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Q9RTX5

- Q9RTX5_DEIRA

UniProt

Q9RTX5 - Q9RTX5_DEIRA

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Protein
Branched-chain-amino-acid aminotransferase
Gene
DR_1626
Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.
L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. L-isoleucine transaminase activity Source: UniProtKB-EC
  2. L-leucine transaminase activity Source: UniProtKB-EC
  3. L-valine transaminase activity Source: UniProtKB-EC

GO - Biological processi

  1. branched-chain amino acid biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

AminotransferaseUniRule annotationImported, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotation

Enzyme and pathway databases

BioCyciDRAD243230:GH46-1656-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:DR_1626Imported
OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
Taxonomic identifieri243230 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000002524: Chromosome I

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei202 – 2021N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi243230.DR_1626.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3UYYX-ray2.50A/B1-358[»]
3UZBX-ray3.00A/B/C/D1-358[»]
3UZOX-ray2.00A/B1-358[»]
ProteinModelPortaliQ9RTX5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000276704.
KOiK00826.
OMAiVKPVSVW.
OrthoDBiEOG67MF3R.

Family and domain databases

InterProiIPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005786. B_amino_transII.
[Graphical view]
PANTHERiPTHR11825. PTHR11825. 1 hit.
PfamiPF01063. Aminotran_4. 1 hit.
[Graphical view]
PIRSFiPIRSF006468. BCAT1. 1 hit.
SUPFAMiSSF56752. SSF56752. 1 hit.
TIGRFAMsiTIGR01123. ilvE_II. 1 hit.
PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9RTX5-1 [UniParc]FASTAAdd to Basket

« Hide

MRLTILGMTA HDSRPEQAKK LADIDWSTLG FSYIRTDLRY LAHWKDGEWD    50
AGTLTEDNQI HLAEGSTALH YGQQCFEGLK AYRCADGSIN LFRPDQNAAR 100
MRMSCRRLLM PELSDEQFID ACLQVVRANE HFLPPYGTGG SLYLRPFVIG 150
VGDNIGVRTA PEFIFSVFCV PVGPYFKGGL TPTNFITSDY DRAAPHGTGA 200
AKVGGNYAAS LLPGYEAKKR DFADVIYLDP ATHTTIEEAG AANFFAITQD 250
GQKFVTPQSP SILPSITKYS LLWLAEHRLG LEVEEGDIRI DELGKFSEAG 300
ACGTAAVITP IGGIQHGDDF HVFYSESEPG PVTRRLYDEL VGIQYGDKEA 350
PEGWIVKV 358
Length:358
Mass (Da):39,423
Last modified:May 1, 2000 - v1
Checksum:i30DB1E8C80ABBA99
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11184.1.
PIRiC75375.
RefSeqiNP_295349.1. NC_001263.1.

Genome annotation databases

EnsemblBacteriaiAAF11184; AAF11184; DR_1626.
GeneIDi1797839.
KEGGidra:DR_1626.
PATRICi21630872. VBIDeiRad64572_1832.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE000513 Genomic DNA. Translation: AAF11184.1 .
PIRi C75375.
RefSeqi NP_295349.1. NC_001263.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3UYY X-ray 2.50 A/B 1-358 [» ]
3UZB X-ray 3.00 A/B/C/D 1-358 [» ]
3UZO X-ray 2.00 A/B 1-358 [» ]
ProteinModelPortali Q9RTX5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243230.DR_1626.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF11184 ; AAF11184 ; DR_1626 .
GeneIDi 1797839.
KEGGi dra:DR_1626.
PATRICi 21630872. VBIDeiRad64572_1832.

Phylogenomic databases

HOGENOMi HOG000276704.
KOi K00826.
OMAi VKPVSVW.
OrthoDBi EOG67MF3R.

Enzyme and pathway databases

BioCyci DRAD243230:GH46-1656-MONOMER.

Family and domain databases

InterProi IPR001544. Aminotrans_IV.
IPR018300. Aminotrans_IV_CS.
IPR005786. B_amino_transII.
[Graphical view ]
PANTHERi PTHR11825. PTHR11825. 1 hit.
Pfami PF01063. Aminotran_4. 1 hit.
[Graphical view ]
PIRSFi PIRSF006468. BCAT1. 1 hit.
SUPFAMi SSF56752. SSF56752. 1 hit.
TIGRFAMsi TIGR01123. ilvE_II. 1 hit.
PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.
  2. "Crystal structures of complexes of the branched-chain aminotransferase from Deinococcus radiodurans with ?-ketoisocaproate and L-glutamate suggest the radiation resistance of this enzyme for catalysis."
    Chen C.D., Lin C.H., Chuankhayan P., Huang Y.C., Hsieh Y.C., Huang T.F., Guan H.H., Liu M.Y., Chang W.C., Chen C.J.
    J. Bacteriol. 194:6206-6216(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).

Entry informationi

Entry nameiQ9RTX5_DEIRA
AccessioniPrimary (citable) accession number: Q9RTX5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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