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Q9RTS6

- TRMB_DEIRA

UniProt

Q9RTS6 - TRMB_DEIRA

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei29 – 291S-adenosyl-L-methionineUniRule annotation
    Binding sitei55 – 551S-adenosyl-L-methionineUniRule annotation
    Active sitei105 – 1051By similarity
    Binding sitei105 – 1051S-adenosyl-L-methionineUniRule annotation
    Binding sitei109 – 1091SubstrateUniRule annotation
    Binding sitei141 – 1411SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciDRAD243230:GH46-1711-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:DR_1680
    OrganismiDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
    Taxonomic identifieri243230 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000002524: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 322322tRNA (guanine-N(7)-)-methyltransferasePRO_0000171325Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243230.DR_1680.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9RTS6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000099573.
    KOiK03439.
    OMAiTKYALKW.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9RTS6-1 [UniParc]FASTAAdd to Basket

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    MIFRLGDFRF PDDPARLYPD TPDRPWVLEI GFGDGRFWPH YARTFPEPPN    50
    YLGVEISGVS LLKAHRRLKD AGLTNAVLTK LPAEVLVAQV IPHGSLDAII 100
    VNFPDPWPKA GHEDHRLLRV PFFQVAASRL KPGGAALLTT DHDEYFEFAC 150
    AQAEASGVMR VERVGPPPAA LETKYAQKWR DLGLGVNHAR FVPTRHDPVP 200
    NGTFAPYSEE DPAVPHAVLT LPADFSPQHF DKLTVRGKTW TVVLLDLYAT 250
    LRRGGWVALA HVVEGDLTQE VLVGITERED GTHLVRLAKF GGPIITPGVK 300
    AAVGAVTEWL EGQGAVVKHR GY 322
    Length:322
    Mass (Da):35,470
    Last modified:May 1, 2000 - v1
    Checksum:iB1EDAC8115BAD4A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11238.1.
    PIRiF75365.
    RefSeqiNP_295403.1. NC_001263.1.
    WP_010888315.1. NC_001263.1.

    Genome annotation databases

    EnsemblBacteriaiAAF11238; AAF11238; DR_1680.
    GeneIDi1797706.
    KEGGidra:DR_1680.
    PATRICi21630988. VBIDeiRad64572_1889.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE000513 Genomic DNA. Translation: AAF11238.1 .
    PIRi F75365.
    RefSeqi NP_295403.1. NC_001263.1.
    WP_010888315.1. NC_001263.1.

    3D structure databases

    ProteinModelPortali Q9RTS6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243230.DR_1680.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF11238 ; AAF11238 ; DR_1680 .
    GeneIDi 1797706.
    KEGGi dra:DR_1680.
    PATRICi 21630988. VBIDeiRad64572_1889.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000099573.
    KOi K03439.
    OMAi TKYALKW.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci DRAD243230:GH46-1711-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422.

    Entry informationi

    Entry nameiTRMB_DEIRA
    AccessioniPrimary (citable) accession number: Q9RTS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3