Q9RUD2 (KPRS_DEIRA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 75.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Probable ribose-phosphate pyrophosphokinase Short name=RPPK EC=2.7.6.1 Alternative name(s): Phosphoribosyl pyrophosphate synthase Short name=P-Rib-PP synthase Short name=PRPP synthase | ||||
| Gene names |
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| Organism | Deinococcus radiodurans | ||||
| Taxonomic identifier | 1299 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus |
Protein attributes
| Sequence length | 320 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00583_B |
| Cofactor | Binds 1 magnesium ion per subunit By similarity. HAMAP MF_00583_B |
| Pathway | Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP MF_00583_B |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00583_B. |
| Sequence similarities | Belongs to the ribose-phosphate pyrophosphokinase family. |
| Caution | This protein has lost two of the potential magnesium binding sites found in 5-phosphoribose 1-diphosphate synthases. |
| Sequence caution | The sequence AAF11025.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Magnesium Metal-binding Nucleotide-binding |
| Molecular function | Kinase Transferase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | nucleoside metabolic process Inferred from electronic annotation. Source: InterPro nucleotide biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activityInferred from electronic annotation. Source: UniProtKB-KW magnesium ion bindingInferred from electronic annotation. Source: InterPro ribose phosphate diphosphokinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 320 | 320 | Probable ribose-phosphate pyrophosphokinase HAMAP MF_00583_B | PRO_0000141133 | |||||
Regions | |||||||||
| Region | 217 – 230 | 14 | Binding of phosphoribosylpyrophosphate Potential | ||||||
Sites | |||||||||
| Metal binding | 134 | 1 | Magnesium Potential | ||||||
| Metal binding | 147 | 1 | Magnesium Potential | ||||||
Sequences
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References
| [1] | "Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. Fraser C.M.Science 286:1571-1577(1999) [PubMed: 10567266] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE000513 Genomic DNA. Translation: AAF11025.1. Different initiation. |
| PIR | B75393. |
| RefSeq | NP_295179.1. NC_001263.1. |
3D structure databases | |
| ProteinModelPortal | Q9RUD2. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1797294. |
| GenomeReviews | Gene locus DR_1456 in contig AE000513_GR. |
| KEGG | dra:DR_1456. |
| NMPDR | fig|243230.1.peg.1638. |
| PATRIC | 21630515. VBIDeiRad64572_1655. |
| TIGR | DR_1456. |
Phylogenomic databases | |
| HOGENOM | HBG519284. |
| OMA | NDCLEVQ. |
| PhylomeDB | Q9RUD2. |
| ProtClustDB | CLSK445074. |
Enzyme and pathway databases | |
| BioCyc | DRAD243230:DR_1456-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00583_B. RibP_PPkinase_B. [Tree] |
| InterPro | IPR000836. PRibTrfase. IPR005946. Rib-P_diPkinase. [Graphical view] |
| KO | K00948. |
| Pfam | PF00156. Pribosyltran. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01251. RibP_PPkin. 1 hit. |
| PROSITE | PS00114. PRPP_SYNTHASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | KPRS_DEIRA | ||||||||
| Accession | Primary (citable) accession number: Q9RUD2 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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