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Protein

Uracil-DNA glycosylase

Gene

ung

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.UniRule annotation

Catalytic activityi

Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Keywords - Biological processi

DNA damage, DNA repair

Enzyme and pathway databases

BRENDAi3.2.2.27. 1856.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylaseUniRule annotation (EC:3.2.2.27UniRule annotation)
Short name:
UDGUniRule annotation
Gene namesi
Name:ungUniRule annotation
Ordered Locus Names:DR_0689
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001760901 – 247Uracil-DNA glycosylaseAdd BLAST247

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_0689.

Structurei

Secondary structure

1247
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi25 – 35Combined sources11
Helixi38 – 53Combined sources16
Beta strandi56 – 58Combined sources3
Helixi60 – 62Combined sources3
Helixi65 – 69Combined sources5
Helixi72 – 74Combined sources3
Beta strandi76 – 83Combined sources8
Turni88 – 90Combined sources3
Beta strandi92 – 94Combined sources3
Helixi106 – 118Combined sources13
Helixi131 – 134Combined sources4
Turni135 – 137Combined sources3
Beta strandi138 – 144Combined sources7
Turni152 – 157Combined sources6
Helixi160 – 172Combined sources13
Beta strandi179 – 184Combined sources6
Helixi185 – 188Combined sources4
Helixi189 – 193Combined sources5
Beta strandi200 – 204Combined sources5
Helixi209 – 214Combined sources6
Turni215 – 217Combined sources3
Helixi220 – 230Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BOOX-ray1.80A1-247[»]
3UFMX-ray1.95A1-247[»]
4UQMX-ray1.35A1-247[»]
ProteinModelPortaliQ9RWH9.
SMRiQ9RWH9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RWH9.

Family & Domainsi

Sequence similaritiesi

Belongs to the uracil-DNA glycosylase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
InParanoidiQ9RWH9.
KOiK03648.
OMAiIALIPKN.
OrthoDBiPOG091H03VL.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RWH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQPDLFGL APDAPRPIIP ANLPEDWQEA LLPEFSAPYF HELTDFLRQE
60 70 80 90 100
RKEYTIYPPA PDVFNALRYT PLGEVKVLIL GQDPYHGPNQ AHGLSFSVRP
110 120 130 140 150
GVRVPPSLRN IYKELTEDIP GFVAPKHGYL RSWAEQGVLL LNAVLTVRAG
160 170 180 190 200
QANSHQGKGW EHFTDAVIKA VNAKEERVVF ILWGSYARKK KKLITGKNHV
210 220 230 240
VIESGHPSPL SEQYFFGTRP FSKTNEALEK AGRGPVEWQL PATVTEE
Length:247
Mass (Da):27,746
Last modified:May 1, 2000 - v1
Checksum:iB92EB3319AFF4736
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10269.1.
PIRiF75486.
RefSeqiNP_294412.1. NC_001263.1.
WP_010887334.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF10269; AAF10269; DR_0689.
GeneIDi1799980.
KEGGidra:DR_0689.
PATRICi21628922. VBIDeiRad64572_0867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10269.1.
PIRiF75486.
RefSeqiNP_294412.1. NC_001263.1.
WP_010887334.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BOOX-ray1.80A1-247[»]
3UFMX-ray1.95A1-247[»]
4UQMX-ray1.35A1-247[»]
ProteinModelPortaliQ9RWH9.
SMRiQ9RWH9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_0689.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10269; AAF10269; DR_0689.
GeneIDi1799980.
KEGGidra:DR_0689.
PATRICi21628922. VBIDeiRad64572_0867.

Phylogenomic databases

eggNOGiENOG4105D5S. Bacteria.
COG0692. LUCA.
HOGENOMiHOG000229528.
InParanoidiQ9RWH9.
KOiK03648.
OMAiIALIPKN.
OrthoDBiPOG091H03VL.

Enzyme and pathway databases

BRENDAi3.2.2.27. 1856.

Miscellaneous databases

EvolutionaryTraceiQ9RWH9.

Family and domain databases

CDDicd10027. UDG_F1. 1 hit.
Gene3Di3.40.470.10. 1 hit.
HAMAPiMF_00148. UDG. 1 hit.
InterProiIPR002043. UDG_fam1.
IPR018085. Ura-DNA_Glyclase_AS.
IPR005122. Uracil-DNA_glycosylase-like.
[Graphical view]
PANTHERiPTHR11264. PTHR11264. 1 hit.
PfamiPF03167. UDG. 1 hit.
[Graphical view]
SMARTiSM00986. UDG. 1 hit.
[Graphical view]
SUPFAMiSSF52141. SSF52141. 1 hit.
TIGRFAMsiTIGR00628. ung. 1 hit.
PROSITEiPS00130. U_DNA_GLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUNG_DEIRA
AccessioniPrimary (citable) accession number: Q9RWH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.