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Q9RV76

- ALLB_DEIRA

UniProt

Q9RV76 - ALLB_DEIRA

Protein

Allantoinase

Gene

allB

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.UniRule annotation

    Cofactori

    Binds 2 zinc ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Zinc 1UniRule annotation
    Metal bindingi62 – 621Zinc 1UniRule annotation
    Metal bindingi147 – 1471Zinc 1; via carbamate groupUniRule annotation
    Metal bindingi147 – 1471Zinc 2; via carbamate groupUniRule annotation
    Metal bindingi183 – 1831Zinc 2UniRule annotation
    Metal bindingi239 – 2391Zinc 2UniRule annotation
    Metal bindingi312 – 3121Zinc 1UniRule annotation

    GO - Molecular functioni

    1. allantoinase activity Source: UniProtKB-HAMAP
    2. cobalt ion binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: UniProtKB-HAMAP
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-1180-MONOMER.
    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
    Alternative name(s):
    Allantoin-utilizing enzymeUniRule annotation
    Gene namesi
    Name:allBUniRule annotation
    Ordered Locus Names:DR_1153
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 448448AllantoinasePRO_0000165941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei147 – 1471N6-carboxylysineUniRule annotation

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi243230.DR_1153.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RV76.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0044.
    HOGENOMiHOG000219146.
    KOiK01466.
    OMAiCSPWEGH.
    OrthoDBiEOG6KHFW6.

    Family and domain databases

    Gene3Di2.30.40.10. 1 hit.
    HAMAPiMF_01645. Hydantoinase.
    InterProiIPR017593. Allantoinase.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 2 hits.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9RV76-1 [UniParc]FASTAAdd to Basket

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    MSLDLLLRGA VLVTPEGERR ADLGIVGGQI AELTDEIATP AAQTLDVSGL    50
    HVFPGVLDDH VHLNEPGRTH WEGFETGTQA LAAGGATSFL DMPLNSSPPV 100
    LTRERFEDKA RLGEEKSLID FGLWGGLTPL NLDQLDDLAE CGVIGLKAFM 150
    SHSGLDEFPA ADDLTLYEGM RTAKRHGLVV ATHAESNEFT RRLTETARAQ 200
    GKSGVRDYLE SRPVVTELEA VQRALLFAQD TGAALHLVHV SSGAAVALAY 250
    EGKQKGIDVT IETCPHYLHF TGEDVERVGA ALKCAPPLRD PAVQEELWRE 300
    LLAGHIDTVG SDHSPAPPDM KTSEDFFSLW GGISGAQSTL NVMLEDGYAQ 350
    RGLPLEIIAA LLALNPAQRF GLPQKGRLAV GADADFALVA LGEKFTLDTL 400
    YDRWQQNPYR GQSFQGRVHA TYLRGQPVYQ NGEFTGTPRG RLLRPRSL 448
    Length:448
    Mass (Da):48,559
    Last modified:May 1, 2000 - v1
    Checksum:i3215965D0613AF86
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF10727.1.
    PIRiE75429.
    RefSeqiNP_294877.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF10727; AAF10727; DR_1153.
    GeneIDi1798402.
    KEGGidra:DR_1153.
    PATRICi21629898. VBIDeiRad64572_1350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF10727.1 .
    PIRi E75429.
    RefSeqi NP_294877.1. NC_001263.1.

    3D structure databases

    ProteinModelPortali Q9RV76.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_1153.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF10727 ; AAF10727 ; DR_1153 .
    GeneIDi 1798402.
    KEGGi dra:DR_1153.
    PATRICi 21629898. VBIDeiRad64572_1350.

    Phylogenomic databases

    eggNOGi COG0044.
    HOGENOMi HOG000219146.
    KOi K01466.
    OMAi CSPWEGH.
    OrthoDBi EOG6KHFW6.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .
    BioCyci DRAD243230:GH46-1180-MONOMER.

    Family and domain databases

    Gene3Di 2.30.40.10. 1 hit.
    HAMAPi MF_01645. Hydantoinase.
    InterProi IPR017593. Allantoinase.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 2 hits.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiALLB_DEIRA
    AccessioniPrimary (citable) accession number: Q9RV76
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3