreZ. 1 hit.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
SSF81296. Ig_E-set. 1 hit.
TIGRFAMsTIGR02402. Trehalose_TreZ. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTREZ_DEIRA
AccessionPrimary (citable) accession number: Q9RX51
Entry history
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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