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Q9RWV7 (SYW_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tryptophan--tRNA ligase

EC=6.1.1.2
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name=TrpRS
Gene names
Name:trpS
Ordered Locus Names:DR_0558
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length330 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp). HAMAP-Rule MF_00140

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00140

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00140.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processtryptophanyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tryptophan-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 330330Tryptophan--tRNA ligase HAMAP-Rule MF_00140
PRO_0000136627

Regions

Motif10 – 189"HIGH" region HAMAP-Rule MF_00140
Motif195 – 1995"KMSKS" region HAMAP-Rule MF_00140

Sites

Binding site1981ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RWV7 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 79ECF3CD6DF618D6

FASTA33036,866
        10         20         30         40         50         60 
MSRVFSGIQP TGDPHIGNYF GAMQNYVRLG EQYGKQSLYC VVDLHAITNP GAFDPQTLAQ 

        70         80         90        100        110        120 
KTFDMAVANF AIGLDPSKVV FFVQSHVPEH QELSWIFTCV TPVGELERMT QYKDKSAQFE 

       130        140        150        160        170        180 
SVPSGLLMYP ALMAADILLY KADIVPVGED QTQHIELTRE IARKFNHNFG ETFTEPKAVY 

       190        200        210        220        230        240 
NKEALRIPGV DGQGKMSKSK GNTIGILEPF GDIWQKLRVA PTDPARVRRT DPGDPDKCLI 

       250        260        270        280        290        300 
GDYHKLFSPP ETLETVYQGC RTAGIGCVDC KKMLMTHITE HLDPIQTRAA QLRADPDYVR 

       310        320        330 
DALRQGDQEA RAIASEVMDE VRQKVGFLKL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF10134.1.
PIRH75505.
RefSeqNP_294281.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RWV7.
SMRQ9RWV7. Positions 1-329.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0558.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF10134; AAF10134; DR_0558.
GeneID1799235.
KEGGdra:DR_0558.
PATRIC21628640. VBIDeiRad64572_0733.

Phylogenomic databases

eggNOGCOG0180.
HOGENOMHOG000059939.
KOK01867.
OMAREFREDQ.
OrthoDBEOG686NJQ.

Enzyme and pathway databases

BioCycDRAD243230:GH46-572-MONOMER.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00140_B. Trp_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERPTHR10055. PTHR10055. 1 hit.
PfamPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSPR01039. TRNASYNTHTRP.
TIGRFAMsTIGR00233. trpS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYW_DEIRA
AccessionPrimary (citable) accession number: Q9RWV7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries