Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27ManganeseBy similarity1
Metal bindingi81ManganeseBy similarity1
Metal bindingi173ManganeseBy similarity1
Metal bindingi177ManganeseBy similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: CACAO
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BRENDAi1.15.1.1. 1856.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Alternative name(s):
MnSOD
Gene namesi
Name:sodA
Ordered Locus Names:DR_1279
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
Proteomesi
  • UP000002524 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001600292 – 211Superoxide dismutase [Mn]Add BLAST210

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243230.DR_1279.

Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni12 – 18Combined sources7
Helixi21 – 29Combined sources9
Helixi31 – 43Combined sources13
Turni47 – 50Combined sources4
Helixi53 – 56Combined sources4
Turni60 – 62Combined sources3
Helixi65 – 67Combined sources3
Helixi68 – 86Combined sources19
Helixi102 – 112Combined sources11
Helixi115 – 128Combined sources14
Beta strandi131 – 140Combined sources10
Beta strandi143 – 150Combined sources8
Helixi155 – 157Combined sources3
Helixi159 – 162Combined sources4
Beta strandi166 – 173Combined sources8
Helixi176 – 178Combined sources3
Helixi180 – 183Combined sources4
Helixi187 – 194Combined sources8
Helixi195 – 197Combined sources3
Helixi200 – 210Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y67X-ray1.85A/B/C/D2-211[»]
2AW9X-ray2.70A/B2-211[»]
2CDYX-ray2.00A/B/C/D2-211[»]
2CE4X-ray2.20A/B2-211[»]
3KKYX-ray1.80A/B1-211[»]
ProteinModelPortaliQ9RUV2.
SMRiQ9RUV2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RUV2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiQ9RUV2.
KOiK04564.
OMAiINQGGGH.
OrthoDBiPOG091H03Q7.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RUV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYTLPQLPY AYDALEPHID ARTMEIHHTK HHQTYVDNAN KALEGTEFAD
60 70 80 90 100
LPVEQLIQQL DRVPADKKGA LRNNAGGHAN HSMFWQIMGQ GQGQNGANQP
110 120 130 140 150
SGELLDAINS AFGSFDAFKQ KFEDAAKTRF GSGWAWLVVK DGKLDVVSTA
160 170 180 190 200
NQDNPLMGEA IAGVSGTPIL GVDVWEHAYY LNYQNRRPDY LAAFWNVVNW
210
DEVSKRYAAA K
Length:211
Mass (Da):23,478
Last modified:January 23, 2007 - v3
Checksum:iA71F22F516A1897E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10851.1.
PIRiB75415.
RefSeqiNP_295003.1. NC_001263.1.
WP_010887922.1. NZ_CP015081.1.

Genome annotation databases

EnsemblBacteriaiAAF10851; AAF10851; DR_1279.
GeneIDi1797407.
KEGGidra:DR_1279.
PATRICi21630152. VBIDeiRad64572_1475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10851.1.
PIRiB75415.
RefSeqiNP_295003.1. NC_001263.1.
WP_010887922.1. NZ_CP015081.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y67X-ray1.85A/B/C/D2-211[»]
2AW9X-ray2.70A/B2-211[»]
2CDYX-ray2.00A/B/C/D2-211[»]
2CE4X-ray2.20A/B2-211[»]
3KKYX-ray1.80A/B1-211[»]
ProteinModelPortaliQ9RUV2.
SMRiQ9RUV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10851; AAF10851; DR_1279.
GeneIDi1797407.
KEGGidra:DR_1279.
PATRICi21630152. VBIDeiRad64572_1475.

Phylogenomic databases

eggNOGiENOG4105CK4. Bacteria.
COG0605. LUCA.
HOGENOMiHOG000013583.
InParanoidiQ9RUV2.
KOiK04564.
OMAiINQGGGH.
OrthoDBiPOG091H03Q7.

Enzyme and pathway databases

BRENDAi1.15.1.1. 1856.

Miscellaneous databases

EvolutionaryTraceiQ9RUV2.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSODM_DEIRA
AccessioniPrimary (citable) accession number: Q9RUV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.