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Q9RWB2 (CISY_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length377 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect By similarity. UniProtKB P39120

Catalytic activity

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.

Subunit structure

Homodimer By similarity. UniProtKB Q53554

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism. UniProtKB P39120

Sequence similarities

Belongs to the citrate synthase family.

Sequence caution

The sequence AAF10336.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processTricarboxylic acid cycle
   Molecular functionTransferase
   Technical termAllosteric enzyme
Complete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular carbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

tricarboxylic acid cycle

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncitrate (Si)-synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 377376Citrate synthase
PRO_0000169942

Sites

Active site2201 By similarity UniProtKB P21553
Active site2591 By similarity UniProtKB P21553
Active site3131 By similarity UniProtKB P21553

Sequences

Sequence LengthMass (Da)Tools
Q9RWB2 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 268F74D5B8EC37DA

FASTA37741,628
        10         20         30         40         50         60 
MSNIAKGLEG VLFTESKLTF INGSEGILTH LGIPIQEWAE KSTFEELSLA LLDAKLPTAE 

        70         80         90        100        110        120 
ELAKFDAELK ANRAIPDQLV GIIRDMPKGV HPMQALRTAV SYLGLLDPQA EDITPEARRA 

       130        140        150        160        170        180 
ISTRMIAQFS TIIAAINRAQ EGQDIVAPRA DLTHAGNFLY MLTGNEPTPE QARLFDIALV 

       190        200        210        220        230        240 
LHADHGMNAS TFTAIATSST LSDMYSCMVS AIGALKGPLH GGANEAVMTM LDEIGTVDKA 

       250        260        270        280        290        300 
EAYITGKLDN KEKIMGVGHR VYKYFDPRSR VLRDYAEHVA NKEGKSNYYQ ILEAIEKIIV 

       310        320        330        340        350        360 
DRMGAKGIYP NVDFYSGTVY SDLGIKKEYF TPIFALARIS GWCASVIEYS QDNRLLRPDA 

       370 
EYTGARDQHY VDIKDRQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF10336.1. Different initiation.
PIRA75479.
RefSeqNP_294481.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RWB2.
SMRQ9RWB2. Positions 4-376.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0757.

Proteomic databases

PRIDEQ9RWB2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF10336; AAF10336; DR_0757.
GeneID1798731.
KEGGdra:DR_0757.
PATRIC21629062. VBIDeiRad64572_0937.

Phylogenomic databases

eggNOGCOG0372.
HOGENOMHOG000021225.
KOK01647.
OMAVYHSLGI.
OrthoDBEOG6P8TP4.
ProtClustDBCLSK444698.

Enzyme and pathway databases

BioCycDRAD243230:GH46-779-MONOMER.
UniPathwayUPA00223; UER00717.

Family and domain databases

Gene3D1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProIPR011278. 2-MeCitrate/Citrate_synth_I.
IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERPTHR11739. PTHR11739. 1 hit.
PfamPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFPIRSF001369. Citrate_synth. 1 hit.
PRINTSPR00143. CITRTSNTHASE.
SUPFAMSSF48256. SSF48256. 1 hit.
TIGRFAMsTIGR01800. cit_synth_II. 1 hit.
PROSITEPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCISY_DEIRA
AccessionPrimary (citable) accession number: Q9RWB2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 87 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways