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Protein

DNA replication and repair protein RecF

Gene

recF

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 408ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: UniProtKB-HAMAP
  • double-strand break repair Source: CACAO
  • SOS response Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, DNA replication, SOS response

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1115-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication and repair protein RecF
Gene namesi
Name:recF
Ordered Locus Names:DR_1089
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359DNA replication and repair protein RecFPRO_0000196413Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1089.

Structurei

Secondary structure

1
359
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 149Combined sources
Beta strandi19 – 235Combined sources
Beta strandi26 – 327Combined sources
Helixi39 – 5113Combined sources
Helixi59 – 624Combined sources
Beta strandi70 – 789Combined sources
Beta strandi81 – 9010Combined sources
Beta strandi93 – 986Combined sources
Beta strandi101 – 1033Combined sources
Helixi105 – 1073Combined sources
Beta strandi113 – 1164Combined sources
Turni118 – 1214Combined sources
Helixi122 – 1254Combined sources
Helixi128 – 14215Combined sources
Helixi144 – 16522Combined sources
Helixi169 – 1713Combined sources
Turni172 – 1754Combined sources
Helixi176 – 20732Combined sources
Beta strandi214 – 2196Combined sources
Turni224 – 2263Combined sources
Helixi227 – 2337Combined sources
Helixi235 – 2417Combined sources
Helixi248 – 2503Combined sources
Beta strandi252 – 2576Combined sources
Helixi262 – 2654Combined sources
Helixi268 – 29023Combined sources
Beta strandi295 – 2984Combined sources
Helixi301 – 3033Combined sources
Helixi307 – 31913Combined sources
Beta strandi320 – 32910Combined sources
Beta strandi335 – 3417Combined sources
Beta strandi344 – 3474Combined sources
Turni351 – 3533Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O5VX-ray1.61A1-359[»]
ProteinModelPortaliQ9RVE0.
SMRiQ9RVE0. Positions 2-359.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RVE0.

Family & Domainsi

Sequence similaritiesi

Belongs to the RecF family.Curated

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
InParanoidiQ9RVE0.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiEOG6HTP3X.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RVE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDVRLSALS TLNYRNLAPG TLNFPEGVTG IYGENGAGKT NLLEAAYLAL
60 70 80 90 100
TGQTDAPRIE QLIQAGETEA YVRADLQQGG SLSIQEVGLG RGRRQLKVDG
110 120 130 140 150
VRARTGDLPR GGAVWIRPED SELVFGPPSG RRAYLDSLLS RLSARYGEQL
160 170 180 190 200
SRYERTVSQR NAALRGGEEW AMHVWDDVLL KLGTEIMLFR RRALTRLDEL
210 220 230 240 250
AREANAQLGS RKTLALTLTE STSPETYAAD LRGRRAEELA RGSTVTGPHR
260 270 280 290 300
DDLLLTLGDF PASDYASRGE GRTVALALRR AELELLREKF GEDPVLLLDD
310 320 330 340 350
FTAELDPHRR QYLLDLAASV PQAIVTGTEL APGAALTLRA QAGRFTPVAD

EEMQAEGTA
Length:359
Mass (Da):39,141
Last modified:May 1, 2000 - v1
Checksum:i9FD36A26CAFF3ECB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10663.1.
PIRiA75438.
RefSeqiNP_294813.1. NC_001263.1.
WP_010887732.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF10663; AAF10663; DR_1089.
GeneIDi1799966.
KEGGidra:DR_1089.
PATRICi21629766. VBIDeiRad64572_1285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10663.1.
PIRiA75438.
RefSeqiNP_294813.1. NC_001263.1.
WP_010887732.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2O5VX-ray1.61A1-359[»]
ProteinModelPortaliQ9RVE0.
SMRiQ9RVE0. Positions 2-359.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10663; AAF10663; DR_1089.
GeneIDi1799966.
KEGGidra:DR_1089.
PATRICi21629766. VBIDeiRad64572_1285.

Phylogenomic databases

eggNOGiENOG4105C3X. Bacteria.
COG1195. LUCA.
HOGENOMiHOG000269561.
InParanoidiQ9RVE0.
KOiK03629.
OMAiKVQTFIT.
OrthoDBiEOG6HTP3X.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1115-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9RVE0.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_00365. RecF.
InterProiIPR001238. DNA-binding_RecF.
IPR018078. DNA-binding_RecF_CS.
IPR027417. P-loop_NTPase.
IPR003395. RecF/RecN/SMC_N.
[Graphical view]
PANTHERiPTHR32182:SF0. PTHR32182:SF0. 1 hit.
PfamiPF02463. SMC_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00611. recf. 1 hit.
PROSITEiPS00617. RECF_1. 1 hit.
PS00618. RECF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiRECF_DEIRA
AccessioniPrimary (citable) accession number: Q9RVE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 1, 2000
Last modified: May 11, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.