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Protein

Isocitrate dehydrogenase [NADP]

Gene

DR_1540

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1570-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:DR_1540Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1540.

Structurei

3D structure databases

ProteinModelPortaliQ9RU54.
SMRiQ9RU54. Positions 15-427.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
InParanoidiQ9RU54.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RU54-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVGRPAGVGV EWASMSKHIK VPEQGEKITM QNGKLTVPNR PIIPFVEGDG
60 70 80 90 100
TGPDIWAASV RVFDAAVEKA YGSERKLEWM EVYAGEKSLE VYGANEWLPQ
110 120 130 140 150
ETLTAFRDYL FGIKGPLTTP VGTGIRSINV ALRQELDLYA CVRPVQYFNG
160 170 180 190 200
VPSPVKRPED IDMVIFRENT EDIYAGIEWK AGTDEAEKVR GFLMREMNVT
210 220 230 240 250
KIRFPDTSSF GVKPVSKEGT ERLVRAAIEY AIENGRKSVS LVHKGNIMKF
260 270 280 290 300
TEGGFRDWGY ELAKREFGAV EIDGGPWCQL PNGIVIKDVI ADNFLQQILL
310 320 330 340 350
RPTEYDVIAT LNLNGDYISD ALAAQVGGIG IAPGANINYV TGHAIFEATH
360 370 380 390 400
GTAPKYAGKN VINPSSVILS GEMMLRYMGW TEAADLILKG LDATIQQRVV
410 420 430
TYDFARGMDD ATEVKTSEFA DKIIENMRNA
Length:430
Mass (Da):47,471
Last modified:May 1, 2000 - v1
Checksum:iE2B1D925B75E4E8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11104.1.
PIRiD75382.
RefSeqiNP_295263.1. NC_001263.1.
WP_010888179.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11104; AAF11104; DR_1540.
GeneIDi1798353.
KEGGidra:DR_1540.
PATRICi21630694. VBIDeiRad64572_1743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11104.1.
PIRiD75382.
RefSeqiNP_295263.1. NC_001263.1.
WP_010888179.1. NC_001263.1.

3D structure databases

ProteinModelPortaliQ9RU54.
SMRiQ9RU54. Positions 15-427.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1540.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11104; AAF11104; DR_1540.
GeneIDi1798353.
KEGGidra:DR_1540.
PATRICi21630694. VBIDeiRad64572_1743.

Phylogenomic databases

HOGENOMiHOG000021113.
InParanoidiQ9RU54.
KOiK00031.
OMAiFRDWGYE.
OrthoDBiEOG6SNDTP.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1570-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.

Entry informationi

Entry nameiQ9RU54_DEIRA
AccessioniPrimary (citable) accession number: Q9RU54
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 4, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.