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Protein

Superoxide dismutase [Cu-Zn]

Gene

sodC

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Protein has several cofactor binding sites:
  • Cu cationCuratedNote: Binds 1 copper ion per subunit.Curated
  • Zn2+CuratedNote: Binds 1 zinc ion per subunit.Curated

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Copper; catalyticBy similarity
Metal bindingi71 – 711Copper; catalyticBy similarity
Metal bindingi95 – 951Copper; catalyticBy similarity
Metal bindingi95 – 951Zinc; structuralBy similarity
Metal bindingi104 – 1041Zinc; structuralBy similarity
Metal bindingi115 – 1151Zinc; structuralBy similarity
Metal bindingi118 – 1181Zinc; structuralBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Oxidoreductase

Keywords - Ligandi

Copper, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1576-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn] (EC:1.15.1.1)
Gene namesi
Name:sodC
Ordered Locus Names:DR_1546
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524 Componenti: Chromosome I

Subcellular locationi

  • Cell membrane PROSITE-ProRule annotation; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919PROSITE-ProRule annotationAdd
BLAST
Chaini20 – 182163Superoxide dismutase [Cu-Zn]PRO_0000032841Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi20 – 201N-palmitoyl cysteinePROSITE-ProRule annotation
Lipidationi20 – 201S-diacylglycerol cysteinePROSITE-ProRule annotation
Disulfide bondi76 ↔ 175By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ9RU48.

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1546.

Structurei

3D structure databases

ProteinModelPortaliQ9RU48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
InParanoidiQ9RU48.
KOiK04565.
OMAiKVWGSIT.
OrthoDBiEOG6K13RS.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9RU48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFRTLTVVPL LALGLSLSAC ADLGQPTVRA DLLDQTGKVT GTATFSPSPI
60 70 80 90 100
GTRVSIEVSG LKAGPHGLHI HENPNCNPGP DAQGQTIPFG AAGGHFDPGA
110 120 130 140 150
SHNHDGPHAR NDQGHGGDLP MITVGEDGKG RLNFDTNRLK MTGPTGVLGR
160 170 180
SIVIHADADD YQTNPAGNSG GRERCGVFQA IN
Length:182
Mass (Da):18,787
Last modified:May 1, 2000 - v1
Checksum:i96749572F393CA1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11107.1.
PIRiB75383.
RefSeqiNP_295269.1. NC_001263.1.
WP_010888185.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11107; AAF11107; DR_1546.
GeneIDi1797544.
KEGGidra:DR_1546.
PATRICi21630704. VBIDeiRad64572_1748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE000513 Genomic DNA. Translation: AAF11107.1.
PIRiB75383.
RefSeqiNP_295269.1. NC_001263.1.
WP_010888185.1. NC_001263.1.

3D structure databases

ProteinModelPortaliQ9RU48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243230.DR_1546.

Proteomic databases

PRIDEiQ9RU48.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF11107; AAF11107; DR_1546.
GeneIDi1797544.
KEGGidra:DR_1546.
PATRICi21630704. VBIDeiRad64572_1748.

Phylogenomic databases

eggNOGiCOG2032.
HOGENOMiHOG000263448.
InParanoidiQ9RU48.
KOiK04565.
OMAiKVWGSIT.
OrthoDBiEOG6K13RS.

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1576-MONOMER.

Family and domain databases

Gene3Di2.60.40.200. 1 hit.
InterProiIPR001424. SOD_Cu_Zn_dom.
[Graphical view]
PfamiPF00080. Sod_Cu. 1 hit.
[Graphical view]
SUPFAMiSSF49329. SSF49329. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

Entry informationi

Entry nameiSODC_DEIRA
AccessioniPrimary (citable) accession number: Q9RU48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

Lacks the last conserved histidine that binds copper.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.