Reviewed, UniProtKB/Swiss-Prot Q9RWB4 (RL19_DEIRA)

Names and origin

Protein names

Recommended name:
    50S ribosomal protein L19

Gene names

Name:	rplS
Ordered Locus Names:	DR_0755

Organism

Deinococcus radiodurans [Complete proteome] [HAMAP]

Taxonomic identifier

1299 [NCBI]

Taxonomic lineage

Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site By similarity. Binds the 23S rRNA.
Subunit structure	Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8
Sequence similarities	Belongs to the ribosomal protein L19P family.

Ontologies

Keywords
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	3D-structure Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	translation Inferred from electronic annotation. Source: HAMAP
Cellular component	ribosome Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 166

166

50S ribosomal protein L19 HAMAP MF_00402

PRO_0000163448

Secondary structure

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166

Helix Strand Turn

Details...

Helix

18 – 20

3

Beta strand

32 – 36

5

Beta strand

48 – 50

3

Beta strand

54 – 56

3

Beta strand

65 – 69

5

Beta strand

78 – 82

5

Beta strand

88 – 94

7

Beta strand

100 – 102

3

Helix

105 – 107

3

Sequences

	Sequence		Length	Mass (Da)
	Q9RWB4-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 1DA8E740601FFAF9	FASTA	166	18,316
	10 20 30 40 50 60 MQTHIKINRG ELLRGIEQDH TRQLPDFRPG DTVRVDTKVR EGNRTRSQAF EGVVIAINGS 70 80 90 100 110 120 GSRKSFTVRK ISFGEGVERV FPFASPLVNQ VTIVERGKVR RAKLYYLREL RGKAARIKSD 130 140 150 160 RSRVMKDAAR AQQDKANASA SQAAAAQADV TVISAAPEVA PETQGE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[2]	"High resolution structure of the large ribosomal subunit from a mesophilic eubacterium." Harms J., Schluenzen F., Zarivach R., Bashan A., Gat S., Agmon I., Bartels H., Franceschi F., Yonath A. Cell 107:679-688(2001) [PubMed: 11733066] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT, PROTEIN SEQUENCE OF 1-5. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[3]	"Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria." Schluenzen F., Zarivach R., Harms J., Bashan A., Tocilj A., Albrecht R., Yonath A., Franceschi F. Nature 413:814-821(2001) [PubMed: 11677599] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.1 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH FIVE ANTIBIOTICS. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[4]	"Structural basis of the ribosomal machinery for peptide bond formation, translocation, and nascent chain progression." Bashan A., Agmon I., Zarivach R., Schluenzen F., Harms J., Berisio R., Bartels H., Franceschi F., Auerbach T., Hansen H.A., Kossoy E., Kessler M., Yonath A. Mol. Cell 11:91-102(2003) [PubMed: 12535524] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TRNA MIMICS. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[5]	"Structural basis for the antibiotic activity of ketolides and azalides." Schluenzen F., Harms J.M., Franceschi F., Hansen H.A., Bartels H., Zarivach R., Yonath A. Structure 11:329-338(2003) [PubMed: 12623020] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH MODIFIED MACROLIDE ANTIBIOTICS. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[6]	"Structural insight into the role of the ribosomal tunnel in cellular regulation." Berisio R., Schluenzen F., Harms J., Bashan A., Auerbach T., Baram D., Yonath A. Nat. Struct. Biol. 10:366-370(2003) [PubMed: 12665853] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TROLEANDOMYCIN. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[7]	"Alterations at the peptidyl transferase centre of the ribosome induced by the synergistic action of the streptogramins dalfopristin and quinupristin." Harms J.M., Schluenzen F., Fucini P., Bartels H., Yonath A. BMC Biol. 2:4-4(2004) [PubMed: 15059283] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.4 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH THE STREPTOGRAMINS QUINUPRISTIN AND DALFOPRISTIN. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
[8]	"Inhibition of peptide bond formation by pleuromutilins: the structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with tiamulin." Schluenzen F., Pyetan E., Fucini P., Yonath A., Harms J.M. Mol. Microbiol. 54:1287-1294(2004) [PubMed: 15554968] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS) OF THE 50S SUBUNIT IN COMPLEX WITH TIAMULIN. Strain: ATCC 13939 / DSM 20539 / IFO 15346 / LMG 4051 / NCIB 9279 / R1.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

AE000513 Genomic DNA. Translation: AAF10334.1.

PIR

G75478.

RefSeq

NP_294479.1.

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1NKW	X-ray	3.10	N	1-166	[»]
1NWX	X-ray	3.50	N	1-166	[»]
1NWY	X-ray	3.30	N	1-166	[»]
1PNU	X-ray	8.70	N	2-126	[»]
1PNY	X-ray	9.50	N	2-126	[»]
1SM1	X-ray	3.42	N	1-166	[»]
1XBP	X-ray	3.50	N	1-166	[»]
2ZJP	X-ray	3.70	M	1-166	[»]
2ZJQ	X-ray	3.30	M	1-166	[»]
2ZJR	X-ray	2.91	M	1-166	[»]
3CF5	X-ray	3.30	M	1-166	[»]
3DLL	X-ray	3.50	M	1-166	[»]

ModBase

Search...

Genome annotation databases

GeneID

1800020.

GenomeReviews

Gene locus DR_0755 in contig AE000513_GR.

KEGG

dra:DR_0755.

NMPDR

fig|243230.1.peg.938.

TIGR

DR_0755.

Phylogenomic databases

HOGENOM

Q9RWB4.

OMA

AVSKTER.

Enzyme and pathway databases

BioCyc

DRAD243230:DR_0755-MON.

Family and domain databases

HAMAP

MF_00402.
[Tree]

InterPro

IPR001857. Ribosomal_L19.
IPR018257. Ribosomal_L19_CS.
[Graphical view]

PANTHER

PTHR15680. Ribosomal_L19. 1 hit.

Pfam

PF01245. Ribosomal_L19. 1 hit.
[Graphical view]

PRINTS

PR00061. RIBOSOMALL19.

ProDom

PD002979. Ribosomal_L19. 1 hit.
[Graphical view] [Entries sharing at least one domain]

TIGRFAMs

TIGR01024. rplS_bact. 1 hit.

PROSITE

PS01015. RIBOSOMAL_L19. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

RL19_DEIRA

Accession

Primary (citable) accession number: Q9RWB4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	May 1, 2000
Last modified:	November 3, 2009
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)