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Q9RW01 (PUR9_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:DR_0868
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length510 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence caution

The sequence AAF10444.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 510510Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192090

Sequences

Sequence LengthMass (Da)Tools
Q9RW01 [UniParc].

Last modified June 20, 2003. Version 2.
Checksum: 668734C53416269C

FASTA51054,046
        10         20         30         40         50         60 
MTKRALISVS DKTGVVEFAA QLQQRGWELL STGGTFATLS GAGIPVRQVS DVTGFPEMLD 

        70         80         90        100        110        120 
GRVKTLHPAI HGGILARREA GHLGQLAAQD IGTIDLVCVN LYPFRETVAR GAPDPEVIEN 

       130        140        150        160        170        180 
IDIGGPAMIR SAAKNHDAVL VLVDPADYAL ALQDEVSPAE RRRLAAKAYR HTSEYDAAIT 

       190        200        210        220        230        240 
AYLSGESDEL PTQLPEHLSL DLTRTAQVRY GENPHQPGAI YRWGNARGPV IDAQVVAGKP 

       250        260        270        280        290        300 
MSFNNYADAD AAWSLCQELA AQEQGAVCVA VKHANPCGVA VAADVKTAWE RARDADTLSV 

       310        320        330        340        350        360 
FGGVVAVSQP VDFGAAQSMK GTFLEVLIAP DVTPDAVEWF AAKKPDLRVL IAGQPQGVSV 

       370        380        390        400        410        420 
LDVRPLTGGF AVQERDARPW DDLCPEVVTE RQPSEQEWAD LRFAWAVVKG ARSNAVALCK 

       430        440        450        460        470        480 
GGVTVGLGAG AVSRIWAAER AIANAGEAAQ GAVLASEAFF PFDDVVRLAA SAGVTAVLQP 

       490        500        510 
GGAKRDPEVI AACNELGISM VFTGSRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF10444.1. Different initiation.
PIRB75467.
RefSeqNP_294592.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RW01.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_0868.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF10444; AAF10444; DR_0868.
GeneID1797790.
KEGGdra:DR_0868.
PATRIC21629294. VBIDeiRad64572_1052.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycDRAD243230:GH46-891-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_DEIRA
AccessionPrimary (citable) accession number: Q9RW01
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: June 20, 2003
Last modified: February 19, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways