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Protein

Superoxide dismutase [Mn]

Gene

sodA

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271ManganeseBy similarity
Metal bindingi81 – 811ManganeseBy similarity
Metal bindingi173 – 1731ManganeseBy similarity
Metal bindingi177 – 1771ManganeseBy similarity

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • superoxide dismutase activity Source: CACAO

GO - Biological processi

  • removal of superoxide radicals Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1308-MONOMER.
BRENDAi1.15.1.1. 1856.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] (EC:1.15.1.1)
Alternative name(s):
MnSOD
Gene namesi
Name:sodA
Ordered Locus Names:DR_1279
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 211210Superoxide dismutase [Mn]PRO_0000160029Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243230.DR_1279.

Structurei

Secondary structure

1
211
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni12 – 187Combined sources
Helixi21 – 299Combined sources
Helixi31 – 4313Combined sources
Turni47 – 504Combined sources
Helixi53 – 564Combined sources
Turni60 – 623Combined sources
Helixi65 – 673Combined sources
Helixi68 – 8619Combined sources
Helixi102 – 11211Combined sources
Helixi115 – 12814Combined sources
Beta strandi131 – 14010Combined sources
Beta strandi143 – 1508Combined sources
Helixi155 – 1573Combined sources
Helixi159 – 1624Combined sources
Beta strandi166 – 1738Combined sources
Helixi176 – 1783Combined sources
Helixi180 – 1834Combined sources
Helixi187 – 1948Combined sources
Helixi195 – 1973Combined sources
Helixi200 – 21011Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y67X-ray1.85A/B/C/D2-211[»]
2AW9X-ray2.70A/B2-211[»]
2CDYX-ray2.00A/B/C/D2-211[»]
2CE4X-ray2.20A/B2-211[»]
3KKYX-ray1.80A/B1-211[»]
ProteinModelPortaliQ9RUV2.
SMRiQ9RUV2. Positions 2-211.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9RUV2.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
InParanoidiQ9RUV2.
KOiK04564.
OMAiMIMSYTL.
OrthoDBiEOG63NMNT.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RUV2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYTLPQLPY AYDALEPHID ARTMEIHHTK HHQTYVDNAN KALEGTEFAD
60 70 80 90 100
LPVEQLIQQL DRVPADKKGA LRNNAGGHAN HSMFWQIMGQ GQGQNGANQP
110 120 130 140 150
SGELLDAINS AFGSFDAFKQ KFEDAAKTRF GSGWAWLVVK DGKLDVVSTA
160 170 180 190 200
NQDNPLMGEA IAGVSGTPIL GVDVWEHAYY LNYQNRRPDY LAAFWNVVNW
210
DEVSKRYAAA K
Length:211
Mass (Da):23,478
Last modified:January 23, 2007 - v3
Checksum:iA71F22F516A1897E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10851.1.
PIRiB75415.
RefSeqiNP_295003.1. NC_001263.1.
WP_010887922.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF10851; AAF10851; DR_1279.
GeneIDi1797407.
KEGGidra:DR_1279.
PATRICi21630152. VBIDeiRad64572_1475.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF10851.1.
PIRiB75415.
RefSeqiNP_295003.1. NC_001263.1.
WP_010887922.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y67X-ray1.85A/B/C/D2-211[»]
2AW9X-ray2.70A/B2-211[»]
2CDYX-ray2.00A/B/C/D2-211[»]
2CE4X-ray2.20A/B2-211[»]
3KKYX-ray1.80A/B1-211[»]
ProteinModelPortaliQ9RUV2.
SMRiQ9RUV2. Positions 2-211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF10851; AAF10851; DR_1279.
GeneIDi1797407.
KEGGidra:DR_1279.
PATRICi21630152. VBIDeiRad64572_1475.

Phylogenomic databases

eggNOGiCOG0605.
HOGENOMiHOG000013583.
InParanoidiQ9RUV2.
KOiK04564.
OMAiMIMSYTL.
OrthoDBiEOG63NMNT.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1308-MONOMER.
BRENDAi1.15.1.1. 1856.

Miscellaneous databases

EvolutionaryTraceiQ9RUV2.

Family and domain databases

InterProiIPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
[Graphical view]
PANTHERiPTHR11404. PTHR11404. 1 hit.
PfamiPF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiPS00088. SOD_MN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. Joshi B.S., Apte S.K., Schmid R., Altendorf K.
    Submitted (APR-2003) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-13.
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiSODM_DEIRA
AccessioniPrimary (citable) accession number: Q9RUV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 27, 2003
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 104 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.