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Q9RWD6 (HIS2_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histidine biosynthesis bifunctional protein HisIE

Including the following 2 domains:

  1. Phosphoribosyl-AMP cyclohydrolase
    Short name=PRA-CH
    EC=3.5.4.19
  2. Phosphoribosyl-ATP pyrophosphatase
    Short name=PRA-PH
    EC=3.6.1.31
Gene names
Name:hisI
Synonyms:hisIE
Ordered Locus Names:DR_0733
OrganismDeinococcus radiodurans
Taxonomic identifier1299 [NCBI]
Taxonomic lineageBacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phosphoribosyl)-ATP + H2O = 1-(5-phosphoribosyl)-AMP + diphosphate. HAMAP MF_01019

1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide. HAMAP MF_01019

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9. HAMAP MF_01019

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.

Subcellular location

Cytoplasm By similarity HAMAP MF_01019.

Sequence similarities

In the N-terminal section; belongs to the PRA-CH family.

In the C-terminal section; belongs to the PRA-PH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Histidine biosynthesis bifunctional protein HisIE HAMAP MF_01019
PRO_0000136410

Regions

Region1 – 118118Phosphoribosyl-AMP cyclohydrolase HAMAP MF_01019
Region119 – 218100Phosphoribosyl-ATP pyrophosphohydrolase HAMAP MF_01019

Sequences

Sequence LengthMass (Da)Tools
Q9RWD6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 2DD93167ED3848E1

FASTA21823,484
        10         20         30         40         50         60 
MTDLSELNFD PSGLIPVVTQ DARSGAVLMQ AYADRAAVER TLDTREATYY SRSRGEQWVK 

        70         80         90        100        110        120 
GQTSGHTQRV VSVHVDCDGD SLLYRVEQTG PACHTGEYSC FYRPLLEDDA PDTGLDGTLE 

       130        140        150        160        170        180 
RVYATITERL ATLPEGSYVA RLHAGGLDRV LKKISEEAGE VLLAAKNADR AELATETADL 

       190        200        210 
LFHTLFALAE VGVSPADVAA VLQGREGKSG LKGPKEVG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE000513 Genomic DNA. Translation: AAF10312.1.
PIRD75482.
RefSeqNP_294456.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RWD6.
SMRQ9RWD6. Positions 6-108.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1800250.
GenomeReviewsGene locus DR_0733 in contig AE000513_GR.
KEGGdra:DR_0733.
NMPDRfig|243230.1.peg.915.
PATRIC21629010. VBIDeiRad64572_0911.
TIGRDR_0733.

Phylogenomic databases

HOGENOMHBG294308.
OMAVMACKDD.
PhylomeDBQ9RWD6.
ProtClustDBPRK02759.

Enzyme and pathway databases

BioCycDRAD243230:DR_0733-MONOMER.

Family and domain databases

HAMAPMF_01019. HisIE.
[Tree]
InterProIPR023019. His_synth_HisIE.
IPR008179. PRib-ATP_PPHydrolase.
IPR021130. PRib-ATP_PPHydrolase-like.
IPR002496. PRib_AMP_CycHydrolase.
[Graphical view]
KOK11755.
PfamPF01502. PRA-CH. 1 hit.
PF01503. PRA-PH. 1 hit.
[Graphical view]
ProDomPD002610. PRA_CycHdrlase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR03188. Histidine_hisI. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS2_DEIRA
AccessionPrimary (citable) accession number: Q9RWD6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: May 1, 2000
Last modified: January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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