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Protein

DNA repair protein RecO

Gene

recO

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Involved in DNA repair and RecF pathway recombination.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi153 – 1531ZincCombined sources
Metal bindingi156 – 1561ZincCombined sources
Metal bindingi173 – 1731ZincCombined sources
Metal bindingi176 – 1761ZincCombined sources

GO - Molecular functioni

GO - Biological processi

  • DNA recombination Source: UniProtKB-HAMAP
  • double-strand break repair Source: CACAO
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repairUniRule annotationSAAS annotation

Keywords - Ligandi

Metal-bindingCombined sources, ZincCombined sources

Enzyme and pathway databases

BioCyciDRAD243230:GH46-841-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein RecOUniRule annotationSAAS annotation
Alternative name(s):
Recombination protein OUniRule annotation
Gene namesi
Name:recOUniRule annotation
Ordered Locus Names:DR_0819Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Interactioni

Protein-protein interaction databases

IntActiQ9RW50. 1 interaction.
MINTiMINT-4981197.
STRINGi243230.DR_0819.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U5KX-ray2.00A/B1-244[»]
1W3SX-ray2.40A/B1-244[»]
2V1CX-ray3.80C1-244[»]
4JCVX-ray3.34E/F2-244[»]
ProteinModelPortaliQ9RW50.
SMRiQ9RW50. Positions 2-244.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RW50.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 7570DNA_rep/recomb_RecO_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RecO family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG41084FE. Bacteria.
COG1381. LUCA.
HOGENOMiHOG000099272.
InParanoidiQ9RW50.
OMAiEWVALVM.
OrthoDBiEOG6XWV1T.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00201. RecO.
InterProiIPR022572. DNA_rep/recomb_RecO_N.
IPR012340. NA-bd_OB-fold.
IPR003717. RecO.
[Graphical view]
PfamiPF02565. RecO_C. 1 hit.
PF11967. RecO_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00613. reco. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RW50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRTANRSG IVIRRRVTPA GDIIVTLLTP QGKLKAIARG GVKGPLSSSL
60 70 80 90 100
NLFHHVGVQV YQGPHNDLAS VKQAVLEGAL PTLAEPERYA FAHLMAEFAD
110 120 130 140 150
ALFQEGEFSE QAFDLFAASL RGVAHQPDPE WVALVMSYKL LGLAGVIPQT
160 170 180 190 200
ARCARCGAPD PEHPDPLGGQ LLCSKCAALP PYPPAVLDFL RHAVRRTVRA
210 220 230 240
SFEQPVPSAD RPALWRALEK FVTVQVGGVH SWRQLVPSGV PVLS
Length:244
Mass (Da):26,343
Last modified:May 1, 2000 - v1
Checksum:iB5CC31298B0227A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10403.1.
PIRiA75472.
RefSeqiNP_294543.1. NC_001263.1.
WP_010887465.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF10403; AAF10403; DR_0819.
GeneIDi1799732.
KEGGidra:DR_0819.
PATRICi21629188. VBIDeiRad64572_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10403.1.
PIRiA75472.
RefSeqiNP_294543.1. NC_001263.1.
WP_010887465.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1U5KX-ray2.00A/B1-244[»]
1W3SX-ray2.40A/B1-244[»]
2V1CX-ray3.80C1-244[»]
4JCVX-ray3.34E/F2-244[»]
ProteinModelPortaliQ9RW50.
SMRiQ9RW50. Positions 2-244.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9RW50. 1 interaction.
MINTiMINT-4981197.
STRINGi243230.DR_0819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10403; AAF10403; DR_0819.
GeneIDi1799732.
KEGGidra:DR_0819.
PATRICi21629188. VBIDeiRad64572_1000.

Phylogenomic databases

eggNOGiENOG41084FE. Bacteria.
COG1381. LUCA.
HOGENOMiHOG000099272.
InParanoidiQ9RW50.
OMAiEWVALVM.
OrthoDBiEOG6XWV1T.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-841-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9RW50.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00201. RecO.
InterProiIPR022572. DNA_rep/recomb_RecO_N.
IPR012340. NA-bd_OB-fold.
IPR003717. RecO.
[Graphical view]
PfamiPF02565. RecO_C. 1 hit.
PF11967. RecO_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00613. reco. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.
  2. "A novel structure of DNA repair protein RecO from Deinococcus radiodurans."
    Makharashvili N., Koroleva O., Bera S., Grandgenett D.P., Korolev S.
    Structure 12:1881-1889(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC.
  3. "Crystal structure and DNA-binding analysis of RecO from Deinococcus radiodurans."
    Leiros I., Timmins J., Hall D.R., McSweeney S.
    EMBO J. 24:906-918(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
  4. "Crystal structure and mutational study of RecOR provide insight into its mode of DNA binding."
    Timmins J., Leiros I., McSweeney S.
    EMBO J. 26:3260-3271(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.80 ANGSTROMS) IN COMPLEX WITH ZINC.
  5. "An 'open' structure of the RecOR complex supports ssDNA binding within the core of the complex."
    Radzimanowski J., Dehez F., Round A., Bidon-Chanal A., McSweeney S., Timmins J.
    Nucleic Acids Res. 41:7972-7986(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.34 ANGSTROMS) OF 2-244 IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiQ9RW50_DEIRA
AccessioniPrimary (citable) accession number: Q9RW50
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.