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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi33 – 40ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: UniProtKB-HAMAP
  • double-strand break repair Source: CACAO
  • SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecF
Gene namesi
Name:recF
Ordered Locus Names:DR_1089
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001964131 – 359DNA replication and repair protein RecFAdd BLAST359

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1089.

Structurei

Secondary structure

1359
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 14Combined sources9
Beta strandi19 – 23Combined sources5
Beta strandi26 – 32Combined sources7
Helixi39 – 51Combined sources13
Helixi59 – 62Combined sources4
Beta strandi70 – 78Combined sources9
Beta strandi81 – 90Combined sources10
Beta strandi93 – 98Combined sources6
Beta strandi101 – 103Combined sources3
Helixi105 – 107Combined sources3
Beta strandi113 – 116Combined sources4
Turni118 – 121Combined sources4
Helixi122 – 125Combined sources4
Helixi128 – 142Combined sources15
Helixi144 – 165Combined sources22
Helixi169 – 171Combined sources3
Turni172 – 175Combined sources4
Helixi176 – 207Combined sources32
Beta strandi214 – 219Combined sources6
Turni224 – 226Combined sources3
Helixi227 – 233Combined sources7
Helixi235 – 241Combined sources7
Helixi248 – 250Combined sources3
Beta strandi252 – 257Combined sources6
Helixi262 – 265Combined sources4
Helixi268 – 290Combined sources23
Beta strandi295 – 298Combined sources4
Helixi301 – 303Combined sources3
Helixi307 – 319Combined sources13
Beta strandi320 – 329Combined sources10
Beta strandi335 – 341Combined sources7
Beta strandi344 – 347Combined sources4
Turni351 – 353Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O5VX-ray1.61A1-359[»]
ProteinModelPortaliQ9RVE0.
SMRiQ9RVE0.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RVE0.

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.Curated

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
InParanoidiQ9RVE0.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiPOG091H00U7.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF. 1 hit.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RVE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVRLSALS TLNYRNLAPG TLNFPEGVTG IYGENGAGKT NLLEAAYLAL
60 70 80 90 100
TGQTDAPRIE QLIQAGETEA YVRADLQQGG SLSIQEVGLG RGRRQLKVDG
110 120 130 140 150
VRARTGDLPR GGAVWIRPED SELVFGPPSG RRAYLDSLLS RLSARYGEQL
160 170 180 190 200
SRYERTVSQR NAALRGGEEW AMHVWDDVLL KLGTEIMLFR RRALTRLDEL
210 220 230 240 250
AREANAQLGS RKTLALTLTE STSPETYAAD LRGRRAEELA RGSTVTGPHR
260 270 280 290 300
DDLLLTLGDF PASDYASRGE GRTVALALRR AELELLREKF GEDPVLLLDD
310 320 330 340 350
FTAELDPHRR QYLLDLAASV PQAIVTGTEL APGAALTLRA QAGRFTPVAD

EEMQAEGTA
Length:359
Mass (Da):39,141
Last modified:May 1, 2000 - v1
Checksum:i9FD36A26CAFF3ECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10663.1.
PIRiA75438.
RefSeqiNP_294813.1. NC_001263.1.
WP_010887732.1. NZ_CP015081.1.

Genome annotation databases

EnsemblBacteriaiAAF10663; AAF10663; DR_1089.
GeneIDi1799966.
KEGGidra:DR_1089.
PATRICi21629766. VBIDeiRad64572_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10663.1.
PIRiA75438.
RefSeqiNP_294813.1. NC_001263.1.
WP_010887732.1. NZ_CP015081.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2O5VX-ray1.61A1-359[»]
ProteinModelPortaliQ9RVE0.
SMRiQ9RVE0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10663; AAF10663; DR_1089.
GeneIDi1799966.
KEGGidra:DR_1089.
PATRICi21629766. VBIDeiRad64572_1285.

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
InParanoidiQ9RVE0.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiPOG091H00U7.

Miscellaneous databases

EvolutionaryTraceiQ9RVE0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF. 1 hit.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRECF_DEIRA
AccessioniPrimary (citable) accession number: Q9RVE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.