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Protein

Allantoinase

Gene

allB

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.UniRule annotation

Catalytic activityi

(S)-allantoin + H2O = allantoate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Zinc 1UniRule annotation
Metal bindingi62 – 621Zinc 1UniRule annotation
Metal bindingi147 – 1471Zinc 1; via carbamate groupUniRule annotation
Metal bindingi147 – 1471Zinc 2; via carbamate groupUniRule annotation
Metal bindingi183 – 1831Zinc 2UniRule annotation
Metal bindingi239 – 2391Zinc 2UniRule annotation
Metal bindingi312 – 3121Zinc 1UniRule annotation

GO - Molecular functioni

  1. allantoinase activity Source: UniProtKB-HAMAP
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: UniProtKB-HAMAP
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1180-MONOMER.
UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
AllantoinaseUniRule annotation (EC:3.5.2.5UniRule annotation)
Alternative name(s):
Allantoin-utilizing enzymeUniRule annotation
Gene namesi
Name:allBUniRule annotation
Ordered Locus Names:DR_1153
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448AllantoinasePRO_0000165941Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei147 – 1471N6-carboxylysineUniRule annotation

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.UniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi243230.DR_1153.

Structurei

3D structure databases

ProteinModelPortaliQ9RV76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
InParanoidiQ9RV76.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9RV76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLDLLLRGA VLVTPEGERR ADLGIVGGQI AELTDEIATP AAQTLDVSGL
60 70 80 90 100
HVFPGVLDDH VHLNEPGRTH WEGFETGTQA LAAGGATSFL DMPLNSSPPV
110 120 130 140 150
LTRERFEDKA RLGEEKSLID FGLWGGLTPL NLDQLDDLAE CGVIGLKAFM
160 170 180 190 200
SHSGLDEFPA ADDLTLYEGM RTAKRHGLVV ATHAESNEFT RRLTETARAQ
210 220 230 240 250
GKSGVRDYLE SRPVVTELEA VQRALLFAQD TGAALHLVHV SSGAAVALAY
260 270 280 290 300
EGKQKGIDVT IETCPHYLHF TGEDVERVGA ALKCAPPLRD PAVQEELWRE
310 320 330 340 350
LLAGHIDTVG SDHSPAPPDM KTSEDFFSLW GGISGAQSTL NVMLEDGYAQ
360 370 380 390 400
RGLPLEIIAA LLALNPAQRF GLPQKGRLAV GADADFALVA LGEKFTLDTL
410 420 430 440
YDRWQQNPYR GQSFQGRVHA TYLRGQPVYQ NGEFTGTPRG RLLRPRSL
Length:448
Mass (Da):48,559
Last modified:May 1, 2000 - v1
Checksum:i3215965D0613AF86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10727.1.
PIRiE75429.
RefSeqiNP_294877.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF10727; AAF10727; DR_1153.
GeneIDi1798402.
KEGGidra:DR_1153.
PATRICi21629898. VBIDeiRad64572_1350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10727.1.
PIRiE75429.
RefSeqiNP_294877.1. NC_001263.1.

3D structure databases

ProteinModelPortaliQ9RV76.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10727; AAF10727; DR_1153.
GeneIDi1798402.
KEGGidra:DR_1153.
PATRICi21629898. VBIDeiRad64572_1350.

Phylogenomic databases

eggNOGiCOG0044.
HOGENOMiHOG000219146.
InParanoidiQ9RV76.
KOiK01466.
OMAiHAEMIPP.
OrthoDBiEOG6KHFW6.

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.
BioCyciDRAD243230:GH46-1180-MONOMER.

Family and domain databases

Gene3Di2.30.40.10. 1 hit.
HAMAPiMF_01645. Hydantoinase.
InterProiIPR017593. Allantoinase.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 2 hits.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiALLB_DEIRA
AccessioniPrimary (citable) accession number: Q9RV76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.