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Q9RTS6 (TRMB_DEIRA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA (guanine-N(7)-)-methyltransferase

EC=2.1.1.33
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene names
Name:trmB
Ordered Locus Names:DR_1680
OrganismDeinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422) [Reference proteome] [HAMAP]
Taxonomic identifier243230 [NCBI]
Taxonomic lineageBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity. HAMAP-Rule MF_01057

Catalytic activity

S-adenosyl-L-methionine + guanine46 in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine46 in tRNA. HAMAP-Rule MF_01057

Pathway

tRNA modification; N(7)-methylguanine-tRNA biosynthesis. HAMAP-Rule MF_01057

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.

Ontologies

Keywords
   Biological processtRNA processing
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Molecular_functiontRNA (guanine-N7-)-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322tRNA (guanine-N(7)-)-methyltransferase HAMAP-Rule MF_01057
PRO_0000171325

Sites

Active site1051 By similarity
Binding site291S-adenosyl-L-methionine By similarity
Binding site551S-adenosyl-L-methionine By similarity
Binding site1051S-adenosyl-L-methionine By similarity
Binding site1091Substrate By similarity
Binding site1411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9RTS6 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B1EDAC8115BAD4A1

FASTA32235,470
        10         20         30         40         50         60 
MIFRLGDFRF PDDPARLYPD TPDRPWVLEI GFGDGRFWPH YARTFPEPPN YLGVEISGVS 

        70         80         90        100        110        120 
LLKAHRRLKD AGLTNAVLTK LPAEVLVAQV IPHGSLDAII VNFPDPWPKA GHEDHRLLRV 

       130        140        150        160        170        180 
PFFQVAASRL KPGGAALLTT DHDEYFEFAC AQAEASGVMR VERVGPPPAA LETKYAQKWR 

       190        200        210        220        230        240 
DLGLGVNHAR FVPTRHDPVP NGTFAPYSEE DPAVPHAVLT LPADFSPQHF DKLTVRGKTW 

       250        260        270        280        290        300 
TVVLLDLYAT LRRGGWVALA HVVEGDLTQE VLVGITERED GTHLVRLAKF GGPIITPGVK 

       310        320 
AAVGAVTEWL EGQGAVVKHR GY 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE000513 Genomic DNA. Translation: AAF11238.1.
PIRF75365.
RefSeqNP_295403.1. NC_001263.1.

3D structure databases

ProteinModelPortalQ9RTS6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243230.DR_1680.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF11238; AAF11238; DR_1680.
GeneID1797706.
KEGGdra:DR_1680.
PATRIC21630988. VBIDeiRad64572_1889.

Phylogenomic databases

eggNOGCOG0220.
HOGENOMHOG000099573.
KOK03439.
OMATKYALKW.
OrthoDBEOG6K6VBC.
ProtClustDBCLSK445190.

Enzyme and pathway databases

BioCycDRAD243230:GH46-1711-MONOMER.
UniPathwayUPA00989.

Family and domain databases

HAMAPMF_01057. tRNA_methyltr_TrmB.
InterProIPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamPF02390. Methyltransf_4. 1 hit.
[Graphical view]
PROSITEPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTRMB_DEIRA
AccessionPrimary (citable) accession number: Q9RTS6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: May 1, 2000
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways