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Q9RTX5

- Q9RTX5_DEIRA

UniProt

Q9RTX5 - Q9RTX5_DEIRA

Protein

Branched-chain-amino-acid aminotransferase

Gene

DR_1626

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate.UniRule annotation
    L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate.
    L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei100 – 1001N6-(pyridoxalphosphate)lysineImported
    Binding sitei202 – 2021N6-(pyridoxalphosphate)lysineImported
    Binding sitei207 – 2071N6-(pyridoxalphosphate)lysineImported
    Binding sitei304 – 3041N6-(pyridoxalphosphate)lysineImported

    GO - Molecular functioni

    1. L-isoleucine transaminase activity Source: UniProtKB-EC
    2. L-leucine transaminase activity Source: UniProtKB-EC
    3. L-valine transaminase activity Source: UniProtKB-EC

    GO - Biological processi

    1. branched-chain amino acid biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AminotransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Branched-chain amino acid biosynthesisUniRule annotation

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotation

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-1656-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Branched-chain-amino-acid aminotransferaseUniRule annotation (EC:2.6.1.42UniRule annotation)
    Gene namesi
    Ordered Locus Names:DR_1626Imported
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)Imported
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei202 – 2021N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi243230.DR_1626.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3UYYX-ray2.50A/B1-358[»]
    3UZBX-ray3.00A/B/C/D1-358[»]
    3UZOX-ray2.00A/B1-358[»]
    ProteinModelPortaliQ9RTX5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni238 – 2425N6-(pyridoxalphosphate)lysine bindingImported
    Regioni265 – 2673N6-(pyridoxalphosphate)lysine bindingImported

    Sequence similaritiesi

    Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000276704.
    KOiK00826.
    OMAiVKPVSVW.
    OrthoDBiEOG67MF3R.

    Family and domain databases

    InterProiIPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005786. B_amino_transII.
    [Graphical view]
    PANTHERiPTHR11825. PTHR11825. 1 hit.
    PfamiPF01063. Aminotran_4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006468. BCAT1. 1 hit.
    SUPFAMiSSF56752. SSF56752. 1 hit.
    TIGRFAMsiTIGR01123. ilvE_II. 1 hit.
    PROSITEiPS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RTX5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLTILGMTA HDSRPEQAKK LADIDWSTLG FSYIRTDLRY LAHWKDGEWD    50
    AGTLTEDNQI HLAEGSTALH YGQQCFEGLK AYRCADGSIN LFRPDQNAAR 100
    MRMSCRRLLM PELSDEQFID ACLQVVRANE HFLPPYGTGG SLYLRPFVIG 150
    VGDNIGVRTA PEFIFSVFCV PVGPYFKGGL TPTNFITSDY DRAAPHGTGA 200
    AKVGGNYAAS LLPGYEAKKR DFADVIYLDP ATHTTIEEAG AANFFAITQD 250
    GQKFVTPQSP SILPSITKYS LLWLAEHRLG LEVEEGDIRI DELGKFSEAG 300
    ACGTAAVITP IGGIQHGDDF HVFYSESEPG PVTRRLYDEL VGIQYGDKEA 350
    PEGWIVKV 358
    Length:358
    Mass (Da):39,423
    Last modified:May 1, 2000 - v1
    Checksum:i30DB1E8C80ABBA99
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11184.1.
    PIRiC75375.
    RefSeqiNP_295349.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11184; AAF11184; DR_1626.
    GeneIDi1797839.
    KEGGidra:DR_1626.
    PATRICi21630872. VBIDeiRad64572_1832.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11184.1 .
    PIRi C75375.
    RefSeqi NP_295349.1. NC_001263.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3UYY X-ray 2.50 A/B 1-358 [» ]
    3UZB X-ray 3.00 A/B/C/D 1-358 [» ]
    3UZO X-ray 2.00 A/B 1-358 [» ]
    ProteinModelPortali Q9RTX5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_1626.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11184 ; AAF11184 ; DR_1626 .
    GeneIDi 1797839.
    KEGGi dra:DR_1626.
    PATRICi 21630872. VBIDeiRad64572_1832.

    Phylogenomic databases

    HOGENOMi HOG000276704.
    KOi K00826.
    OMAi VKPVSVW.
    OrthoDBi EOG67MF3R.

    Enzyme and pathway databases

    BioCyci DRAD243230:GH46-1656-MONOMER.

    Family and domain databases

    InterProi IPR001544. Aminotrans_IV.
    IPR018300. Aminotrans_IV_CS.
    IPR005786. B_amino_transII.
    [Graphical view ]
    PANTHERi PTHR11825. PTHR11825. 1 hit.
    Pfami PF01063. Aminotran_4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006468. BCAT1. 1 hit.
    SUPFAMi SSF56752. SSF56752. 1 hit.
    TIGRFAMsi TIGR01123. ilvE_II. 1 hit.
    PROSITEi PS00770. AA_TRANSFER_CLASS_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422Imported.
    2. "Crystal structures of complexes of the branched-chain aminotransferase from Deinococcus radiodurans with ?-ketoisocaproate and L-glutamate suggest the radiation resistance of this enzyme for catalysis."
      Chen C.D., Lin C.H., Chuankhayan P., Huang Y.C., Hsieh Y.C., Huang T.F., Guan H.H., Liu M.Y., Chang W.C., Chen C.J.
      J. Bacteriol. 194:6206-6216(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH N6-(PYRIDOXALPHOSPHATE)LYSINE.

    Entry informationi

    Entry nameiQ9RTX5_DEIRA
    AccessioniPrimary (citable) accession number: Q9RTX5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 1, 2000
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3