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Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of tryptophan to tRNA(Trp).UniRule annotation

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei136L-tryptophanUniRule annotation1
Binding sitei187ATP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 11ATPUniRule annotation3
Nucleotide bindingi17 – 18ATPUniRule annotation2
Nucleotide bindingi148 – 150ATPUniRule annotation3
Nucleotide bindingi195 – 199ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligaseUniRule annotation (EC:6.1.1.2UniRule annotation)
Alternative name(s):
Tryptophanyl-tRNA synthetaseUniRule annotation
Short name:
TrpRSUniRule annotation
Gene namesi
Name:trpSUniRule annotation
Ordered Locus Names:DR_0558
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001366271 – 330Tryptophan--tRNA ligaseAdd BLAST330

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_0558

Structurei

3D structure databases

ProteinModelPortaliQ9RWV7
SMRiQ9RWV7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi10 – 18"HIGH" regionUniRule annotation9
Motifi195 – 199"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C31 Bacteria
COG0180 LUCA
HOGENOMiHOG000059939
InParanoidiQ9RWV7
KOiK01867
OMAiQRMTQFK
OrthoDBiPOG091H00I9

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q9RWV7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVFSGIQP TGDPHIGNYF GAMQNYVRLG EQYGKQSLYC VVDLHAITNP
60 70 80 90 100
GAFDPQTLAQ KTFDMAVANF AIGLDPSKVV FFVQSHVPEH QELSWIFTCV
110 120 130 140 150
TPVGELERMT QYKDKSAQFE SVPSGLLMYP ALMAADILLY KADIVPVGED
160 170 180 190 200
QTQHIELTRE IARKFNHNFG ETFTEPKAVY NKEALRIPGV DGQGKMSKSK
210 220 230 240 250
GNTIGILEPF GDIWQKLRVA PTDPARVRRT DPGDPDKCLI GDYHKLFSPP
260 270 280 290 300
ETLETVYQGC RTAGIGCVDC KKMLMTHITE HLDPIQTRAA QLRADPDYVR
310 320 330
DALRQGDQEA RAIASEVMDE VRQKVGFLKL
Length:330
Mass (Da):36,866
Last modified:May 1, 2000 - v1
Checksum:i79ECF3CD6DF618D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA Translation: AAF10134.1
PIRiH75505
RefSeqiNP_294281.1, NC_001263.1
WP_010887203.1, NZ_CP015081.1

Genome annotation databases

EnsemblBacteriaiAAF10134; AAF10134; DR_0558
GeneIDi1799235
KEGGidra:DR_0558
PATRICifig|243230.17.peg.733

Similar proteinsi

Entry informationi

Entry nameiSYW_DEIRA
AccessioniPrimary (citable) accession number: Q9RWV7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: March 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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