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Q9RVE3 (ALR_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein attributes

Sequence length351 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Sequence caution

The sequence AAF10657.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   LigandPyridoxal phosphate
   Molecular functionIsomerase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processD-alanine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionalanine racemase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

pyridoxal phosphate binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 351351Alanine racemase HAMAP-Rule MF_01201
PRO_0000114513

Sites

Active site341Proton acceptor; specific for D-alanine By similarity
Active site2481Proton acceptor; specific for L-alanine By similarity
Binding site1261Substrate By similarity
Binding site2961Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue341N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RVE3 [UniParc].

Last modified March 5, 2002. Version 2.
Checksum: F924ABD66E2FFA05

FASTA35137,193
        10         20         30         40         50         60 
MLPRAVAHIS AAALDHNLSA LAQRSGTRLL LPVKADAYGH GMELVGRLAA AHPDVWGLAV 

        70         80         90        100        110        120 
ATPQEAETLA RLDLGKPLLL LTPPAPEELG ALADLGVRLP VSTLAEVEAL PAHAQAHLKV 

       130        140        150        160        170        180 
DTGMNRLGAR PADAVAVGRA LAERGQLEGV YTHFATADEP DLSFALTQLV RFRSVLDALP 

       190        200        210        220        230        240 
PVLAHCANGG GVLSFGRIEG MSLARPGLAA YGYVPEHLRH VCALRPVMTV RARVNQLHTA 

       250        260        270        280        290        300 
YPGETVSYGA LWRAERETGV AVVGMGYADG YPRNATGRAA VLIGGERRPV LGRICMDQMM 

       310        320        330        340        350 
VDVTGLDVGV GDWAELWGEG DLSVTDVARW GDTIEYEVLT GLGSRVERRV G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF10657.1. Different initiation.
PIRH75440.
RefSeqNP_294810.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RVE3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_1086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF10657; AAF10657; DR_1086.
GeneID1800150.
KEGGdra:DR_1086.
PATRIC21629758. VBIDeiRad64572_1281.

Phylogenomic databases

eggNOGCOG0787.
HOGENOMHOG000031444.
KOK01775.
OMASVELWGD.
OrthoDBEOG6PP9NJ.
ProtClustDBCLSK444872.

Enzyme and pathway databases

BioCycDRAD243230:GH46-1112-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR_DEIRA
AccessionPrimary (citable) accession number: Q9RVE3
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: February 19, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways