Q9RU54 (Q9RU54_DEIRA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Isocitrate dehydrogenase [NADP] RuleBase RU004446
EC=1.1.1.42 RuleBase RU004446

Gene names

Ordered Locus Names:

DR_1540 EMBL AAF11104.1

Organism

Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP] EMBL AAF11104.1

Taxonomic identifier

243230 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Deinococcus-Thermus › Deinococci › Deinococcales › Deinococcaceae › Deinococcus › Deinococcus radiodurans

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. RuleBase RU004446
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity. RuleBase RU004446
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443

Ontologies

Keywords
Biological process	Glyoxylate bypass RuleBase RU004446 Tricarboxylic acid cycle RuleBase RU004446
Ligand	Manganese RuleBase RU004446 Metal-binding RuleBase RU004446 NADP RuleBase RU004446
Molecular function	Oxidoreductase RuleBase RU004444
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	NAD binding Inferred from electronic annotation. Source: InterPro isocitrate dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9RU54 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: E2B1D925B75E4E8F	FASTA	430	47,471
	10 20 30 40 50 60 MVGRPAGVGV EWASMSKHIK VPEQGEKITM QNGKLTVPNR PIIPFVEGDG TGPDIWAASV 70 80 90 100 110 120 RVFDAAVEKA YGSERKLEWM EVYAGEKSLE VYGANEWLPQ ETLTAFRDYL FGIKGPLTTP 130 140 150 160 170 180 VGTGIRSINV ALRQELDLYA CVRPVQYFNG VPSPVKRPED IDMVIFRENT EDIYAGIEWK 190 200 210 220 230 240 AGTDEAEKVR GFLMREMNVT KIRFPDTSSF GVKPVSKEGT ERLVRAAIEY AIENGRKSVS 250 260 270 280 290 300 LVHKGNIMKF TEGGFRDWGY ELAKREFGAV EIDGGPWCQL PNGIVIKDVI ADNFLQQILL 310 320 330 340 350 360 RPTEYDVIAT LNLNGDYISD ALAAQVGGIG IAPGANINYV TGHAIFEATH GTAPKYAGKN 370 380 390 400 410 420 VINPSSVILS GEMMLRYMGW TEAADLILKG LDATIQQRVV TYDFARGMDD ATEVKTSEFA 430 DKIIENMRNA

References

[1]

"Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1." White O., Eisen J.A., Heidelberg J.F., Hickey E.K., Peterson J.D., Dodson R.J., Haft D.H., Gwinn M.L., Nelson W.C., Richardson D.L., Moffat K.S., Qin H., Jiang L., Pamphile W., Crosby M., Shen M., Vamathevan J.J., Lam P. , McDonald L.A., Utterback T.R., Zalewski C., Makarova K.S., Aravind L., Daly M.J., Minton K.W., Fleischmann R.D., Ketchum K.A., Nelson K.E., Salzberg S.L., Smith H.O., Venter J.C., Fraser C.M. Science 286:1571-1577(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE000513 Genomic DNA. Translation: AAF11104.1.
PIR	D75382.
RefSeq	NP_295263.1. NC_001263.1.
3D structure databases
ProteinModelPortal	Q9RU54.
SMR	Q9RU54. Positions 15-427.
ModBase	Search...
Protein-protein interaction databases
STRING	243230.DR_1540.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAF11104; AAF11104; DR_1540.
GeneID	1798353.
KEGG	dra:DR_1540.
PATRIC	21630694. VBIDeiRad64572_1743.
Phylogenomic databases
HOGENOM	HOG000021113.
KO	K00031.
OMA	FRDWGYE.
ProtClustDB	CLSK445123.
Enzyme and pathway databases
BioCyc	DRAD243230:GH46-1570-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR004439. Isocitrate_DH_NADP_dimer_prok. IPR024084. IsoPropMal-DH-like_dom. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR00183. prok_nadp_idh. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9RU54_DEIRA

Accession

Primary (citable) accession number: Q9RU54

Entry history

Integrated into UniProtKB/TrEMBL:	May 1, 2000
Last sequence update:	May 1, 2000
Last modified:	May 29, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)