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Q9RU48

- SODC_DEIRA

UniProt

Q9RU48 - SODC_DEIRA

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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationCuratedNote: Binds 1 copper ion per subunit.Curated
  • Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Copper; catalyticBy similarity
Metal bindingi71 – 711Copper; catalyticBy similarity
Metal bindingi95 – 951Copper; catalyticBy similarity
Metal bindingi95 – 951Zinc; structuralBy similarity
Metal bindingi104 – 1041Zinc; structuralBy similarity
Metal bindingi115 – 1151Zinc; structuralBy similarity
Metal bindingi118 – 1181Zinc; structuralBy similarity

GO - Molecular functioni

  1. copper ion binding Source: RefGenome
  2. superoxide dismutase activity Source: RefGenome
  3. zinc ion binding Source: RefGenome

GO - Biological processi

  1. removal of superoxide radicals Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
Ordered Locus Names:DR_1546
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

Subcellular locationi

Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

  1. periplasmic space Source: RefGenome
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919PROSITE-ProRule annotationAdd
BLAST
Chaini20 – 182163Superoxide dismutase [Cu-Zn]PRO_0000032841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation
Disulfide bondi76 ↔ 175By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9RU48.

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1546.

Structurei

3D structure databases

ProteinModelPortaliQ9RU48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
InParanoidiQ9RU48.
KOiK04565.
OMAiEIEVKLH.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RU48-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFRTLTVVPL LALGLSLSAC ADLGQPTVRA DLLDQTGKVT GTATFSPSPI
60 70 80 90 100
GTRVSIEVSG LKAGPHGLHI HENPNCNPGP DAQGQTIPFG AAGGHFDPGA
110 120 130 140 150
SHNHDGPHAR NDQGHGGDLP MITVGEDGKG RLNFDTNRLK MTGPTGVLGR
160 170 180
SIVIHADADD YQTNPAGNSG GRERCGVFQA IN
Length:182
Mass (Da):18,787
Last modified:May 1, 2000 - v1
Checksum:i96749572F393CA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11107.1.
PIRiB75383.
RefSeqiNP_295269.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11107; AAF11107; DR_1546.
GeneIDi1797544.
KEGGidra:DR_1546.
PATRICi21630704. VBIDeiRad64572_1748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11107.1 .
PIRi B75383.
RefSeqi NP_295269.1. NC_001263.1.

3D structure databases

ProteinModelPortali Q9RU48.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_1546.

Proteomic databases

PRIDEi Q9RU48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11107 ; AAF11107 ; DR_1546 .
GeneIDi 1797544.
KEGGi dra:DR_1546.
PATRICi 21630704. VBIDeiRad64572_1748.

Phylogenomic databases

eggNOGi COG2032.
HOGENOMi HOG000263448.
InParanoidi Q9RU48.
KOi K04565.
OMAi EIEVKLH.
OrthoDBi EOG6K13RS.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-1576-MONOMER.

Family and domain databases

Gene3Di 2.60.40.200. 1 hit.
InterProi IPR001424. SOD_Cu_Zn_dom.
[Graphical view ]
Pfami PF00080. Sod_Cu. 1 hit.
[Graphical view ]
SUPFAMi SSF49329. SSF49329. 1 hit.
PROSITEi PS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiSODC_DEIRA
AccessioniPrimary (citable) accession number: Q9RU48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the last conserved histidine that binds copper.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3