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Q9RU54

- Q9RU54_DEIRA

UniProt

Q9RU54 - Q9RU54_DEIRA

Protein

Isocitrate dehydrogenase [NADP]

Gene

DR_1540

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation
    Binds 1 magnesium or manganese ion per subunit By similarity.

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-1570-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:DR_1540Imported
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    Interactioni

    Protein-protein interaction databases

    STRINGi243230.DR_1540.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RU54.
    SMRiQ9RU54. Positions 15-427.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiCLRPIRY.
    OrthoDBiEOG6SNDTP.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RU54-1 [UniParc]FASTAAdd to Basket

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    MVGRPAGVGV EWASMSKHIK VPEQGEKITM QNGKLTVPNR PIIPFVEGDG    50
    TGPDIWAASV RVFDAAVEKA YGSERKLEWM EVYAGEKSLE VYGANEWLPQ 100
    ETLTAFRDYL FGIKGPLTTP VGTGIRSINV ALRQELDLYA CVRPVQYFNG 150
    VPSPVKRPED IDMVIFRENT EDIYAGIEWK AGTDEAEKVR GFLMREMNVT 200
    KIRFPDTSSF GVKPVSKEGT ERLVRAAIEY AIENGRKSVS LVHKGNIMKF 250
    TEGGFRDWGY ELAKREFGAV EIDGGPWCQL PNGIVIKDVI ADNFLQQILL 300
    RPTEYDVIAT LNLNGDYISD ALAAQVGGIG IAPGANINYV TGHAIFEATH 350
    GTAPKYAGKN VINPSSVILS GEMMLRYMGW TEAADLILKG LDATIQQRVV 400
    TYDFARGMDD ATEVKTSEFA DKIIENMRNA 430
    Length:430
    Mass (Da):47,471
    Last modified:May 1, 2000 - v1
    Checksum:iE2B1D925B75E4E8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11104.1.
    PIRiD75382.
    RefSeqiNP_295263.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11104; AAF11104; DR_1540.
    GeneIDi1798353.
    KEGGidra:DR_1540.
    PATRICi21630694. VBIDeiRad64572_1743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11104.1 .
    PIRi D75382.
    RefSeqi NP_295263.1. NC_001263.1.

    3D structure databases

    ProteinModelPortali Q9RU54.
    SMRi Q9RU54. Positions 15-427.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_1540.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11104 ; AAF11104 ; DR_1540 .
    GeneIDi 1798353.
    KEGGi dra:DR_1540.
    PATRICi 21630694. VBIDeiRad64572_1743.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi CLRPIRY.
    OrthoDBi EOG6SNDTP.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-1570-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.

    Entry informationi

    Entry nameiQ9RU54_DEIRA
    AccessioniPrimary (citable) accession number: Q9RU54
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3